Ppads
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Participação do sistema purinérgico no locus coeruleus (LC) no controle cardiorrespiratório e térmico em normocapnia e hipercapnia em ratos não anestesiados
O LC é considerado uma região quimiossensível a CO2/pH em mamíferos e anfíbios, especificamente os neurônios noradrenérgicos. A neuromodulação purinérgica no LC desperta um interesse particular uma vez que a adenosina 5-trifosfato (ATP) atua como neuromodulador em várias áreas do tronco encefálico envolvidas na regulação cardiorrespiratória,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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2. Efeito do PPADS, antagonista do receptor P2, sobre a lesÃo cerebral, comportamento e memÃria de camundongos submetidos à isquemia cerebral focal permanente. / P2 receptors antagonist PPADS protects against neuronal damage, behavior and memory deficits induced by permanent focal brain ischemia.
ApÃs isquemia cerebral, o Trifosfato de Adenosina (ATP) atinge altas concentraÃÃes no espaÃo extracelular e pode atuar como agente tÃxico, que causa degeneraÃÃo celular e morte, mediada atravÃs de receptores P2X e P2Y. No presente estudo, foram investigados os efeitos do PPADS, um antagonista nÃo-seletivo dos receptores P2, sobre o comportamento e d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/01/2010
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3. Participação dos purinoceptores nas disfunções cardíacas e autonômicas em animais geneticamente hipertensos / Participation of purinoceptors on the cardiovascular and autonomic dysfunctions in genetically hypertensive animals
O presente estudo investigou em ratos geneticamente hipertensos (SHR) a participação dos purinoceptores P1 e P2 nas disfunções cardíacas e autonômicas na HAS, por métodos farmacológicos (efeito de agonistas e antagonistas seletivos), de biologia molecular (RT-PCR) e eletrofisiológicos (amperometria de vesícula única). Os resultados deste estudo mo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/05/2009
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4. Antidipsogenic effects of central adenosine-5'-triphosphate
Besides other physiological functions, adenosine-5'-triphosphate (ATP) is also a neurotransmitter that acts on purinergic receptors. In spite of the presence of purinergic receptors in forebrain areas involved with fluid-electrolyte balance, the effect of ATP on water intake has not been investigated. Therefore, we studied the effects of intracerebroventricu
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
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5. Novas abordagens a promoção das pequenas empresas
Muitos estudos evidenciam o papel do ATP no processo de desencadeamento da dor por agir em receptores P2X expressos nos terminais nervosos aferentes nociceptivos. Para investigar se esses receptores exercem uma função na dor da ATM, estudamos a presença de receptores P2X funcionais na ATM de ratos, examinando as conseqüências comportamentais da administ
Publicado em: 2003
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6. Avaliação da presença de receptores purinergicos P2X funcionais na região da ATM de ratos e do papel do ATP endogeno na sensibilização dos nociceptores da ATM
Muitos estudos evidenciam o papel do ATP no processo de desencadeamento da dor por agir em receptores P2X expressos nos terminais nervosos aferentes nociceptivos. Para investigar se esses receptores exercem uma função na dor da ATM, estudamos a presença de receptores P2X funcionais na ATM de ratos, examinando as conseqüências comportamentais da administ
Publicado em: 2003
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7. Calcium handling and purinoceptor subtypes involved in ATP-induced contraction in rat small mesenteric arteries.
1. The relationship between the stimulation of ATP receptors, the increase in intracellular free calcium concentration ([Ca2+]i; measured using the fluorescent indicator fura-2), contraction and the subtypes of purinoceptors involved were investigated in the small mesenteric artery of the rat. 2. In normal physiological solution, ATP (0.001-3 mM) caused conc
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8. Paracrine purinergic signaling determines lung endothelial nitric oxide production
Although the vascular bed is a major source of nitric oxide (NO) production, factors regulating the production remain unclear. We considered the role played by paracrine signaling. Determinations by fluorescence microscopy in isolated, blood-perfused rat and mouse lungs revealed that a brief lung expansion enhanced cytosolic Ca2+ (Ca2+cyt) oscillations in al
American Physiological Society.
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9. P2 purinoceptor-mediated depolarization of rat supraoptic neurosecretory cells in vitro.
1. Intracellular recordings were obtained from supraoptic magnocellular neurosecretory cells (MNCs) in superfused explants of rat hypothalamus. Application of ATP and UTP, but not adenosine, produced TTX-insensitive depolarizations accompanied by increases of input conductance. 2. The P2X agonists alpha,beta-methylene ATP, beta,gamma-methylene ATP and 2-meth
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10. Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter
We recently found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES). Goals of our study were to characterize the neural mechanisms responsible for axial and transverse stretch-activated responses in the LES. LES pressure was monitored in anesthetized and artificially ventilated m
American Physiological Society.
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11. The mechanism of calcium channel facilitation in bovine chromaffin cells.
1. This study was planned to clarify the mechanism of Ca2+ channel facilitation by depolarizing prepulses given to voltage-clamped bovine chromaffin cells. The hypothesis for an autocrine modulation of such channels was tested by studying the effects of a soluble vesicle lysate (SVL) on whole-cell Ba2+ currents (IBa). 2. SVL was prepared from a bovine adrena
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12. P2X purinoceptors in cultured myenteric neurons of guinea-pig small intestine.
1. Fast excitatory postsynaptic currents (fEPSCs) and responses to exogenously applied purinoceptor agonists were studied in primary cultures of myenteric neurons from guinea-pig small intestine. Whole-cell and outside-out configurations of the patch clamp technique were used. Hexamethonium (100 microM) partly inhibited fEPSCs in 28% of neurons. Hexamethoniu