Pyridinones
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Síntese e atividade biológica de pironas e piridinonas derivadas do ácido desidroacético / Synthesis and biological activities of pyrones and pyridinones derived from dehydroacetic acid
Um grande número de compostos contendo o anel piran-2-ona ou piridin-2-ona apresenta atividade antibacteriana, antifúngica, antimalárica, cardiotônica, analgésica, anti-inflamatória, citotóxica, neurotóxica, inseticida, anti-HIV, antioxidante e fitotóxica. O presente trabalho teve como objetivos sintetizar enaminopiranonas contendo o anel piran-2-on
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2010
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2. Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.
Derivatives of pyridinones were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity and prevent the spread of HIV-1 infection in cell culture without an appreciable effect on other retroviral or cellular polymerases. 3-[( (4,7-Dimethyl-1,3-benzoxazol-2-yl) methyl]amino ]-5-ethyl-6-methylpyridin-2(1H)-one (L-697,63
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3. Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.
The nonnucleoside reverse transcriptase (RT) inhibitors comprise a class of structurally diverse compounds that are functionally related and specific for the human immunodeficiency virus type 1 RT. Viral variants resistant to these compounds arise readily in cell culture and in treated, infected human. Therefore, the eventual clinical usefulness of the nonnu
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4. A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors.
Pyridinone derivatives are potent and specific inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and HIV-1 replication in cell culture. However, the potential clinical usefulness of these compounds as monotherapeutic agents may be limited by the selection of inhibitor-resistant viral variants. Resistance in cell culture is