Ppar Alpha
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Effect of Cottonseed Meal Fermented with Yeast on the Lipid-related Gene Expression in Broiler Chickens
ABSTRACT Fermented cottonseed meal (FCSM) is widely used in poultry diets in China. This study was conducted to investigate the effect of FCSM on lipid-related gene expression in broilers. Initially, 180 broiler chickens (21-days-old, equal number of males and females) were randomly divided into three groups, with six pens per group and 10 birds per pen. The
Rev. Bras. Cienc. Avic.. Publicado em: 2015-12
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2. Fenofibrato (agonista do receptor ativador da proliferação peroxissomal) modula o sistema renina-angiotensina no coração de camundongos alimentados com dieta hiperlipídica / Fenofibrate (peroxisome proliferator-activated receptor alpha agonist) modulates the renin-angiotensin system in the heart of mice fed with a high-fat diet
The aim was to study the action of fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, in cardiac remodeling and protein expressions of RAS components in a model of obesity induced by diet. 3-mo-old C57BL/6 male were fed for 11 weeks with standard chow (SC group, 3.57 kcal/g of chow) or high-fat chow (HF group, 5.40 kcal/g of chow), then
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/03/2012
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3. Estudos estruturais do receptor ativado por ativadores de peroxissomos humano, hPPARδ / Structural studies of human peroxisome proliferator activated receptor, hPPARδ
Os PPARs são fatores de transcrição ativados por ligantes, pertencentes à superfamília dos receptores nucleares, que são considerados sensores de lipídeos capazes de transformar alterações nos padrões de lipídeos/ácidos graxos dos organismos em atividade metabólica. Com isto, os 3 isotipos (α, δ e γ) estão associados a diferen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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4. Remodelamento do fígado, pâncreas e tecido adiposo em modelo experimental de síndrome metabólica tratado com telmisartana, sitagliptina e metformina / Hepatic, pancreatic and adipose tissue remodeling in an experimental model of metabolic syndrome treated with telmisartan, sitagliptin and metformin
Pharmacological intervention can minimize or even reverse adverse remodeling due to metabolic syndrome. This work sought to evaluate the effects of monotherapies and combinations of drugs on insulin sensitivity, adipose tissue morphology, pancreatic and hepatic remodelling in C57BL/6 mice fed a high-fat diet. Male C57BL/6 mice were fed a very high-fat diet (
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/06/2010
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5. O processo inflamatório após a indução de infarto agudo do miocárdio é atenuado por treinamento físico prévio em ratos - análise dos mecanismos de cardioproteção induzida com o exercício / The inflammatory process after induced myocardial infarcts in rats is attenuated by previous exercise: analysis of the mechanisms of cardioprotection induced with the exercise
O exercício é hoje reconhecidamente um fator de proteção para morbidade e mortalidade cardiovascular. Apesar de extensos dados de estudos epidemiológicos e de intervenção, os mecanismos subjacentes cardioprotetores do exercício ainda não estão bem elucidados. Alguns autores acreditam que o treinamento físico induz o desenvolvimento de células mio
Publicado em: 2010
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6. Interections between CD40/CD40L and PPARs signaling pathways / Interação entre as vias de sinalização CD40/CD40L e os PPARs
The membrane receptor CD40 and its ligand CD40L play an important role in the interface between innate and acquired immunity. Dysfunction of this signaling pathway was described in inflammatory and autoimmune diseases. In systemic lupus erythematosus (SLE), increased serum levels of soluble CD40L have been detected, where it plays a significant role in the g
Publicado em: 2008
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7. Efeito de acidos graxos n-3 e n-6 sobre a expressão e atividade da proteina de transferencia de colesteril ester (CETP) em camundongos transgenicos / Effects of n-3 and n-6 fatty acids on the cholesteryl ester transfer protein (CETP) expression and activity in transgenic mice
Os óleos de peixe e de milho são fontes de ácidos graxos poli-insaturados (PUFA) n-3 e n-6, respectivamente. Estes ácidos graxos são ligantes naturais dos receptores ativados por proliferadores de peroxissomos (PPARs) e, dessa forma, modificam a expressão de diversos genes envolvidos no metabolismo de lipídios. A proteína de transferência de coleste
Publicado em: 2008
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8. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the ligand-binding domain of the alpha isoform of mouse PPAR (mPPAR alpha) by homologous recombination. Mice homozygous for the mutation lack expression of mPPAR alpha protein and yet are viable and fertile and exhibit no detectable gross
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9. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.
The rat peroxisome-proliferator-activated receptor (PPAR) was expressed in insect cells and was shown to bind to a cognate PPAR response element (PPRE) from the acyl-CoA oxidase gene. Upon purification, PPAR was no longer able to bind DNA, although binding could be restored by addition of insect cell extracts. We investigated whether the retinoid X receptor
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10. Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression.
The ability of peroxisome proliferator-activated receptors (PPARs) to induce expression of a reporter gene linked to a peroxisome proliferator-responsive element (PPRE) from either the rat enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase gene or acyl-CoA oxidase [acyl-CoA:oxygen 2-oxidoreductase, EC 1.3.3.6] gene was examined by transient transfection ass
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11. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR
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12. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.
Previously, we identified a novel transcription factor, ARF6, as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. In order to identify the proteins which comprise the adipocyte ARF6 complex, we have purified this DNA binding activity from a cultured adipocyte cell line. We have developed a system for growth and differentiation of HIB-1B br