Praziquantel
Mostrando 25-36 de 147 artigos, teses e dissertações.
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25. Esquistossomose endocervical: relato de caso
A esquistossomose mansoni, endemia encontrada em diferentes áreas do território brasileiro, constitui um grave problema de saúde pública no Brasil e no mundo. Formas ectópicas da doença podem acometer o sistema reprodutor feminino, constituindo um tipo raro de infecção pelo S. mansoni. Paciente com 26 anos queixava-se de corrimento vaginal, dispareun
Rev. Bras. Ginecol. Obstet.. Publicado em: 2014-06
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26. Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection
Mice infected with Schistosoma mansoni were treated with oxamniquine, praziquantel, artesunate at the pre-patent phase, aiming at observing schistogram alterations. Half of the animals were perfused five days post-treatment for counting and classification of immature worms, based on pre-established morphological criteria (schistogram); the remaining animals
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-11
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27. A Microtus fortisprotein, serum albumin, is a novel inhibitor of Schistosoma japonicumschistosomula
Schistosomiasis is an endemic parasite disease and praziquantel is the only drug currently in use to control this disease. Experimental and epidemiological evidence strongly suggests that Microtus fortis( Mf) is a naturally resistant vertebrate host of Schistosoma japonicum. In the present study, we found that Mfserum albumin ( Mf-albumin) and the conditione
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-11
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28. Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms
Current schistosomiasis control strategies are largely based on chemotherapeutic agents and a limited number of drugs are available today. Praziquantel (PZQ) is the only drug currently used in schistosomiasis control programs. Unfortunately, this drug shows poor efficacy in patients during the earliest infection phases. The effects of PZQ appear to operate o
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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29. Anal polyp caused by Schistosoma mansoni
We describe a schistosomal polyp in the anus of a 24-year-old patient, born in Viçosa, State of Minas Gerais, and living in Belo Horizonte, State of Minas Gerais. From 8 to 13 years of age, he swam in the rivers that bathe Viçosa. The histopathological examination has shown a lesion, lined by a keratinized squamous epithelium, ulcerated, with granulomas, c
Rev. Soc. Bras. Med. Trop.. Publicado em: 2013-04
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30. Preparation and characterisation of Dextran-70 hydrogel for controlled release of praziquantel
Um hidrogel foi desenvolvido a partir de dextrano 70 kDa (DEX-70) e praziquantel incorporado (PZQ) como fármaco modelo. Propriedades biofarmacêuticas, como solubilidade e velocidade de dissolução, foram analisadas no desenvolvimento do hidrogel. Além disso, o hidrogel também foi caracterizado por espectroscopia na região do infravermelho e calorimetri
Braz. J. Pharm. Sci.. Publicado em: 2013-03
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31. Ação de cordia verbenacea sobre schistosoma mansoni / Activity of cordia verbenacea on schistosoma mandoni
The trematode Schistosoma mansoni is responsible for causing a form of schistosomiasis that kills around 280,000 people each year. Since there are cases of tolerance and resistance to the drugs currently used in the treatment for this disease, namely praziquantel (PZQ) and oxamniquine, there is a need for new schistosomicidal drugs. In that regard, the resea
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/01/2012
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32. Avaliação de estratégias de vacinação \"prime-boost\" na infecção experimental por Schistosoma mansoni empregando vacinas de DNA / Evaluation of prime-boost vaccination strategies against Schistosoma mansoni experimental infection applying DNA vaccines.
A esquistossomose é uma das mais relevantes doenças induzidas por helmintos, acometendo cerca de 207 milhões de pessoas em todo o mundo. O Praziquantel e o Oxamniquine são os fármacos empregados no tratamento, mas além de não impedirem re-infecções, não atuam nos estágios imaturos do verme. Portanto, o desenvolvimento de uma estratégia de vacina�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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33. In vitro schistosomicidal effects of the essential oil of Tagetes erecta
The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected in Brazil against Schistosoma mansoni worms are reported in this paper. The oil caused a significant decrease in the motor activity at 50 µg/mL as minimal concentration after 24 h. This oil also caused death of all the parasites an
Revista Brasileira de Farmacognosia. Publicado em: 16/11/2011
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34. Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
Praziquantel (PZQ) is currently the only drug widely used for the treatment of schistosomiasis, but the antimalarial drug mefloquine (Mef) possesses interesting antischistosomal properties. Combination therapy with these two drugs has been suggested as a strategy for transmission control, as PZQ is active against adult worms and Mef is active against schisto
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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35. Chromatin regulation in schistosomes and histone modifying enzymes as drug targets
Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in particular the histone acetyltransferases and
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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36. Efeitos terapêuticos do Allium sativum e Allium cepa na infecção experimental pelo Schistosoma mansoni
Os efeitos do alho (Allium sativum) e cebola (Allium cepa) em parâmetros bioquímicos de camundongos infectados pelo Schistosoma mansoni individualmente e misturados seja com ou sem as drogas correntemente usadas como o Praziquantel (PZQ), foram investigados. Isto envolveu parâmetros imunológicos tais como IgM, IgG, Interleucina 2 e 6 (IL-2 e 6), fator de
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2011-06