R1 And D3 Cell Lines
Mostrando 13-24 de 116 artigos, teses e dissertações.
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13. Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus
Pterodon emarginatus Vogel, Fabaceae, is a native aromatic tree distributed by central region of Brazil. Hydroalcoholic infusions of the seeds are used in folk medicine for their anti-rheumatic and anti-inflammatory properties. The objective of this work was identified the chemical components and verify the cytotoxic effect of the essential oil (EO) from P.
Rev. bras. farmacogn.. Publicado em: 03/04/2012
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14. Efeito de hipolipemiantes sobre a expressão de genes envolvidos no transporte reverso do colesterol / Statin effects on expression of genes involved in reverse cholesterol transport
The efficacy of statins in reducing the risk of coronary events is not completely explained by their effects in decreasing cholesterol low-density lipoprotein (LDL-C). One of their additional effects may result from the change in concentration of high-density lipoprotein (HDL), recognized as atheroprotective, mainly for the role in reverse cholesterol transp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/09/2011
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15. Inhibition of cytohesin-1 by siRNA leads to reduced IGFR signaling in prostate cancer
To explore how cytohesin-1 (CYTH-1) small interfering RNA (siRNA) influences the insulin-like growth factor receptor (IGFR)-associated signal transduction in prostate cancer, we transfected human prostate cancer PC-3 cell lines with liposome-encapsulatedCYTH-1 siRNA in serum-free medium and exposed the cells to 100 nM IGF-1. The mRNA and protein levels of th
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-07
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16. Mouse embryonic stem cells: the establishment of the system to produce differentiated cell types in vitro
During the last few years, embryonic stem (ES) cells have been a new tool in cell biology which is very promising for the scientific community to develop new cell therapies. ES cells are the only cell type that can differentiate into derivates of the three primary germ layers, not only in vivo but also, and most important, in vitro. This so-called pluripoten
Publicado em: 2010
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17. Molecular determinants of response and resistance to tyrosine kinase inhibitors (TKIs in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) gene mutation / Determinantes moleculares de resposta e resistencia aos inibidores da tirosina quinase (TKI) em pacientes com carcinoma de pulmão não pequenas celulas (CPNPC) com mutações no gene do recptor do fator de crescimento epidermico (EGFR)
Most advanced non-small cell lung cancers (NSCLCs) with activating epidermal growth factor receptor (EGFR) mutations (exon 19 deletions or L858R) initially respond to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib. However, over time (median of 6-12 months) most tumors develop acquired resistance to EGFR TKIs. Intense research in these NS
Publicado em: 2008
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18. Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy
The anti-tumor effect of the Moroccan endemic thyme (Thymus broussonettii) essential oil (EOT) was investigated in vitro using the human ovarian adenocarcinoma IGR-OV1 parental cell line OV1/P and its chemoresistant counterparts OV1/adriamycin (OV1/ADR), OV1/vincristine (OV1/VCR), and OV1/cisplatin (OV1/CDDP). All of these cell lines elicited various degrees
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-11
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19. Química e atividades biológicas de Hancornia speciosa Gomes (Apocynaceae):: inibição da enzima conversora de angiotensina (ECA) e efeito na quimioprevenção de câncer
Hancornia speciosa Gomes (Apocynaceae) is a plant species found in cerrado, a savannahlike vegetation, popularly used to treat hypertension and inflammatory processes. Its potential anti-hypertensive activity has been previously demonstrated by in vitro inhibition of angiotensin converting enzyme (ACE) and vasodilatation in rat aortic rings. Several studies
Publicado em: 2007
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20. In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper
Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper. Both have been reported to show cytotoxic activity towards several tumor cell lines. In the present study, the in vivo antitumor activity of these compoun
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-06
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21. Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro
Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. Then, can it repress the cancer cells' metastasis potential? To elucidate this issue, the present st
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-05
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22. Differential regulation of vitamin D receptor expression in distinct leukemic cell lines upon phorbol ester-induced growth arrest
A close correlation between vitamin D receptor (VDR) abundance and cell proliferation rate has been shown in NIH-3T3 fibroblasts, MCF-7 breast cancer and in HL-60 myeloblastic cells. We have now determined if this association occurs in other leukemic cell lines, U937 and K562, and if VDR content is related to c-myc expression, which is also linked to cell gr
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-05
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23. Human cell lines expressing intestinal alkaline phosphatase.
At least three loci determine human alkaline phosphatases [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1]: one coding for the placental form of the enzyme, at least one coding for the intestinal forms, and at least one for the liver, bone, and kidney forms. The alkaline phosphatase in cell line D98/AH-2 has been characterized by i
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24. Macrophage cell lines P388D1 and IC-21 stimulated with gamma interferon fail to inhibit the intracellular growth of Histoplasma capsulatum.
Histoplasma capsulatum, a facultative intracellular parasite of macrophages, grows within mononuclear cells of the P388D1 and IC-21 cell lines with a generation time comparable to that with which it grows in normal resident peritoneal macrophages (10 +/- 2 h). Recombinant murine gamma interferon (rMuIFN-gamma) activates P388D1 cells to express la antigens bu