Polyketides
Mostrando 1-12 de 66 artigos, teses e dissertações.
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1. Anti-Hyperglycemic Activities, Molecular Docking and Structure-Activity Relationships (SARs) Studies of Endiandric Acids and Kingianins from Endiandra kingiana
Diabetes has become a severe chronic disease worldwide with patients significantly increasing daily. Due to the side effects of insulin and oral hypoglycaemic agents employed in diabetes treatment, scientists are working hard to develop alternative approaches from natural plants that inhibit α-amylase and α-glucosidase. Consequently, by performing a phytoc
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis
The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture wa
J. Braz. Chem. Soc.. Publicado em: 2020-02
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3. Central nervous system and analgesic profiles of Lippia genus
Abstract Many people use medicinal plants to relieve disorders related to the central nervous system, such as depression, epilepsy, anxiety and pain, even though the effectiveness of most of them has not yet been proven through scientific studies. Plants of the Lippia genus, Verbenaceae, are widely used in ethnobotany as a food, for seasoning and in antisept
Rev. bras. farmacogn.. Publicado em: 2019-02
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4. AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS
Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzy
Quím. Nova. Publicado em: 2019-01
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5. Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi
The continuous search for biologically active compound candidates pushes the pursuit of new substances produced by diverse organisms. Endophytic fungi are known as a promising source of metabolites with several biological activities. Based on the rich Amazonian biodiversity and the chemical potential of microbial sources, three Talaromyces strains, all major
J. Braz. Chem. Soc.. Publicado em: 2018-03
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6. An Insight Into the Intraspecific Variation of Biosynthetic Gene Clusters Between Strains of Burkholderia thailandensis spp.
The present study aimed to investigate the intraspecific variation of biosynthetic gene clusters (BGCs) in different strains of Burkholderia thailandensis in order to guide natural products (NPs) discovery process. Species from the genus Burkholderia are emerging as promising species due to their biosynthetic potential. Through genome-mining strategies, it w
J. Braz. Chem. Soc.. Publicado em: 2016-08
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7. Amphidinolide P from the Brazilian octocoral Stragulum bicolor
Abstract Dinoflagellates are an important source of unique bioactive secondary metabolites. Symbiotic species, commonly named zooxanthellae, transfer most of their photosynthetically fixed carbon to their host. The mutualistic relationship provides the organic metabolites used for energy production but there are very few reports of the role of the dinoflagel
Rev. bras. farmacogn.. Publicado em: 2015-12
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8. CONSTITUINTES QUÍMICOS E ATIVIDADE FITOTÓXICA DAS FOLHAS DE
Annona nutans The phytochemical investigation and evaluation of the phytotoxic effect of the extract and fractions obtained from the leaves of
Annona nutans (R. E. Fr.) R. E. Fr. were performed. Phytotoxic activity was assessed on radicle and hypocotyl ofAllium cepa andLactuca sativa , where chloroform and ethyl acetatQuím. Nova. Publicado em: 2015-06
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9. TRIAGEM METABÓLICA POR PKS E NRPS EM ACTINOBACTÉRIAS ENDOFÍTICAS DE Citrus reticulata
Polyketides and non-ribosomal peptides are natural products widely found in bacteria, fungi and plants. The biological activities associated with these metabolites have attracted special attention in biopharmaceutical studies. Polyketide synthases act similarly to fatty acids synthetases and the whole multi-enzymatic set coordinating precursor and extending
Quím. Nova. Publicado em: 2015-03
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10. Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics
The discovery of secondary metabolites produced by microorganisms (e.g., penicillin in 1928) and the beginning of their industrial application (1940) opened new doors to what has been the main medication source for the treatment of infectious diseases and tumors. In fact, approximately 80 years after the discovery of the first antibiotic compound, and despit
Braz. J. Microbiol.. Publicado em: 2013-12
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11. Active polyketides isolated from Penicillium herquei
Neste trabalho estamos relatando o isolamento por métodos clássicos de cromatografia de seis policetídeos de Penicillium herquei. Os compostos citreoseine ( 1) , emodina ( 2) , janthinona ( 3) , citrinina ( 4) , citrinina H1( 5) e dicitrinol ( 6) foram identificados por métodos espectrais de RMN 1D e 2D e EM. Os compostos 1, 2 e 3 foram testados contra f
An. Acad. Bras. Ciênc.. Publicado em: 20/08/2013
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12. Formal synthesis of the biciclic polyketides saliniketals A and B / Síntese formal dos policetídeos bicíclicos salinecetais A e B
Os salinecetais A e B foram isolados em 2007 por Fenical e colaboradores a partir da actinobactéria marinha Salinispora arenicola, e mostraram ser importantes alvos na quimioprevenção do câncer como inibidores da ornitina descarboxilase. Concluímos a síntese do fragmento avançado C-4/C-17 (19) envolvendo 19 etapas em 5,5% de rendimento global a partir
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012