Prostate Apoptosis Response 4
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Functional study of gene PAWR/Par-4 (Prostate apoptosis response-4) in normal and cancer breast cells / Estudo funcional do gene PAWR/Par-4 (Prostate apoptosis responde-4) em células de mama normais e tumorais
O câncer de mama é o tumor mais incidente entre as mulheres no mundo. Assim como em outros tumores, a tumorigênese nas mamas é um processo complexo resultante da combinação de fatores genéticos e ambientais que dirigem a transformação das células normais em células malignas. O gene PAWR, conhecido como PAR-4 (Prostatic apoptosis response-4) foi pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/06/2012
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2. Estudo dos genes NDRG1, Par-4, osteonectina e pontina, em tecido mamário hiperplásico através de técnica de imunohistoquímica / Study of NDRG1, Par-4, osteonectin and pontin expression in hyperplastic breast lesions with immunohistochemical technique
INTRODUCTION: Breast cancer is a leading cause of death among women all over the Word. Proliferative lesions of the breast are believed to be precursors of or markers of increased risk for breast carcinoma. Although the active research in the field of breast cancer, the early molecular events associated with cancer evolution and progression are still poorly
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/05/2011
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3. Influência da hiperglicemia e do estresse oxidativo na cinética de proliferação e morte celular no epitélio acinar da próstata de ratos diabéticos / The influence of hyperglycemia and oxidative stress in proliferation and cell death kinetics in prostate acinar epithelium of diabetic rats
The diabetes damages in prostate morphophysiology are well known and are triggered by insulin lack, low androgen levels and hyperglycemia. Previous researches showed an individual variation in morphological prostate response against this disease. In order to clarify the factors responsible for this variation, we examined the correlation between histological
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2011
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4. An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines
OBJECTIVE: The aim of our study is to investigate the anti-neoplastic effect of curcumin in prostate cancer cell lines. Specifically, we are using the LNCaP cell line and another prostate cell line developed in our laboratory, PcBra1. The PcBra1 cells were derived from a localized, obstructive prostate cancer with a Gleason score of 9 (4+5). MATERIAL AND MET
International braz j urol. Publicado em: 2009-06
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5. Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat.
Although dihydrotestosterone (DHT) is the principal androgen in the prostate, testosterone can also act as an androgen in this tissue. To determine the relative potencies of testosterone and DHT in preventing prostate regression, castrated rats were implanted for 4 d with varying doses of testosterone in the presence or absence of the 5alpha-reductase inhibi
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6. Expression and function of the leucine zipper protein Par-4 in apoptosis.
The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein wit
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7. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.
The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. In this study, we identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a transcriptional repressor. par-4 contains a putative leucine zipper d
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8. Par4 is a coactivator for a splice isoform–specific transcriptional activation domain in WT1
The Wilms' tumor suppressor protein WT1 is a transcriptional regulator involved in differentiation and the regulation of cell growth. WT1 is subject to alternative splicing, one isoform including a 17–amino acid region that is specific to mammals. The function of this 17–amino acid insertion is not clear, however. Here, we describe a transcriptional acti
Cold Spring Harbor Laboratory Press.
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9. The Wilms’ Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression during Gonadal Differentiation
Gonadal differentiation is dependent upon a molecular cascade responsible for ovarian or testicular development from the bipotential gonadal ridge. Genetic analysis has implicated a number of gene products essential for this process, which include Sry, WT1, SF-1, and DAX-1. We have sought to better define the role of WT1 in this process by identifying downst
American Society for Microbiology.