Pols
Mostrando 1-12 de 23 artigos, teses e dissertações.
-
1. Relações com investidores e assimetria informacional
RESUMO Empresas investem volumes significativos de recursos em departamentos de relações com investidores (RI). Os profissionais atuantes no departamento de RI são responsáveis pela comunicação da empresa com o mercado, de modo que a informação gerada seja amplamente difundida e entendida pelos investidores. Nesse contexto, esta pesquisa tem por obje
Rev. contab. finanç.. Publicado em: 27/03/2017
-
2. Uma análise da influência de fatores sistemáticos nos retornos das ações do mercado brasileiro / A systematic factors influence analysis on brazilian market stocks returns
Este estudo tem por objetivo examinar a existência de fatores macroeconômicos e fatores financeiros que expliquem os retornos de ações negociadas na Bolsa de Valores Brasileira (BM&FBovespa) durante o período analisado de Janeiro de 1996 a Dezembro de 2009. Além do excesso de retorno de mercado, são analisados os fatores variação da produção indus
Publicado em: 2010
-
3. Funções da proteína Pso9/Mec3 no controle do ciclo celular e reparação de DNA em Saccharomyces cerevisiae
A manutenção da estabilidade do material hereditário das células requer fidelidade na replicação do DNA, precisão na segregação dos cromossomos e a capacidade de evitar mutações herdáveis, causadas por injúrias espontâneas e induzidas no genoma. Para enfrentar estes desafios, as células possuem processos evolutivamente conservados, incluindo r
Publicado em: 2007
-
4. Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants
Resveratrol, a natural compound found in many dietary plants and in red wine, plays an important role in the prevention of many human pathological processes, including inflammation, atherosclerosis and carcinogenesis. We have shown that the antiproliferative activity of resveratrol correlated with its ability to inhibit the replicative pols (DNA polymerases)
Portland Press Ltd..
-
5. A Single Domain in Human DNA Polymerase ι Mediates Interaction with PCNA: Implications for Translesion DNA Synthesis
DNA polymerases (Pols) of the Y family rescue stalled replication forks by promoting replication through DNA lesions. Humans have four Y family Pols, η, ι, κ, and Rev1, of which Pols η, ι, and κ have been shown to physically interact with proliferating cell nuclear antigen (PCNA) and be functionally stimulated by it. However, in sharp contrast to the l
American Society for Microbiology.
-
6. Distinct mechanisms of cis-syn thymine dimer bypass by Dpo4 and DNA polymerase η
UV-light-induced cyclobutane pyrimidine dimers (CPDs) present a severe block to synthesis by replicative DNA polymerases (Pols), whereas Polη promotes proficient and error-free replication through CPDs. Although the archael Dpo4, which, like Polη, belongs to the Y family of DNA Pols, can also replicate through a CPD, it is much less efficient than Polη. T
National Academy of Sciences.
-
7. Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.
The ability of DNA polymerases (pols) to catalyze the template-directed synthesis of duplex oligonucleotides containing a nonstandard Watson-Crick base pair between a nucleotide bearing a 5-(2,4-diaminopyrimidine) heterocycle (d kappa) and a nucleotide bearing either deoxyxanthosine (dX) or N1-methyloxoformycin B (pi) has been investigated. The kappa-X and k
-
8. Effects of Exonuclease Activity and Nucleotide Selectivity of the Herpes Simplex Virus DNA Polymerase on the Fidelity of DNA Replication In Vivo
A mutagenesis system was developed for the in vivo study of the fidelity of DNA replication mediated by wild-type herpes simplex virus type 1 (HSV-1) strain KOS and its polymerase (Pol) mutant derivatives PAAr5, Y7, and YD12. The pHOS1 shuttle plasmid, which contained the SupF mutagenesis marker gene and the HSV oris sequence, was used for analysis of the mu
American Society for Microbiology.
-
9. DNA Polymerases of Low-GC Gram-Positive Eubacteria: Identification of the Replication-Specific Enzyme Encoded by dnaE
dnaE, the gene encoding one of the two replication-specific DNA polymerases (Pols) of low-GC-content gram-positive bacteria (E. Dervyn et al., Science 294:1716-1719, 2001; R. Inoue et al., Mol. Genet. Genomics 266:564-571, 2001), was cloned from Bacillus subtilis, a model low-GC gram-positive organism. The gene was overexpressed in Escherichia coli. The puri
American Society for Microbiology.
-
10. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation
High affinity antibodies are generated in mice and humans by means of somatic hypermutation (SHM) of variable (V) regions of Ig genes. Mutations with rates of 10−5–10−3 per base pair per generation, about 106-fold above normal, are targeted primarily at V-region hot spots by unknown mechanisms. We have measured mRNA expression of DNA polymerases ι, η
The National Academy of Sciences.
-
11. The Block of DNA Polymerase δ Strand Displacement Activity by an Abasic Site Can Be Rescued by the Concerted Action of DNA Polymerase β and Flap Endonuclease 1S⃞
Abasic (AP) sites are very frequent and dangerous DNA lesions. Their ability to block the advancement of a replication fork has been always viewed as a consequence of their inhibitory effect on the DNA synthetic activity of replicative DNA polymerases (DNA pols). Here we show that AP sites can also affect the strand displacement activity of the lagging s
American Society for Biochemistry and Molecular Biology.
-
12. Repression of Ribosome and tRNA Synthesis in Secretion-Defective Cells Is Signaled by a Novel Branch of the Cell Integrity Pathway
The transcription of ribosomal DNA, ribosomal protein (RP) genes, and 5S and tRNA genes by RNA polymerases (Pols) I, II, and III, respectively, is rapidly and coordinately repressed upon interruption of the secretory pathway in Saccharomyces cerevisiae. We find that repression of ribosome and tRNA synthesis in secretion-defective cells involves activation of
American Society for Microbiology.