Raloxifene
Mostrando 1-12 de 25 artigos, teses e dissertações.
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1. LC-UV method to assay raloxifene hydrochloride in rat plasma and its application to a pharmacokinetic study
A specific, precise, and accurate LC-UV method was developed and validated to assay raloxifene hydrochloride in rat plasma. Raloxifene was analyzed after liquid-liquid extraction and quantified by reversed phase liquid chromatography (C18 column) using acetonitrile and ammonium acetate buffer 0.05 M (pH 4.0) as mobile phase at a flow rate of 1 mL.min-1 and U
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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2. A SERM increasing the expression of the osteoblastogenesis and mineralization-related proteins and improving quality of bone tissue in an experimental model of osteoporosis
Abstract Raloxifene is an antiresorptive drug, selective estrogen receptor modulator (SERM) used in the treatment of osteoporosis. Objective To evaluate proteins related to bone repair at the peri-implant bone in a rat model of osteoporosis treated with raloxifene. Material and Methods 72 rats were divided into three groups: SHAM (healthy animals), OVX (ov
J. Appl. Oral Sci.. Publicado em: 07/05/2018
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3. Development of alternative methods for the determination of raloxifene hydrochloride in tablet dosage form
Três métodos são propostos para a quantificação de cloridrato de raloxifeno em sua forma farmacêutica de comprimidos: espectrofotometria no ultravioleta (UV), cromatografia líquida de alta eficiência (HPLC) e eletroforese capilar micelar (MEKC). Estes métodos desenvolvidos e validados demonstraram linearidade, precisão e exatidão. Também foram
Braz. J. Pharm. Sci.. Publicado em: 2015-06
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4. Pharmacological management of osteogenesis
Osteogenesis and bone remodeling are complex biological processes that are essential for the formation of new bone tissue and its correct functioning. When the balance between bone resorption and formation is disrupted, bone diseases and disorders such as Paget's disease, fibrous dysplasia, osteoporosis and fragility fractures may result. Recent advances in
Clinics. Publicado em: 2014-06
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5. Enhancement of solubility and dissolution rate of poorly water soluble raloxifene using microwave induced fusion method
O objetivo do presente trabalho foi aumentar a solubilidade e taxa de dissolução do cloridrato de raloxifeno (RLX), que é pouco solúvel em água. A solubilidade do RLX aumentou com o aumento da concentração de hidroxipropilmetilcelulose (HPMC E5 LV). A proporção otimizada para a preparação de uma dispersão sólida (DS) de RLX com HPMC E5 LV utiliz
Braz. J. Pharm. Sci.. Publicado em: 2013-09
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6. Adsorptive stripping voltammetry determination of the hormone therapy Raloxifene HCl in formulation and human serum
Raloxifeno HCl (RLX) adsorveu fortemente na superfície do eletrodo de mercúrio numa monocamada com cobertura superficial de 5,724 × 10-10 mol cm-2. Dois métodos voltamétricos de redissolução catódico adsortivo com varredura linear e onda quadrada (LS-AdCSV e SW-AdCSV, respectivamente) precisos, rápidos e livres de extração são descritos para dete
J. Braz. Chem. Soc.. Publicado em: 16/08/2012
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7. Efeitos do estrogênio, raloxifeno e extrato de soja rico em genisteína sobre o osso de ratas adultas ovariectomizadas previamente androgenizadas / Effects of estrogen, raloxifene and genistein-rich soy extract on bone of ovariectomized adult female rats and previously androgenized
INTRODUCTION: Hypoestrogenism can determine bone mineral loss, resulting in decreased bone quality. To prevent that process, several drugs are administered, which can lead, however, to important side effects. Therefore, it is questionable whether the use of estrogen associated with those substances could minimize the adverse effects and maintain bone mineral
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/11/2011
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8. Expressão dos antígenos Ki-67, Bcl-2 e Bax no carcinoma de mama de mulheres tratadas com raloxifeno / Expression of Ki-67 antigen, Bcl-2 and Bax in breast carcinoma of women treated with raloxifene
Background: Breast cancer endocrinotherapy is one of the most important therapeutic strategies. Nevertheless, in spite of the positivity estrogen receptor, not always there is a good response. Therefore, there is a great interest of the researchers in finding biomarkers to evaluate the prognostic, and predict therapeutic responses. Objective: The aim of this
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/09/2009
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9. Morphological, histological and molecular effects of SERMs tamoxifen and raloxifene in primary prevention of chemically-induced mammary tumors in rats / Efeitos morfológicos, histológicos e moleculares dos moduladores seletivos dos receptores de estrogênios tamoxifeno e raloxifeno na prevenção primária de tumores mamários quimicamente induzidos em ratas
O câncer de mama é a neoplasia mais comum na população feminina, representando até um terço dos novos diagnósticos de neoplasia nessa população em algumas regiões do mundo. A prevenção primária ou secundária constitui a pedra fundamental no controle do câncer de mama; depende da identificação dos determinantes da doença, em termos de inicia
Publicado em: 2007
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10. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.
There is a medical need for an agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects on reproductive tissue. Raloxifene (LY139481 HCI) is a benzothiophene derivative that binds to the estrogen receptor and inhibits the effects of estrogen on the uterus. In an ovariectomized (OVX) rat model we inve
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11. Effects of Tamoxifen and Raloxifene on Memory and Other Cognitive Abilities: Cognition in the Study of Tamoxifen and Raloxifene
American Society of Clinical Oncology.
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12. Molecular determinants of tissue selectivity in estrogen receptor modulators
Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand complex have been postulated to influence unique subsets of estrogen-responsive genes resulting in differential modulation and, ultimately, tissue-selective outcomes. The estr
The National Academy of Sciences of the USA.