Mostrando 1-12 de 19 artigos, teses e dissertações.
1. Papel do sistema histaminérgico nos processos de aprendizagem e memória em Carassius auratus após ablação cerebelar
This study investigated the effect of post-training treatment with L-histidine, Pyrilamine and Zolantidine on the memory consolidation of inhibitory avoidance in Carassius auratus submitted to cerebellar ablation. Cerebellar ablation was performed 3 days before the experiment. The inhibitory avoidance procedure included one habituation day, one training day
Publicado em: 2009
2. Desenvolvimento de um modelo comportamental de dor na ATM de ratos : participação dos receptores H1
The TMJ pain conditions are poorly understood. Considering that the subcutaneous formalin injection has been widely used as an experimental model for studying pain mechanisms, the aim of this study was to characterize the nociceptive behavioral responses induced by the formalin injection into the TMJ region of rats and verify the role of the peripheral Hl hi
Publicado em: 1999
3. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs.
Skin mast cells release the neutral protease chymase along with histamine during degranulation. To test the hypothesis that chymase modulates histamine-induced plasma extravasation, we measured wheal formation following intradermal injection of purified mast cell chymase and histamine into the skin of ragweed-allergic dogs. We found that chymase greatly augm
4. Histamine H1 receptor activation blocks two classes of potassium current, IK(rest) and IAHP, to excite ferret vagal afferents.
1. Intracellular recordings were made in intact and acutely dissociated vagal afferent neurones (nodose ganglion cells) of the ferret to investigate the membrane effects of histamine. 2. In current-clamp or voltage-clamp recordings, histamine (10 microM) depolarized the membrane potential (10 +/- 0.8 mV; mean +/- S.E.M.; n = 27) or produced an inward current
5. Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors
From pharmacological studies using histamine antagonists and agonists, it has been demonstrated that histamine modulates many physiological functions of the hypothalamus, such as arousal state, locomotor activity, feeding, and drinking. Three kinds of receptors (H1, H2, and H3) mediate these actions. To define the contribution of the histamine H1 recep
The National Academy of Sciences of the USA.
6. Effect of histamine on proliferation of normal human adult lung fibroblasts.
Fibrotic lung tissue shows increased connective tissue deposition and fibroblast proliferation and in addition a substantial increase in mast cell numbers in and around the fibrotic area. To elucidate the question of whether products of mast cells affect the proliferative behaviour of structural cells in the lung and thereby contribute to fibrogenesis, the e
7. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
Analysis of mRNA from multiple sclerosis lesions revealed increased amounts of transcripts for several genes encoding molecules traditionally associated with allergic responses, including prostaglandin D synthase, histamine receptor type 1 (H1R), platelet activating factor receptor, Ig Fc ɛ receptor 1 (FcɛRI), and tryptase. We now demonstrate that, in the
The National Academy of Sciences.
8. Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine.
The actions of histamine on myenteric neurones were investigated with intracellular recording methods in guinea-pig small intestine. The actions of histamine at the ganglion cell soma were: membrane depolarization, increased input resistance, suppression of post-spike hyperpolarizing potentials, augmented excitability and repetitive spike discharge. Excitabi
9. Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 fluoroquinolones and effects of anti-inflammatory compounds.
Fluoroquinolone antibacterial agents have been reported to induce tendon lesions in juvenile rats. In the present study, we characterized fluoroquinolone-induced Achilles tendon lesions by comparing the effects of 10 fluoroquinolones and examining the potential of one of these antimicrobial agents, pefloxacin, to induce tendon lesions when coadministered wit
10. Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1.
A method for measuring fluorescence in anchored monolayers of human endothelial cells is described and used to demonstrate changes in the cytosolic free-calcium concentration ([Ca2+]c) in these cells exposed to histamine and thrombin; some endothelial responses to both agonists (e.g., mitogenesis) have been suggested to be Ca2+-mediated. Umbilical vein endot
11. Neurokinin A increases short-circuit current across rat colonic mucosa: a role for vasoactive intestinal polypeptide.
1. Neurokinin A (NKA) is a mammalian tachykinin distributed principally in the nervous system, including the myenteric innervation of the gut. 2. NKA may be involved in neurogenic inflammation and as a modulatory factor in the diarrhoea associated with mucosal inflammation of inflammatory bowel disease (ulcerative colitis). 3. We evaluated the effect of NKA
12. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.
Acute ultraviolet light B (UVB) injury is associated with dermal mast cell histamine release. The possibility that histamine-stimulated prostaglandin (PG) synthesis could be a mechanism for irradiation erythema was therefore examined using human skin explants. Explants responded to UV irradiation (120 mJ/cm2) with a fivefold increase in synthesis of prostagl