Range Anxiety
Mostrando 37-48 de 59 artigos, teses e dissertações.
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37. A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat
A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of anxiety. Despite many years of research, definitive evidence that genetic effects operate in this way is lacking. The limited behavioral test regimes so far used in
Cold Spring Harbor Laboratory Press.
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38. Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice
Estrogens are powerful modulators of neuronal physiology and in humans may affect a broad range of functions, including reproductive, emotional, and cognitive behaviors. We studied the contribution of estrogen receptors (ERs) in modulation of emotional processes and analyzed the effects of deleting ERα or ERβ in mice. Behavior consistent with increased anx
The National Academy of Sciences.
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39. Female preproenkephalin-knockout mice display altered emotional responses
The endogenous opioid system has been implicated in sexual behavior, palatable intake, fear, and anxiety. The present study examined whether ovariectomized female transgenic preproenkephalin-knockout (PPEKO) mice and their wild-type and heterozygous controls displayed alterations in fear and anxiety paradigms, sucrose intake, and lordotic behavior. To e
The National Academy of Sciences.
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40. Safe sex and women.
OBJECTIVE--Sexual behaviour, condom use, HIV knowledge and anxiety for women were examined to understand the range of sexual behaviours, predictors of safer sex and the extent of relapse. DESIGN--A cross sectional sample of women STD clinic attenders completed interviews and questionnaires. SETTING--Central London STD Clinic. SUBJECTS--153 women drawn from c
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41. Quality of life in patients with chronic obstructive pulmonary disease and severe hypoxaemia.
BACKGROUND: Patients with severe chronic obstructive pulmonary disease (COPD) have impairment in most areas of quality of life, but a relationship between impairment of the partial pressure of oxygen in arterial blood (PaO2) and quality of life has not been established. Previous studies used general health measures such as the Sickness Impact Profile (SIP).
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42. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
Exogenous neuropeptide Y (NPY) reduces experimental anxiety in a wide range of animal models. The generation of an NPY-transgenic rat has provided a unique model to examine the role of endogenous NPY in control of stress and anxiety-related behaviors using paradigms previously used by pharmacological studies. Locomotor activity and baseline behavior on
The National Academy of Sciences.
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43. Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
The molecular mechanisms that control the range and stability of emotions are unknown, yet this knowledge is critical for understanding mood disorders, especially bipolar illness. Here, we show that the glucocorticoid receptor (GR) modulates these features of emotional responsiveness. We generated transgenic mice overexpressing GR specifically in forebrain.
National Academy of Sciences.
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44. Longer term quality of life and outcome in stroke patients: is the Barthel index alone an adequate measure of outcome?
OBJECTIVES: To consider whether the Barthel Index alone provides sufficient information about the long term outcome of stroke. DESIGN: Cross sectional follow up study with a structured interview questionnaire and measures of impairment, disability, handicap, and general health. The scales used were the hospital anxiety and depression scale, mini mental state
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45. Drug misuse in a special clinic patient population in Glasgow.
During the period October, 1970, to October, 1972, a sample of 295 patients attending Special Clinics in the City of Glasgow participated in an investigation into drug misuse. Results show that, of the 136 males and 159 females who took part--all within an age range of 16 to 24 years, 43 per cent. of the males and 36 per cent. of the females admitted to havi
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46. Cori cycle activity in man
12 subjects have been studied after an overnight fast with trace amounts of pyruvate-3-14C and glucose-6-14C. Blood disappearance curves and incorporation of the pyruvate-3-14C label into blood glucose have been determined. By the use of transfer functions which allow processes with many different chemical steps to be examined as a unit, we have determined t
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47. Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates
Corticotropin-releasing factor (CRF) is a neuropeptide involved in integrating the behavioral, autonomic, and hormonal responses to stress within the central nervous system. Patients suffering from depression have abnormal activity in stress responsive brain regions and elevated cerebrospinal fluid CRF. The DSM-IV criteria for major depressive disorder inclu
National Academy of Sciences.
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48. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase
Soluble epoxide hydrolase (Ephx2, sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal phosphatase activities. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), and the phosphatase activity is suggested to be involved in cholesterol metabolism. EETs participate in a wide range of biological functio
American Physiological Society.