Purifying Selection
Mostrando 1-12 de 77 artigos, teses e dissertações.
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1. Comparative genome analysis of the SPL gene family reveals novel evolutionary features in maize
Abstract SPLs are plant-specific transcription factors that play important regulatory roles in plant growth and development. Systematic analysis of the SPL family has been performed in numerous plants, such as Arabidopsis, rice, and Populus. However, no comparative analysis has been performed across different species to examine evolutionary features. In this
Genet. Mol. Biol.. Publicado em: 01/07/2019
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2. Evolution of DNMT2 in drosophilids: Evidence for positive and purifying selection and insights into new protein (pathways) interactions
Abstract The DNA methyltransferase 2 (DNMT2) protein is the most conserved member of the DNA methyltransferase family. Nevertheless, its substrate specificity is still controversial and elusive. The genomic role and determinants of DNA methylation are poorly understood in invertebrates, and several mechanisms and associations are suggested. In Drosophila, th
Genet. Mol. Biol.. Publicado em: 26/03/2018
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3. Characterization and expression of the ABC family (G group) in ‘Dangshansuli’ pear (Pyrus bretschneideri Rehd.) and its russet mutant
Abstract The plant genes encoding ABCGs that have been identified to date play a role in suberin formation in response to abiotic and biotic stress. In the present study, 80 ABCG genes were identified in ‘Dangshansuli’ Chinese white pear and designated as PbABCGs. Based on the structural characteristics and phylogenetic analysis, the PbABCG family genes
Genet. Mol. Biol.. Publicado em: 2018-03
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4. Identification of circo-like virus-Brazil genomic sequences in raw sewage from the metropolitan area of São Paulo: evidence of circulation two and three years after the first detection
BACKGROUND Two novel viruses named circo-like virus-Brazil (CLV-BR) hs1 and hs2 were previously discovered in a Brazilian human fecal sample through metagenomics. CLV-BR hs1 and hs2 possess a small circular DNA genome encoding a replication initiator protein (Rep), and the two genomes exhibit 92% nucleotide identity with each other. Phylogenetic analysis b
Mem. Inst. Oswaldo Cruz. Publicado em: 30/01/2017
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5. Genetic structure of a Brazilian population of the begomovirus Tomato severe rugose virus (ToSRV)
Begomoviruses are whitefly-transmitted single-stranded DNA viruses of great economic importance in the tropics and subtropics. Several begomovirus species have been reported in tomatoes in Brazil, but only a few predominate in the field, for unknown reasons. In this study begomovirus-infected tomato samples were collected in Viçosa, State of Minas Gerais, i
Trop. plant pathol.. Publicado em: 2012-10
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6. Uma abordagem estocástica da evolução do sexo e recombinação / Uma abordagem estocástica da evolução do sexo e recombinação
The understanding of the central mechanisms favouring sex and recombination in real populations is one of the fundamental issues in evolutionary biology. Based on a previous stochastic formulation to the study of sex, here we aim to investigate the conditions under which epistasis favours the fixation of the sexual mode of reproduction in a given population.
Publicado em: 2009
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7. Aspectos moleculares da evolução do gene DARC em primatas / Molecular aspects of DARC gene evolution in primates
Genes involved in pathogen-host interactions are strongly affected by positive natural selection. The gene of blood Duffy antigen, also known as DARC (Duffy Antigen Receptor for Chemokines), has an important role in the invasion of red blood cells by the parasites that cause malaria, Plasmodium vivax in humans and Plasmodium knowlesi in other primates. The s
Publicado em: 2008
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8. Mapping and regulatory mechanisms study of genes associated with caraniofacial malformations / "Estudo de mecanismos regulatórios e mapeamento de genes associados a malformações craniofaciais"
In the present study, we investigate two craniofacial mendelian disorders, resulting from abnormalities in the development of the first and second pharyngeal arches: the Treacher Collins Syndrome (TCS ) and the auriculo condylar syndrome (ACS). The identification of genes and molecular mechanisms associated to these conditions, in addition to contributing to
Publicado em: 2007
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9. Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)
In the present study, the coding region of the H gene was sequenced and analyzed in fourteen genera of New World primates (Alouatta, Aotus, Ateles, Brachyteles, Cacajao, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri), in order to investigate the evolution of the gene. The analyses revealed that this cod
Genetics and Molecular Biology. Publicado em: 2004
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10. Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3
Amino acid replacements encoded by the prion protein gene (PRNP) have been associated with transmissible and hereditary spongiform encephalopathies in mammalian species. However, an association between bovine spongiform encephalopathy (BSE) and bovine PRNP exon 3 has not been detected. Moreover, little is currently known regarding the mechanisms of evolution
National Academy of Sciences.
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11. Widespread purifying selection at polymorphic sites in human protein-coding loci
Estimation of gene diversity (heterozygosity) at 1,442 single-nucleotide polymorphism (SNP) loci in an ethnically diverse sample of humans revealed consistently reduced gene diversities at SNP loci causing amino acid changes, particularly those causing amino acid changes predicted to be disruptive to protein structure. The reduction of gene diversity at thes
National Academy of Sciences.
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12. Selection on the Genes of Euplotes crassus Tec1 and Tec2 Transposons: Evolutionary Appearance of a Programmed Frameshift in a Tec2 Gene Encoding a Tyrosine Family Site-Specific Recombinase
The Tec1 and Tec2 transposons of the ciliate Euplotes crassus carry a gene for a tyrosine-type site-specific recombinase. The expression of the Tec2 gene apparently uses a programmed +1 frameshift. To test this hypothesis, we first examined whether this gene has evolved under purifying selection in Tec1 and Tec2. Each element carries three genes, and each ha
American Society for Microbiology.