Promiscuous Gene Expression
Mostrando 1-12 de 50 artigos, teses e dissertações.
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1. Pipeline para Análise In Sílico de Dados de Expressão de miRNAs e mRNAs em Células de Mamíferos. / Pipeline for in silico Analysis of miRNAs and mRNAs Expression Data in Mammals Cells.
Os microRNAs estão envolvidos no processo de regulação da expressão gênica da célula, onde a molécula de microRNA se liga com o RNA mensageiro interrompendo, assim, a expressão do respectivo gene pela interrupção da tradução. A bioinformática tem auxiliado na identificação de vários genes codificadores de microRNAs em plantas e animais, inclu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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2. Analysis of the promiscuous gene expression in the thymus of NOD (non obese diabetic) mice during onset of type 1 diabetes mellitus / Análise da expressão gênica promíscua no timo de camundongos NOD (non obese diabetic) durante a emergência do Diabetes melitus tipo 1
Immunologic tolerance is an essential property of the immune system, which controls immune reactions directed against the body self components. The thymus is seen as the main organ involved with the tolerance induction to self antigens, which are expressed by the thymic cells (central tolerance), while the tolerance induction to the diverse other peripheral
Publicado em: 2008
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3. Promiscuous gene expression in medullary thymic epithelial cells is connected in network where the Aire gene is an upstream modulator / O papel modulador do gene Aire (autoimmune regulator) sobre redes de expressão gênica em células tímicas epiteliais medulares
The expression of tissue restricted antigens (TRAs) in thymus by medullary thymic epithelial cells (mTECs) is essential for the central selftolerance of T cells. Due to heterogeneity of autoantigen representation this phenomenon has been termed promiscuous gene expression (PGE), in which the autoimmune regulator (Aire) gene plays a role as main positive tran
Publicado em: 2008
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4. Aspectos moleculares da evolução do gene DARC em primatas / Molecular aspects of DARC gene evolution in primates
Genes involved in pathogen-host interactions are strongly affected by positive natural selection. The gene of blood Duffy antigen, also known as DARC (Duffy Antigen Receptor for Chemokines), has an important role in the invasion of red blood cells by the parasites that cause malaria, Plasmodium vivax in humans and Plasmodium knowlesi in other primates. The s
Publicado em: 2008
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5. Análise do transcriptoma durante a ontogenia do timo. / Analysis of the transcriptoma during the antogenia of the thymus.
The thymus is a complex organ structured by a stroma, which is formed mainly by cortical epithelial cells (cTECs) and medullary epithelial cells (mTECs) besides of other cell types such as dendritic cells (DC), macrophages, B lymphocytes and fibroblasts. Moreover, the T cell precursors arising from the bone marrow reach the thymus (thymocytes) maturing in T
Publicado em: 2007
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6. The Vaccinia Virus A18R DNA Helicase Is a Postreplicative Negative Transcription Elongation Factor
Loss of vaccinia virus A18R gene function results in an aberrant transcription profile termed promiscuous transcription, defined as transcription within regions of the genome which are normally transcriptionally silent late during infection. Promiscuous transcription results in an increase in the intracellular concentration of double-stranded RNA, which in t
American Society for Microbiology.
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7. The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts Physically and Functionally with Histone Acetyltransferase P/CAF
The major immediate-early proteins of human cytomegalovirus (HCMV) play a pivotal role in controlling viral and cellular gene expression during productive infection. As well as negatively autoregulating its own promoter, the HCMV 86-kDa major immediate early protein (IE86) activates viral early gene expression and is known to be a promiscuous transcriptional
American Society for Microbiology.
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8. The replication initiator operon of promiscuous plasmid RK2 encodes a gene that complements an Escherichia coli mutant defective in single-stranded DNA-binding protein.
The amino acid sequence of the 13-kDa polypeptide (P116) encoded by the first gene of the trfA operon of IncP plasmid RK2 shows significant similarity to several known single-stranded DNA-binding proteins. We found that unregulated expression of this gene from its natural promoter (trfAp) or induced expression from a strong heterologous promoter (trcp) was s
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9. Future of adenoviruses in the gene therapy of arthritis
Recombinant adenoviruses are straightforward to produce at high titres, have a promiscuous host-range, and, because of their ability to infect nondividing cells, lend themselves to in vivo gene delivery. Such advantages have led to their widespread and successful use in preclinical studies of arthritis gene therapy. While adenoviral vectors are well suited t
BioMed Central.
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10. korA function of promiscuous plasmid RK2: an autorepressor that inhibits expression of host-lethal gene kilA and replication gene trfA.
In broad host-range plasmid RK2, korA function prevents the lethal effect of kilA on Escherichia coli host cells and inhibits expression of trfA, the essential replication gene. From gene fusion and promoter replacement studies, we determined that control of kilA is also mediated at the level of gene expression and that the target resides in the kilA promote
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11. Promiscuous trans activation of gene expression by an Epstein-Barr virus-encoded early nuclear protein.
We identified an Epstein-Barr virus (EBV) gene product which functions in transient-expression assays as a nonspecific trans activator. In Vero cells, cotransfection of the BglII J DNA fragment of EBV together with recombinant constructs containing the bacterial chloramphenicol acetyltransferase (CAT) gene gave up to a 100-fold increased expression of CAT ac
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12. Widespread expression of MyoD genes in Xenopus embryos is amplified in presumptive muscle as a delayed response to mesoderm induction.
The MyoD gene codes for an important regulatory factor in skeletal myogenesis. To explore the relationship between mesoderm induction in Xenopus embryos and expression of MyoD, I have monitored MyoD mRNA levels in normal embryos and cultured explants by RNase protection. Transcription from the two Xenopus MyoD gene copies is activated weakly across the whole