Porphobilinogen Synthase
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Relevancia de polimorfismos geneticos para concentrações sanguineas e plasmaticas de chumbo na gravidez / Prevalence of genetics polymorphisms to plasma and blood lead concentration in pregnant
Mulheres grávidas constituem um grupo de indivíduos particularmente mais susceptíveis aos efeitos tóxicos associados ao chumbo (Pb)[1]. O chumbo é um metal pesado que se acumula nos tecidos mineralizados. Possui um comportamento similar ao cálcio, o que explica sua toxicidade. Durante a gravidez, o remodelamento ósseo promove a migração do chumbo pa
Publicado em: 2009
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2. EFEITOS PROTETORES DO ZINCO SOBRE ALTERAÇÕES COMPORTAMENTAIS E BIOQUÍMICAS INDUZIDAS PELO MERCÚRIO EM RATOS JOVENS / PROTECTOR EFFECTS OF ZINC ON BEHAVIORAL AND BIOCHEMICAL CHANGES INDUCED BY MERCURY IN YOUNG RATS
O mercúrio é um elemento tóxico capaz de induzir alterações bioquímicas, neurológicas e comportamentais que podem persistir por muito tempo após a exposição ao metal. A contaminação por mercúrio continua sendo um sério problema de saúde pública em países subdesenvolvidos e em desenvolvimento, onde existem garimpos para extração de ouro. N�
Publicado em: 2009
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3. ACTIVITIES OF ACETILCHOLINESTERASE AND PORPHOBILINOGENSYNTHASE AND BEHAVIORAL ALTERATION OF RATS EXPOSED TO NICOTINE / ATIVIDADE DA ACETILCOLINSTERASE E DA PORFOBILINOGÊNIO-SINTASE E ALTERAÇÃO COMPORTAMENTAL DE RATOS EXPOSTOS À NICOTINA
Tobacco smoking and nicotine replacement therapy are the main form of nicotine exposure. The drug abuse for humans often begins during adolescence and the exposure to nicotine during this phase produces long-term alterations, such as increase in cell replication and differentiation, and apoptosis. Some studies have reported that nicotine exerts important inh
Publicado em: 2007
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4. A novel 3-base deletion (IVS3+2_4delTGG) of the hydroxymethylbilane synthase gene in a Brazilian patient with acute intermittent porphyria
Acute intermittent porphyria (AIP, OMIM 176000) is an autosomal dominant metabolic disease caused by mutations in the gene encoding hydroxymethylbilane synthase (HMBS; EC 4.3.1.8; formely named porphobilinogen deaminase, PBGD), mapped to chromosome 11q23.3. We describe a novel mutation of the HMBS gene, a de novo 3-base deletion in the splicing donor site of
Genetics and Molecular Biology. Publicado em: 2007
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5. HEMATOLOGIC AND TOXICOLOGIC PARAMETERS IN BLOOD SAMPLES OF SMOKER DONATORS AND EFFECTS OF NICOTINE IN VITRO / PARÂMETROS HEMATOLÓGICOS E TOXICOLÓGICOS EM AMOSTRAS DE SANGUE DE DOADORES FUMANTES E EFEITOS DA NICOTINA in vitro
Os serviços de Hemoterapia no Brasil são regulados de acordo com a RDC- 153/2004. Em geral, os fumantes apresentam HT e níveis de Hb dentro dos valores de referência para a doação de sangue. Considerando que os valores de referência estão em uma faixa muito ampla, este trabalho estudou a qualidade do sangue utilizada para a doação em relação a al
Publicado em: 2006
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6. Oxygen-Mediated Regulation of Porphobilinogen Formation in Rhodobacter capsulatus
A Rhodobacter capsulatus hemC mutant has been isolated and used to show that oxygen regulates the intracellular levels of porphobilinogen. Experiments using a hemB-cat gene fusion demonstrated that oxygen does not transcriptionally regulate hemB transcription. Porphobilinogen synthase activity is not regulated by oxygen nor is the enzyme feedback inhibited b
American Society for Microbiology.
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7. Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer
BioMed Central.
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8. Levels of delta-aminolevulinate dehydratase, uroporphyrinogen-I synthase, and protoporphyrin IX in erythrocytes from anemic mutant mice.
Levels of erythrocyte delta-aminolevulinate dehydratase [ALA-dehydratase; porphobilinogen synthase; 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24], UROPORPHYRINOGEN-I synthase [Uro-synthase; porphobilinogen ammonia-lyase (polymerizing), EC 4.3;1.8], AND PROTOPORPHYRIN IX (Proto) were measured by sensitive semimicroassays
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9. Isolation and characterization of an aminolevulinate-requiring Rhodobacter capsulatus mutant.
Using transposon Tn5 mutagenesis, we isolated a mutant strain of Rhodobacter capsulatus that requires aminolevulinate for growth. Southern blot analysis indicated that this strain has a single Tn5 insertion. The addition of 0.1 mM aminolevulinate to the medium allowed the mutant to grow either aerobically or photosynthetically with generation times similar t
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10. On the enzymic defects in hereditary tyrosinemia.
The activity of the enzyme porphobilinogen synthase (EC 4.2.1.24) in erythrocytes from patients with hereditary tyrosinemia was less than 5% of that in a control group and the activity in liver tissue was less than 1% of the reported normal activity. Urine from patients with hereditary tyrosinemia contained an inhibitor that was isolated and identified as su
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11. Uroporphyrinogen I synthase induction in normal human bone marrow cultures: an early and quantitative response of erythroid differentiation.
Uroporphyrinogen I (URO) synthase [porphobilinogen ammonia-lyase (polymerizing), EC 4.3.1.8] activity increased when cultures of normal human bone marrow cells were incubated with erythropoietin. The increase of URO synthase activity was a linear function of erythropoietin concentration in the culture medium and was proportional to the extent of heme synthes
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12. Effect of chronologic age on induction of cystathionine synthase, uroporphyrinogen I synthase, and glucose-6-phosphate dehydrogenase activities in lymphocytes.
The activities of cystathionine synthase [L-serine hydro-lyase (adding homocysteine), EC 4.2.1.22], uroporphyrinogen I synthase [porphobilinogen ammonia-lyase (polymerizing), EC 4.3.1.8], and glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49) have been measured in phytohemagglutinin-stimulated lymphocytes of young a