Prime Boost
Mostrando 1-12 de 78 artigos, teses e dissertações.
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1. Evaluation of pathogen P21 protein as a potential modulator of the protective immunity induced by Trypanosoma cruzi attenuated parasites
BACKGROUND TcP21 is a ubiquitous secreted protein of Trypanosoma cruzi and its recombinant form (rP21) promotes parasite cell invasion and acts as a phagocytosis inducer by activating actin polymerisation in the host cell. OBJECTIVE Our goal was to evaluate if the additional supplementation of rP21 during a prime/boost/challenge scheme with T. cruzi TCC
Mem. Inst. Oswaldo Cruz. Publicado em: 20/05/2019
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2. DNA prime-protein boost based vaccination with a conserved region of leptospiral immunoglobulin-like A and B proteins enhances protection against leptospirosis
Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of theLeptospira genus. Vaccination with bacterins has severe limitations. Here, we evaluated the N-terminal region of the leptospiral immunoglobulin-like B protein (LigBrep) as a vaccine candidate against leptospirosis using immunisation strategies based on DNA prime-protein boost, DNA vac
Mem. Inst. Oswaldo Cruz. Publicado em: 11/12/2015
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3. Alzheimer's disease: is a vaccine possible?
The cause of Alzheimer's disease is still unknown, but the disease is distinctively characterized by the accumulation of β-amyloid plaques and neurofibrillary tangles in the brain. These features have become the primary focus of much of the research looking for new treatments for the disease, including immunotherapy and vaccines targeting β-amyloid in the
Braz J Med Biol Res. Publicado em: 2014-06
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4. Recombinant vaccines and the development of new vaccine strategies
Vaccines were initially developed on an empirical basis, relying mostly on attenuation or inactivation of pathogens. Advances in immunology, molecular biology, biochemistry, genomics, and proteomics have added new perspectives to the vaccinology field. The use of recombinant proteins allows the targeting of immune responses focused against few protective ant
Braz J Med Biol Res. Publicado em: 2012-12
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5. Avaliação de estratégias de vacinação \"prime-boost\" na infecção experimental por Schistosoma mansoni empregando vacinas de DNA / Evaluation of prime-boost vaccination strategies against Schistosoma mansoni experimental infection applying DNA vaccines.
A esquistossomose é uma das mais relevantes doenças induzidas por helmintos, acometendo cerca de 207 milhões de pessoas em todo o mundo. O Praziquantel e o Oxamniquine são os fármacos empregados no tratamento, mas além de não impedirem re-infecções, não atuam nos estágios imaturos do verme. Portanto, o desenvolvimento de uma estratégia de vacina�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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6. Synergism/complementarity of recombinant adenoviral vectors and other vaccination platforms during induction of protective immunity against malaria
The lack of immunogenicity of most malaria antigens and the complex immune responses required for achieving protective immunity against this infectious disease have traditionally hampered the development of an efficient human malaria vaccine. The current boom in development of recombinant viral vectors and their use in prime-boost protocols that result in en
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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7. Prevenção e controle do Vaccinia virus no Brasil: padronização de um sistema prime-boost para imunização e determinação de seus hospedeiros naturais
A família Poxviridae compreende grandes e complexos vírus de animais, capazes de infectar hospedeiros vertebrados e invertebrados. Orhopoxvirus (OPXV) é um dos gêneros da família, e entre os seus representantes estão o Cowpox virus, o Monkeypox virus, o Variola virus e o Vaccinia virus (VACV). O VACV é o agente causador 5 da vaccínia bovina no Brasil
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/12/2010
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8. Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection
Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. Leukotrienes have also been associated with protection against infectious diseases. However, the role of leukotrienes in Mycobacterium tuberculosis infection is not
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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9. Immune strategies using single-component LipL32 and multi-component recombinant LipL32-41-OmpL1 vaccines against leptospira
Genes encoding lipoproteins LipL32, LipL41 and the outer-membrane protein OmpL1 of leptospira were recombined and cloned into a pVAX1 plasmid. BALB/c mice were immunized with LipL32 and recombined LipL32-41-OmpL1 using DNA-DNA, DNA-protein and protein-protein strategies, respectively. Prime immunization was on day 1, boost immunizations were on day 11 and da
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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10. Study of the potential of adjuvants toxoids Stx1 and Stx2 of Escherichia coli on native outer membrane vesicle preparations of Neisseria meningitidis B in BALB/c mice / Estudo do potencial adjuvante dos toxóides Stx1 e Stx2 de Escherichia coli em preparações com antígenos de vesículas de membrana externa de Neisseria meningitidis B em camundongos BALB/c
As vacinas antimeningocócicas têm se demonstrado efetivas contra os sorogrupos A e C, no entanto ainda não existe vacina contra o sorogrupo B devido à similaridade entre a estrutura capsular do polissacáride B e o ácido polisiálico que faz parte do tecido cerebral humano, podendo levar à autoimunidade. O objetivo deste estudo foi investigar as propri
Publicado em: 2009
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11. Role of leukotrienes in immune protection conferred by the heterologous immunization BCG/DNA-HSP65 against tuberculosis / Papel dos leucotrienos na proteção conferida pela imunização heteróloga BCG/DNA-HSP65 contra tuberculose
Tuberculosis is responsible for more than 2 millions of death for year. The immune response against tuberculosis is related to activation of IFN-g-producing CD4+ and CD8+ cells. IFN-g increases the microbicidal mechanisms of macrophages to kill intracellular bacilli. Recently, the lipid mediator leukotriene B4 (LTB4) has been related to protection against se
Publicado em: 2009
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12. Nasal immunization with outer membrane antigens of Neisseria meningitidis B selected for the highest expression of the immunotype of LPS 3,7,9 with monoclonal antibodies and Bordetella pertussis as adjuvants in neonates mice. / Imunização nasal com antígenos de membrana externa de Neisseria meningitidis B selecionados para a maior expressão do imunotipo de LPS 3, 7, 9 com anticorpos monoclonais e Bordetella pertussis como adjuvante em camundongos neonatos.
The natural habitat of Neisseria meningitidis is the human nasopharynx, and the bacterium is transmitted by direct mouth-to-mouth contact or by the inhalation of released mucous particles during close contact. N meningitidis is a Gram-negative bacterium responsible for significant mortality worldwide. While effective polysaccharide-based vaccines exist again
Publicado em: 2008