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Mostrando 13-20 de 20 artigos, teses e dissertações.
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13. Modelo experimental de mucosite oral induzida por radioterapia de megavoltagem â papel protetor da pentoxifilina / Experimental model of oral mucositis radio-induced by megavoltage â the protective role of the pentoxyfilline
A mucosite ou estomatite oral (MO), que consiste na resposta inflamatÃria da mucosa oral à aÃÃo de drogas ou radioterapia, onstitui-se num efeito colateral debilitante, sendo uma complicaÃÃo potencialmente sÃria, dose-limitante que tem impacto tanto no controle local quanto na sobrevida e qualidade de vida de pacientes oncolÃgicos. O objetivo deste t
Publicado em: 2006
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14. Skin tumor promotion by phorbol esters is a two-stage process.
In the semisynthetic compound phorbol 12-retinoate 13-acetate (PRA), the antipromoting principle of vitamin A acid is combined with the structure of a phorbol ester tumor promoter. In skin of NMRI mice, a single topical application of PRA induces skin inflammation, epidermal proliferation, and sustained hyperplasia to a similar extent and apparently along th
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15. Localization within a Proline-Rich Antigen (Ag2/PRA) of Protective Antigenicity against Infection with Coccidioides immitis in Mice
Subunits of a proline-rich coccidioidal antigen (Ag2/PRA) of Coccidioides immitis were analyzed by comparison as vaccines in mice. The optimal dose of plasmid vaccine encoding full-length Ag2/PRA was determined to be between 10 and 100 μg. Mice vaccinated with plasmids encoding amino acids (aa) 1 to 106 were as protective as full-length Ag2/PRA (aa 1 to 194
American Society for Microbiology.
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16. Role of Signal Sequence in Vaccine-Induced Protection against Experimental Coccidioidomycosis
The vaccine efficacy of the gene sequence encoding the signal peptide of the antigen known as antigen 2 or proline-rich antigen (Ag2/PRA), an immunodominant antigen present in the cell wall of the fungal pathogen Coccidioides immitis, was investigated in a murine model of coccidioidomycosis. Expression plasmids for Ag2/PRA(1-18) DNA (signal sequence), Ag2/PR
American Society for Microbiology.
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17. Renal electrolyte excretion and renin release during calcium and parathormone infusions in conscious rabbits.
Following a random block experimental design in each case, three repeated measurement studies were carried out in three different groups of conscious rabbits, to investigate the renal effects of increasing doses of intravenous calcium chloride (CaCl2) and bovine parathyroid hormone (PTH). In the first study, each rabbit received either CaCl2 (0.15, 0.3, 0.5
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18. An effect of extrarenal beta adrenergic stimulation on the release of renin
The present study was undertaken to examine whether the beta adrenergic agonist, isoproterenol, increases plasma renin activity (PRA) by activation of intrarenal or extrarenal pathways. The effects of intravenous (i.v.) and renal arterial infusion of isoproterenol on PRA and renin secretion rate (RSR) were compared in anesthetized dogs. In 12 studies in 9 do
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19. Effects of neuropeptide-Y on renal function and its interaction with sympathetic stimulation in conscious dogs.
1. The effects of neuropeptide-Y (NPY) on renal function were investigated in conscious foxhounds. 2. Dose-response curves (n = 7) were obtained for NPY by measuring renal blood flow (RBF), glomerular filtration rate (GFR), urine excretion (VU), sodium excretion (VNa), potassium excretion (VK) and plasma renin activity (PRA) at different infusion rates. All
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20. Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms.
Lipopolysaccharide (LPS) treatment of monocytic cells has been shown to activate the Raf-1/mitogen-activated protein kinase (MAPK) signaling pathway and to increase secretory interleukin-1 receptor antagonist (sIL-1Ra) gene expression. The significance of the activation of the Raf-1/MAPK signaling pathway to LPS regulation of sIL-1Ra gene expression, however