Pyridostigmine
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Acute electrophysiologic consequences of pyridostigmine inhibition of cholinesterase in humans
The cardiovascular electrophysiologic basis for the action of pyridostigmine, an acetylcholinesterase inhibitor, has not been investigated. The objective of the present study was to determine the cardiac electrophysiologic effects of a single dose of pyridostigmine bromide in an open-label, quasi-experimental protocol. Fifteen patients who had been indicated
Publicado em: 2011
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2. Avaliação do efeito da administração de piridostigmina sobre a variabilidade da frequência cardíaca em pacientes portadores de diabetes mellitus tipo 2 com neuropatia autonômica cardiovascular
Objetivos/Hipótese: A Piridostigmina bloqueia a acetilcolinesterase, promove estimulação colinérgica e aumenta a variabilidade da freqüência cardíaca (VFC) em indivíduos saudáveis e com insuficiência cardíaca. Os efeitos sobre a modulação autonômica no diabetes mellitus tipo 2 (DM2) são desconhecidos. Nós testamos a hipótese de que a adminis
Publicado em: 2011
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3. Acute electrophysiologic consequences of pyridostigmine inhibition of cholinesterase in humans
The cardiovascular electrophysiologic basis for the action of pyridostigmine, an acetylcholinesterase inhibitor, has not been investigated. The objective of the present study was to determine the cardiac electrophysiologic effects of a single dose of pyridostigmine bromide in an open-label, quasi-experimental protocol. Fifteen patients who had been indicated
Brazilian Journal of Medical and Biological Research. Publicado em: 15/01/2010
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4. Avaliação da atividade cardioprotetora da piridostigmina veiculada em lipossomas
The demonstration of the benefits of vagal stimulation in patients with cardiovascular diseases suggests that cholinergic drugs may have similar protective effects. Pyridostigmine, a reversible anticholinesterase agent, has benefits demonstrated in patients with cardiac failure. However, its short half-life of elimination and the incidence of adverse effects
Publicado em: 2009
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5. Impacto da preservação parassimpática sobre os aspectos morfofuncionais cardíacos em ratos infartados / Parassympathic preservation impact in cardiac morphofunctional aspects in myocardial infarcted rats
Neste estudo, testamos a hipótese de que a estimulação colnérgica pela administração de piridostigmina, um agente anticolinesterásico reversível, protege o miocárdio submetido à isquemia miocárdica crônica durante 3 tempos de observação: 7, 21 e 42 dias. Para essa avaliação foram medidos a área de acinesia (índicador de área de infarto), o
Publicado em: 2009
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6. Cholinergic stimulation with pyridostigmine reduces the QTc interval in coronary artery disease
Parasympathetic dysfunction is an independent risk factor in patients with coronary artery disease; thus, cholinergic stimulation is a potential therapeutic measure that may be protective by acting on ventricular repolarization. The purpose of the present study was to determine the effects of pyridostigmine bromide (PYR), a reversible anticholinesterase agen
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-06
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7. Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for ada
Arquivos Brasileiros de Cardiologia. Publicado em: 2001-04
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8. Reduction of QTc interval dispersion. Potential mechanism of cardiac protection of pyridostigmine bromide
OBJECTIVE: Parasympathetic dysfunction is an independent risk factor in individuals with coronary artery disease, and cholinergic stimulation is a potential therapeutical option. We determined the effects of pyridostigmine bromide, a reversible anticholinesterase agent, on electrocardiographic variables of healthy individuals. METHODS: We carried out a cross
Arquivos Brasileiros de Cardiologia. Publicado em: 2000-09
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9. Sintese de R.M.N. de carbono-13 de haletos de 1,1 dimetil-2,6-diidro-3-ceto-piridinios-5-substituidos
The aim this work has been the synthesis and C n.m.r. studies of N-Acetony-N,N-dimethylglicine halides and 1,1-dimethyl-2,6-dihidro-3-keto-piridinium halides with substituents in the carbon-5. These new compounds are intermediates in the synthesis of pyridostigmine, a anti- cholinesterasic agent, that our group wants to synthesize. Most of compounds was synt
Publicado em: 1995
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10. Neuromuscular function and plasma drug levels in pyridostigmine treatment of myasthenia gravis.
In 18 patients with generalised myasthenia treated with oral pyridostigmine, muscular strength, decrement of neuromuscular transmission in the trapezius muscle on repetitive accessory nerve stimulation, and pyridostigmine plasma level were measured repeatedly during 1-3 dosing intervals. Significant correlations between pyridostigmine concentrations and func
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11. Clinical pharmacology of pyridostigmine and neostigmine in patients with myasthenia gravis.
Determination of plasma concentration of pyridostigmine in 20 myasthenic patients on maintenance therapy revealed rather small intraindividual variations within a dose interval. The predose concentration varied considerably between different patients and up to seven fold in patients on the same daily dose. No pharmacokinetic interaction between pyridostigmin
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12. Comparative effects of plasma exchange and pyridostigmine on respiratory muscle strength and breathing pattern in patients with myasthenia gravis.
BACKGROUND--Pyridostigmine, an acetylcholinesterase antagonist, is useful in improving respiratory function in patients with myasthenia gravis. More recently, plasma exchange has been employed in myasthenia gravis because it acts presumably by removal of circulating antibodies against acetylcholine receptors. Surprisingly, comparative data on the effects of