Proteome Toxicity
Mostrando 1-5 de 5 artigos, teses e dissertações.
-
1. Análise proteômica em urina e rim de ratos submetidos a tratamento crônico com flúor / Proteomic analysis of urine kidney in fluoride-treated rat
Two-dimensional gel electrophoresis (2D-PAGE) based proteomics approach was used to better understand the molecular mechanisms of renal injury induced by fluoride (F) and define potentials biomarkers of fluorosis. Three groups of weanling male Wistar rats (21 days old) were treated with drinking water containing 0 (control), 5, or 50 ppm F for 60 days (n=6/g
Publicado em: 2008
-
2. Identification of proteins from honeybee venom (Apis mellifera L.) immunoreactives to antivenom serum through a proteomic approach / Identificação das proteínas do veneno de abelhas africanizadas (Apis mellifera L.) imunoreativas ao soro antiveneno por abordagem proteômica
O estudo de venenos de artrópodes é de grande interesse para melhorar os tratamentos contra envenenamentos e oferece uma ótima ferramenta para melhor compreensão dos sistemas nervoso e imunológico, coagulação sanguínea e respostas inflamatórias. As abelhas são um dos animais venenosos mais estudados e a elucidação do seu proteoma é de interesse
Publicado em: 2008
-
3. Effect of Manganese Toxicity on the Proteome of the Leaf Apoplast in Cowpea1
Excess manganese (Mn) supply causes formation of visible brown depositions in the cell walls of leaves of cowpea (Vigna unguiculata), which consist of oxidized Mn and oxidized phenols. Because oxidation of Mn and phenolic compounds in the leaf apoplast was proposed to be catalyzed by apoplastic peroxidases (PODs), induction of these enzymes by Mn excess was
The American Society for Plant Biologists.
-
4. Changes in the Spinal Cord Proteome of an Amyotrophic Lateral Sclerosis Murine Model Determined by Differential In-gel Electrophoresis *S⃞
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by loss of motor neurons resulting in progressive paralysis. To date, more than 140 different mutations in the gene encoding CuZn-superoxide dismutase (SOD1) have been associated with ALS. Several transgenic murine models exist in which various mutant SOD1s are expressed.
American Society for Biochemistry and Molecular Biology.
-
5. SELDI ProteinChip® Array Technology: Protein-Based Predictive Medicine and Drug Discovery Applications
Predictive medicine, utilizing the ProteinChip® Array technology, will develop through the implementation of novel biomarkers and multimarker patterns for detecting disease, determining patient prognosis, monitoring drug effects such as efficacy or toxicity, and for defining treatment options. These biomarkers may also serve as novel protein drug candidates
Hindawi Publishing Corporation.