Pyridoxal Phosphate
Mostrando 1-12 de 265 artigos, teses e dissertações.
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1. A two-year follow-up of asfotase alfa replacement in a patient with hypophosphatasia: clinical, biochemical, and radiological evaluation
SUMMARY Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benef
Arch. Endocrinol. Metab.. Publicado em: 2020-10
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2. Treatment of insomnia with repetitive transcranial magnetic stimulation (rTMS) in a patient with posttraumatic stress disorder (PTSD)
SUMMARY Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benef
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2020-10
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3. Micronutrients: Speculation on Inborn Errors, Nutrigenomics, Evolution, the Microbiome, and Nutritional Immunity
Abstract Many micronutrients or cofactors derived from micronutrients are highly reactive, hence their role in catalysis of reactions by enzymes. The concentration of cofactors has to be kept low to avoid unwanted reactions while allowing them to bind to the (apo)enzymes that need them. A new disorder causing B6-responsive epilepsy (proline synthetase cotran
J. inborn errors metab. screen.. Publicado em: 28/02/2019
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4. Submerged fermentation of Lactobacillus rhamnosus YS9 for γ-aminobutyric acid (GABA) production
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in central nervous system, and its application in drugs and functional foods has attracted great attention. To enhance production of y-aminobutyric acid, Lactobacillus rhamnosus YS9, a strain isolated from Chinese traditional fermented food pickled vegetable, was grown under submerged ferment
Braz. J. Microbiol.. Publicado em: 2013
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5. Comparação entre as dosagens de ast (aspartato aminotransferase) e alt (alanina aminotransferase) em presença e na ausência de piridoxal fosfato
As aminotransferases catalisam a transferência de um grupo alfa-amino de um aminoácido para um alfa-cetoácido, com a formação de novos alfa- amino e alfacetoácido. O piridoxal fosfato é o co-fator biológico utilizado pelas transaminases e sua utilização, durante o doseamento dessas enzimas, é recomendada pelo IFCC (International Federation of Clin
Publicado em: 2010
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6. Novas abordagens a promoção das pequenas empresas
Muitos estudos evidenciam o papel do ATP no processo de desencadeamento da dor por agir em receptores P2X expressos nos terminais nervosos aferentes nociceptivos. Para investigar se esses receptores exercem uma função na dor da ATM, estudamos a presença de receptores P2X funcionais na ATM de ratos, examinando as conseqüências comportamentais da administ
Publicado em: 2003
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7. Avaliação da presença de receptores purinergicos P2X funcionais na região da ATM de ratos e do papel do ATP endogeno na sensibilização dos nociceptores da ATM
Muitos estudos evidenciam o papel do ATP no processo de desencadeamento da dor por agir em receptores P2X expressos nos terminais nervosos aferentes nociceptivos. Para investigar se esses receptores exercem uma função na dor da ATM, estudamos a presença de receptores P2X funcionais na ATM de ratos, examinando as conseqüências comportamentais da administ
Publicado em: 2003
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8. Pyridoxal phosphate as an antisickling agent in vitro.
Although pyridoxal phosphate is known to inhibit gelation of purified hemoglobin S, antisickling activity has never been demonstrated for intact erythrocytes. We incubated washed erythrocytes at 37 degrees C either in buffer alone, or with added pyridoxal phosphate or pyridoxal, washed these cells, suspended them in untreated buffer, and compared the percent
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9. A fluorimetric method for the measurement of pyridoxal and pyridoxal phosphate in human plasma and leucocytes, and its application to patients with sideroblastic marrows.
A highly sensitive fluorimetric assay for the measurement of pyridoxal and pyridoxal phosphate in biological tissues is described. The method involves the enzymic hydrolysis of pyridoxal phosphate to pyridoxal. The pyridoxal (free or total) is separated on an anion-exchange column, concentrated by cation-exchange chromatography and reacted with potassium cya
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10. Pyridine analogs inhibit the glucosyltransferase of Streptococcus mutans.
Soluble glucan synthesis catalyzed by dextransucrase preparations from Streptococcus mutans 6715 were inhibited by pyridoxal-5-phosphate and several other pyridine analogs, including pyridoxine, pyridoxamine, pyridoxamine-5-phosphate, pyridoxal, and 4-pyridoxic acid. Pyridine and pyridine-4-carboxaldehyde were not effective inhibitors of the enzyme. Kinetic
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11. Affinity of Cystathionine β-Synthase for Pyridoxal 5′-Phosphate in Cultured Cells: A MECHANISM FOR PYRIDOXINE-RESPONSIVE HOMOCYSTINURIA
Previous attempts to correlate in vivo pyridoxine-responsiveness with in vitro assays of cystathionine β-synthase activity in synthase-deficient homocystinuric patients have been only partially successful. All such studies, however, have been conducted with extracts of cultured skin fibroblasts grown in medium containing a high concentration (1,000 ng/ml) o
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12. Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism.
Individuals with chronic alcohol abuse frequently exhibit lowered plasma levels of pyridoxal 5'-phosphate, the coenzyme form of vitamin B6. Because the liver is the primary source of this coenzyme in plasma and also the principal organ that oxidizes ethanol, the effect of ethanol on hepatic pyridoxal phosphate metabolism was studied in the rat. The chronic f