Prostaglandin And Antioxidant
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
The risks of cancer and other degenerative diseases caused by reactive oxygen species and electrophiles can be reduced by the up-regulation of detoxifying enzymes. A major mechanism whereby these protective enzymes are induced occurs through activation of the antioxidant response element (ARE) by the oxidative-stress sensor protein Kelch-like ECH-associated
National Academy of Sciences.
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14. Localization of distinct F2-isoprostanes in human atherosclerotic lesions.
F2-Isoprostanes are prostaglandin (PG) isomers formed in situ in cell membranes by peroxidation of arachidonic acid. 8-epi PGF2alpha and IPF2alpha-I are F2-isoprostanes produced in humans which circulate in plasma and are excreted in urine. Measurement of F2-isoprostanes may offer a sensitive, specific, and noninvasive method for measuring oxidant stress in
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15. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells
Cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E2 (PGE2) plays a key role in inflammation and its associated diseases, such as cancer and vascular heart disease. Here we report that γ-tocopherol (γT) reduced PGE2 synthesis in both lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and IL-1β-treated A549 human epithelial cells wit
The National Academy of Sciences.