Pulmonary Emphysema Animal
Mostrando 1-10 de 10 artigos, teses e dissertações.
-
1. Terapêutica experimental com células mononucleares da medula óssea em modelo animal de enfisema pulmonar. / Experimental therapy with bone marrow mononuclear cells in animal model of pulmonary emphysema.
O enfisema pulmonar define-se como a destruição das paredes alveolares e consequente dispneia progressiva. Este trabalho objetivou a adequação de um modelo de transplante celular in vivo de BMMC em camundongos com enfisema pulmonar. O enfisema foi induzido por instilação nasal de elastase (4 UI por animal). O diâmetro alveolar médio para os grupos n�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/10/2011
-
2. Análise temporal de mecânica respiratória e morfometria pulmonar em camundongos após instilação nasal de papaína / Temporal analysis of respiratory mechanics and lung morphometry in mice after nasal instillation of papain
Objetivos: Verificar alterações na mecânica e parâmetros de morfometria pulmonar em um estudo temporal sobre enfisema em um modelo animal. Métodos:Setenta camundongos Balb / c receberam instilação nasal de solução de papaína ou salina e foram estudados no 1º, 3º, 15º, 28º e 40º dias após a instilação. Resistência das vias aéreas (Raw), Re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/05/2011
-
3. "Avaliação das alterações anatômicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos" / Evaluation of the cardiac anatomical alterations secondary to the pulmonary emphysema : experimental study in rats
Analisamos as alterações cardíacas pós-indução de enfisema por instilação de papaína. Foram avaliados 75 ratos (grupos papaína e controle), sacrificados 30, 60, 90, 120 ou 180 dias pós-instilação. Foram realizados: gasometria do sangue arterial, avaliação morfométrica cardíaca e pulmonar. A papaína produziu destruição alveolar compatível
Publicado em: 2004
-
4. Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion
Emphysema is a pulmonary disease characterized by alveolar wall destruction, resulting in enlargement of gas exchange spaces without fibrosis. This condition is a part of chronic obstructive pulmonary disease (COPD), which causes 3.5% of deaths worldwide [Anonymous (1990) World Health Stat. Q. Special, 1–51] and contributes greatly to the global burde
The National Academy of Sciences.
-
5. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity
Emphysema and bronchitis are major components of chronic obstructive pulmonary disease (COPD). Pleomorphic adenoma gene like-2 (PLAGL2), a zinc finger DNA-binding protein, is a transcription factor of the surfactant protein C (SP-C) promoter. Using an inducible transgenic mouse model, PLAGL2 and SP-C were ectopically expressed in lung epithelial cells of ter
American Physiological Society.
-
6. A model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T.
The objective of this study was to develop an animal model representative of chronic human alpha-1-proteinase inhibitor deficiency. Eight dogs were treated with a mild oxidizing agent, chloramine T, with varying regimens for 3--27 wk. The capacity of the serum to inhibit both trypsin and elastase was examined and found to respond differently. Although immuno
-
7. Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route
Although heparin and low-molecular-weight heparins (LMWH) have been widely used clinically as anticoagulants, their broader use has been limited by the lack of noninvasive delivery methods for this class of molecules. In this study, we demonstrate an efficient, rapid, and reproducible delivery system for heparin through the lungs that is not confined to part
National Academy of Sciences.
-
8. Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?
The diaphragm and other respiratory muscles undergo extensive remodeling in both animal models of emphysema and in human chronic obstructive pulmonary disease, but the nature of the remodeling is different in many respects. One common feature is a shift toward improved endurance characteristics and increased oxidative capacity. Furthermore, both animals and
American Physiological Society.
-
9. Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo.
A common feature of cigarette-smoke (CS)-associated diseases such as atherosclerosis and pulmonary emphysema is the activation, aggregation, and adhesion of leukocytes to micro- and macrovascular endothelium. A previous study, using a skinfold chamber model for intravital fluorescence microscopy in awake hamsters, has shown that exposure of hamsters to the s
-
10. Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice.
Circulating alpha 1-antitrypsin is synthesized primarily in the liver and secreted into the bloodstream, where it serves as the major protease inhibitor. The PiZ variant of alpha 1-antitrypsin is associated with decreased levels of the protein in sera as a result of its retention within hepatocytes. Homozygosity for the variant allele predisposes individuals