Promastigote Viability
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological scr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/10/2018
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2. Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis
Abstract Background: Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins production, few studies have inve
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
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3. Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon
Abstract INTRODUCTION Maytenus guianensis is a member of the Celastraceae family that is used in traditional medicine, particularly for its anti-parasitic and anti-cancer effects. To explore the ethnopharmacological potential of this plant, the present study was designed to screen the in vitro antileishmanial activities of extracts and compounds isolated fr
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-10
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4. Efeito de uma fosfolipase A2 básica isolada da peçonha de Bothropoides pauloensis (Bothrops pauloensis) sobre formas promastigota de Leishmania (Leishmania) amazonensis
CHAPTER 2: Leishmaniasis is a group of diseases caused by protozoa of Leishmania genus. The currently available treatment for this disease presents high toxicity and cost, parasite resistance, and difficulties of healing. In this sense, the development of new strategies for treatment of leishmaniasis is indispensable and snake venoms appear as an important n
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011
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5. Assessment of Leishmania major and Leishmania braziliensis promastigote viability after photodynamic treatment with aluminum phthalocyanine tetrasulfonate (AlPcS4)
Cutaneous leishmaniasis is an infectious disease caused by protozoans of the genus Leishmania, which is transmitted through the bite of hematophagous insects of the genus Lutzomyia. This study aimed at testing in vitro the phototoxic effect of aluminum phthalocyanine tetrasulfonate (AlPcS4) on the viability of Leishmania major and Leishmania braziliensis. St
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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6. Efeito da peçonha de Bothrops moojeni sobre formas promastigotas de Leishmania spp
In order to develop alternative tools to subdue infectious diseases, several substances have been tested toward treatment of parasitoses, such as Leishmaniasis. For this purpose, snake venoms have been used as future drugs that disrupt the viability of protozoan. In this report, we evaluated the effect of Bothrops moojeni venom and its fractions on viability
Publicado em: 2008
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7. Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite.
In Leishmania major a 100-kDa heat shock protein, Hsp100, is abundant in the intracellular amastigote stage which persists in the mammalian host. A replacement of both clpB alleles which encode Hsp100 does not affect promastigote viability under standard culture conditions but impairs thermotolerance in vitro. In experimental infections of BALB/c inbred mice
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8. A novel role for 100 kD heat shock proteins in the parasite Leishmania donovani
Heat shock proteins of the 100 kD family have been known to confer general stress tolerance in yeast and plants. Several protozoan parasites possess genes for Hsp100 proteins. In Leishmania species the protein is expressed under heat stress and during the mammalian stage, the amastigote. We show here that replacement of the clpB gene which encodes Hsp 100 do
Cell Stress Society International.
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9. Antileishmanial activity of chlorpromazine.
The antiprotozoal activity of chlorpromazine against the pathogenic protozoan Leishmania donovani, in both its amastigote and promastigote stages, was characterized. Chlorpromazine at concentrations greater than or equal to 3.12 micrograms/ml (9.8 X 10(-6) M) produced a significant reduction in viable promastigotes. The minimal protozoacidal concentration fo
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10. Response of Leishmania chagasi promastigotes to oxidant stress.
At the onset of infection, Leishmania promastigotes are phagocytized by mammalian macrophages. They must survive despite exposure to toxic oxidants such as hydrogen peroxide (H2O2) and superoxide (.O2-) generated during phagocytosis. We investigated the effects of these oxidants on Leishmania chagasi promastigotes and promastigote mechanisms for oxidant resi
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11. Genetic characterization of glucose transporter function in Leishmania mexicana
Both insect and mammalian life cycle stages of Leishmania mexicana take up glucose and express all three isoforms encoded by the LmGT glucose transporter gene family. To evaluate glucose transporter function in intact parasites, a null mutant line has been created by targeted disruption of the LmGT locus that encompasses the LmGT1, LmGT2, and LmGT3 genes. Th
The National Academy of Sciences.
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12. Ultrastructural and Biochemical Alterations Induced by 22,26-Azasterol, a Δ24(25)-Sterol Methyltransferase Inhibitor, on Promastigote and Amastigote Forms of Leishmania amazonensis
We report on the antiproliferative effects and the ultrastructural and biochemical alterations induced in vitro by 22,26-azasterol, a sterol Δ24(25)-methyltransferase (24-SMT) inhibitor, on Leishmania amazonensis. When promastigotes and amastigotes were exposed to 100 nM 22,26-azasterol, complete growth arrest and cell lysis ensued after 72 (promastigotes)
American Society for Microbiology.