Pomc
Mostrando 13-24 de 103 artigos, teses e dissertações.
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13. Administração central de citrato modula a homeostase periferica da glicose em ratos Wistar / Intracerebroventricular injection of citrate modulates feeding behavior and glucose uptake in epididymal fat pad and skeletal muscle rat
O hipotálamo desempenha importante papel na manutenção da homeostase da glicose. Robustos sinais originados pela leptina e insulina agem coordenando a ingestão alimentar, o gasto energético e o metabolismo periférico. No hipotálamo e nos tecidos periféricos, a AMPK é um sensor energético que regula o metabolismo celular através do controle entre a
Publicado em: 2007
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14. Effect of citrate on the hypothalamic AMPK, food intake and glucose homeostase / Efeito do citrato sobre a AMPK hipotalamica e o controle da fome e a homeostase da glicose
O aumento da prevalência da obesidade e diabete tipo 2 nas sociedades modernas está fortemente associado às doenças cardiovasculares, hipertensão, infarto e aterosclerose. Estas patologias têm sido relacionadas com ingestão calórica excessiva e diminuição do gasto energético. Muitos fatores regulam a ingestão alimentar, incluindo hormônios como
Publicado em: 2006
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15. Análise da expressão diferencial de genes do folículo ovariano de fêmeas pré-púberes e púberes Bos primigenius indicus (Nelore) por meio da Análise Serial de Expressão Gênica (SAGE) / Analysis of differential gene expression of ovarian follicle from prepubertal and pubertal Bos primigenius indicus (Nelore) females by Serial Analysis of Gene Expression (SAGE)
Puberty is the stage where any mammal, male or female, becomes able to produce viable gametes and manifest complete sexual behavior. These are results from the gradative adjustment between the increase in gonadotrophic activity and the ability of gonads in undergoing simultaneously both steroidogenesis and gametogenesis. One of the major factors interferring
Publicado em: 2005
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16. "Avaliação de regiões hipervariáveis de genes que predispõem à obesidade" / Evaluation of hypervariable regions from genes predisposing to obesity
The genetic variants LEP G-2548A, LEP 3HVR, D1S200 (LEPR), D18S858 (MC4R) D2S1788 (POMC) were studied in groups of 100 obese (GE) and 110 non-obese (GC) white individuals. Genotyping were carried out by PCR and RFLP techniques. Alleles frequencies from LEP -2548G and Class I alleles from LEP 3HVR were higher in GE group, when compared to GC group (P<0,05). T
Publicado em: 2004
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17. Controle neuroendócrino do peso corporal: implicações na gênese da obesidade
O peso corporal é regulado por uma interação complexa entre hormônios e neuropeptídeos, sob o controle principal de núcleos hipotalâmicos. Mutações nos genes de hormônios e neuropeptídeos, de seus receptores ou de elementos regulatórios, têm sido descritas na espécie humana, mas são tidas como raras, não explicando as formas mais comuns de ob
Arquivos Brasileiros de Endocrinologia & Metabologia. Publicado em: 2003-08
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18. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36
Inactivating mutations of the pro-opiomelanocortin (POMC) gene in both mice and humans leads to hyperphagia and obesity. To further examine the mechanisms whereby POMC-deficiency leads to disordered energy homeostasis, we have generated mice lacking all POMC-derived peptides. Consistent with a previously reported model, Pomc-/- mice were obese and hyperphagi
National Academy of Sciences.
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19. Expression of pro-opiomelanocortin-like gene in the testis and epididymis.
Adrenocorticotropin (ACTH), beta-endorphin, and the melanocyte-stimulating hormones (MSHs), which are products of a common precursor, pro-opiomelanocortin (POMC), are present in a variety of tissues other than pituitary. The recent detection of immunoreactive POMC-derived peptides in the male reproductive tract raised the possibility that these hormones migh
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20. Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.
Glucocorticoid hormones alter transcription of specific genes. Glucocorticoid-stimulated genes have been especially useful in unraveling molecular events responsible for positive gene regulation in mammals. The gene encoding proopiomelanocortin (POMC), which is under feedback inhibition by glucocorticoids, provides a model system to study negative gene regul
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21. Expression of the proopiomelanocortin gene is developmentally regulated and affected by germ cells in the male mouse reproductive system.
Proopiomelanocortin (POMC), a major pituitary product, is also present in the adult mouse testis. We have shown previously that POMC mRNAs are most abundant in a subpopulation of Leydig cells associated with tubules in specific stages of the cycle of the seminiferous epithelium. In the present study, we examined the expression of the gene encoding POMC durin
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22. Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice.
The product of a single gene encoding proopiomelanocortin (POMC) is differentially processed to produce corticotropin and alpha-melanotropin in anterior and intermediate pituitary cells, respectively. Hormonal control of POMC gene transcription and of corticotropin or alpha-melanotropin release is also tissue-specific; for example, glucocorticoids specifical
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23. Tissue-specific activity of the pro-opiomelanocortin gene promoter.
The pro-opiomelanocortin (POMC) gene is specifically expressed in corticotroph cells of the anterior pituitary. To define the POMC promoter sequences responsible for tissue-specific expression, we assessed POMC promoter activity by gene transfer into POMC-expressing pituitary tumor cells (AtT-20) and fibroblast L cells. The rat POMC promoter was only efficie
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24. Effects of corticotropin-releasing hormone and dexamethasone on proopiomelanocortin messenger RNA level in human corticotroph adenoma cells in vitro.
The effects of corticotropin-releasing hormone (CRH) and dexamethasone on proopiomelanocortin (POMC) mRNA levels in cultured pituitary adenoma cells were studied in 10 patients with Cushing's disease. As a control, POMC mRNA levels in cells from nonadenomatous tissues were examined in four patients. Human POMC mRNA in the cells was analyzed by Northern blot