Primary Immunodeficiencies
Mostrando 13-24 de 31 artigos, teses e dissertações.
-
13. Estudo genetico-molecular da doença granulomatosa cronica
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by ear1y onset recurrent severe infections. The molecular defects causing CGD are generally due to the absence, low expression or malfunctioning of one of the NADPH oxidase components. This work analyzed the potential use of reverse transcription (RT)PCR for screening molecu
Publicado em: 2004
-
14. Aspectos clinicos de pacientes sob suspeita de imunodeficiencia fagocitaria
Recurrent infections are ftequently referred to the Pediatrician s office. As the irnrnune system continues to develop after birth and will be completed just after childhood, infants tend to present more infections. Besides this particular characteristic, Pediatricians should be aware to some abnormal conditions, the primary immunodeficiencies. Among the pri
Publicado em: 2003
-
15. Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
American Society for Clinical Investigation.
-
16. Relations between Immunity and Malignancy
A higher incidence of malignancy as well as greater susceptibility to infection has been found to be associated with primary immunodeficiencies. An increased incidence of leukemia has been associated with X-linked infantile agammaglobulinemia-an isolated defect of humoral immunities. An increased frequency of a wide variety of malignancies have been found to
-
17. The European internet-based patient and research database for primary immunodeficiencies: results 2006–2008
Primary immunodeficiencies (PID) are rare diseases; therefore transnational studies are essential to maximize the scientific outcome and to improve diagnosis and therapy. In order to estimate the prevalence of PID in Europe as well as to establish and evaluate harmonized guidelines for the diagnosis and treatment of PID, the European Society for Immunodefici
Blackwell Science Inc.
-
18. Modulatory effects on immunoglobulin synthesis and secretion by lymphocytes from immunodeficient patients.
Incubation of peripheral lymphocytes (PBL) from normal donors with pokeweek mitogen (PWM) induced terminal differentiation by B lymphocytes to immunoglobulin (Ig) synthesizing and secreting plasma cells. B cells from hypogammaglobulinemic patients with different primary immunodeficiencies failed to undergo functional differentiation after similar treatment w
-
19. Novel antibody switching defects in human patients
Hyper-IgM syndrome (HIGM) is a primary immunodeficiency characterized by normal to elevated serum levels of IgM and low levels or the absence of IgG, IgA, and IgE. A new study AID expression in nonlymphoid cells (see related article on pages 136–142) characterizes HIGM type 4, a previously undocumented defect in antibody gene diversification caused by a se
American Society for Clinical Investigation.
-
20. Community-Acquired Poliovirus Infection in Children with Primary Immunodeficiencies in Tunisia
The global polio eradication program recommends the use of massive vaccination campaigns with live vaccine through National Immunization Days (NIDs) to displace the wild virus from the community. Immunodeficient patients may be indirectly infected and become chronic excretors and potential reservoirs of polioviruses, a concern for the posteradication era. Th
American Society for Microbiology.
-
21. Prevention of development of autoimmune disease in BXSB mice by mixed bone marrow transplantation
Transplantations of fully allogeneic, autoimmune-resistant T-cell-depleted marrow (TCDM) plus syngeneic, autoimmune-prone TCDM into lethally irradiated BXSB mice were carried out to investigate the ability of the mixed bone marrow transplantation (BMT) to prevent development of autoimmune disease and, at the same time, to reconstitute fully the immunity func
The National Academy of Sciences of the USA.
-
22. Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes.
The in vitro incubation of phytohemagglutinin-stimulated peripheral blood lymphocytes with thymosin results in a marked and reproducible increase in production of T-cell growth factor, which is dose dependent and most pronounced in the first 24 hr of culture. Incubation of lymphocytes with thymosin alone failed to induce any production of T-cell growth facto
-
23. Leukocyte migration inhibitory factor (LMIF) induced by concanavalin A: standardized microassay for production in vitro.
A standardized microculture system has been developed to assess the ability of lymphocytes to secrete leukocyte migration inhibitory factor (LMIF) in response to the nonspecific mitogen concanavalin(Con A). LMIF-rich supernates collected from stimulated lymphocytes cultured in plastic microtiter plates are assayed by pulse exposure of purified human granuloc
-
24. The majority of cells infected with the defective murine AIDS virus belong to the B-cell lineage.
Murine AIDS (MAIDS) is caused by a defective retrovirus which encodes a gag fusion protein (Pr60gag). We previously reported that this virus induced an oligoclonal proliferation of infected cells and suggested that this cell expansion was an important event in the pathogenesis of MAIDS. To identify these target cells, we constructed novel defective viruses w