Protein C Erbb 2
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Expression of merlin, NDRG2, ERBB2, and c-MYC in meningiomas: relationship with tumor grade and recurrence
Meningiomas are common, usually benign tumors of the central nervous system that have a high rate of post-surgical recurrence or regrowth. We determined expression of the proteins merlin, NDRG2, ERBB2, and c-MYC in meningiomas using immunohistochemistry and assessed relationships between protein expression and gender, age, tumor grade, and recurrence or regr
Braz J Med Biol Res. Publicado em: 18/03/2016
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2. Expressão imunoistoquímica das proteínas c-erbB-2 e vimentina em carcinomas epidermóides bucais em correlação com características clínicas e prognóstico / Protein expression by immunohistochemistry of c-erbB-2 and vimentin in oral squamous cell carcinoma correlated with clinical features and prognosis
About of malignancies in oral mucosa, 95% are represented by oral squamous cell carcinoma (OSCC). This disease is usually aggressive, with unpredictable biological behavior and poor prognosis and the local infiltration and consequent metastases the main cause of death of patients. The identification of molecular markers that may predict the clinical course o
Publicado em: 2009
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3. Expressão da acido graxo sintase, ErbB-2, p27 E Skp2 na carinogenese bucal induzida por 1-oxido 4-nitroquinolina em camundongos e efeito antitumoral do Orlistat / Fatty Acid Sintase, ErbB-2, p27 E Skp2 expression in oral carcinogenesis induced by 4-nitroquinoline 1-oxide and antitumoral Orlistat effects
Squamous cell carcinoma of the oral cavity is one of the most common malignant epithelial neoplasms, and a better understanding of its molecular pathways could help the development of new treatment or preventive agents. Several proteins such as Fatty Acid Synthase (FAS), ErbB-2, p27 and Skp2 are involved in the tumorigenesis process. FAS has an enzyme with m
Publicado em: 2007
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4. Gene amplification in carcinogenesis
Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to play a major role during embryonic development due to the fact that they are responsible for the programmed
Genetics and Molecular Biology. Publicado em: 2006
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5. Immunohistochemistry analysis of osteosarcoma in patients with and without metastasis and its prognosis correlation / "Análise imunohistoquímica do osteossarcoma em pacientes com e sem metástases e sua correlação prognóstica"
We study, by imunohistochemistry technique, the proteins p53, MDM-2, c-Kit, ErbB-2, PCNA and p-glycoprotein in samples of osteosarcoma tumors at diagnosis and its correlation with the prognosis of this patients. The p-53 was positive in 23,1% (9/39), PCNA in 71,4% (25/35), p-glycoprotein in 40,5% (15/37), MDM-2 in 34,8% (8/23), c-kit in 67,8%(25/37) and ErbB
Publicado em: 2005
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6. 17 beta-estradiol mimics ligand activity of the c-erbB2 protooncogene product.
We report here the physical and functional interaction of estrogen with the ErbB2 protein p185c-erbB2. The ErbB2 protein immunoprecipitated from estrogen-treated [10(-8) to 10(-6) M 17 beta-estradiol (E2)] RC cells showed higher autophosphorylation activity than that from untreated cells. Likewise autophosphorylation activity of ErbB2 protein from untreated
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7. Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.
The epidermal growth factor receptor (EGF-R) and the erbB-2 proto-oncogene product protein are closely related by their structural homology and their shared enzymatic activity as autophosphorylating tyrosine kinases. We show that in mammary tumor cells (SK-BR-3) EGF causes a rapid increase in tyrosine phosphorylation of the erbB-2 protein. Phosphorylation of
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8. Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development
The ErbB2 tyrosine kinase functions as coreceptor for the neuregulin receptors ErbB3 and ErbB4 and can participate in signaling of EGF receptor (ErbB1), interleukin receptor gp130, and G-protein coupled receptors. ErbB2−/− mice die at midgestation because of heart malformation. Here, we report a genetic rescue of their heart development by myocardial exp
Cold Spring Harbor Laboratory Press.
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9. Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers
The four members of the ErbB family of receptor tyrosine kinases are involved in a complex array of combinatorial interactions involving homo- and heterodimers. Since most cell types express more than one member of the ErbB family, it is difficult to distinguish the biological activities of different homo- and heterodimers. Here we describe a method for indu
American Society for Microbiology.
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10. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
Overexpression of the transmembrane receptor tyrosine kinase ErbB2 is common in multiple malignancies, including breast and ovarian cancer. ErbB2 is resistant to degradation mediated by c-Cbl, the E3 ubiquitin ligase responsible for ligand-induced ubiquitination of ErbB1 (epidermal growth factor receptor). Because of its resistance to degradation, ErbB2 is t
The National Academy of Sciences.
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11. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
ErbB2 is a receptor tyrosine kinase whose activity in normal cells depends on dimerization with another ligand-binding ErbB receptor. In contrast, amplification of c-erbB2 in tumors results in dramatic overexpression and constitutive activation of the receptor. Breast cancer cells overexpressing ErbB2 depend on its activity for proliferation, because tr
National Academy of Sciences.
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12. Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics.
We have compared the protein tyrosine kinase activities of the chicken epidermal growth factor receptor (chEGFR) and three ErbB proteins to learn whether cancer-activating mutations affect the kinetics of kinase activity. In immune complex assays performed in the presence of 15 mM Mn2+, ErbB proteins and the chEGFR exhibited highly reproducible tyrosine kina