Pluripotent Cells
Mostrando 13-24 de 222 artigos, teses e dissertações.
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13. VP22 herpes simplex virus protein can transduce proteins into stem cells
The type I herpes simplex virus VP22 tegument protein is abundant and well known for its ability to translocate proteins from one cell to the other. In spite of some reports questioning its ability to translocate proteins by attributing the results observed to fixation artifacts or simple attachment to the cell membrane, VP22 has been used to deliver several
Braz J Med Biol Res. Publicado em: 01/02/2013
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14. Biotechnological approaches to the treatment of aspermatogenic men
Aspermatogenesis is a severe impairment of spermatogenesis in which germ cells are completely lacking or present in an immature form, which results in sterility in approximately 25% of patients. Because assisted reproduction techniques require mature germ cells, biotechnology is a valuable tool for rescuing fertility while maintaining biological fatherhood.
Clinics. Publicado em: 2013
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15. Reprogramação de células mesenquimais de tecido adiposo em células-tronco pluripotentes por meio de proteína de fusão TAT / Nuclear reprogramming of adipose-tissue mesenchymal stem cells into pluripotent stem cells using TAT fusion protein
Os vírus são eficazes na transferência de genes em células devido aos seus mecanismos especializados. No entanto, vírus como veículos de entrega de genes podem acarretar em problemas, particularmente quando proposto para reprogramar células somáticas em células-tronco pluripotentes induzidas (iPS) visando utilização terapêutica. No presente estud
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2012
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16. The gene expression profiles of induced pluripotent stem cells (iPSCs) generated by a non-integrating method are more similar to embryonic stem cells than those of iPSCs generated by an integrating method
Induced pluripotent stem cells (iPSCs) obtained by the ectopic expression of defined transcription factors have tremendous promise and therapeutic potential for regenerative medicine. Many studies have highlighted important differences between iPSCs and embryonic stem cells (ESCs). In this work, we used meta-analysis to compare the global transcriptional pro
Genetics and Molecular Biology. Publicado em: 26/07/2012
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17. Identificação de genes e vias associadas aos transtornos do espectro autista / Identification of genes and pathways associated to autism spectrum disorders
Os transtornos do espectro autista (TEA) são um grupo de doenças neuropsiquiátricas caracterizadas por um prejuízo na capacidade de comunicação e de interação social e por padrões comportamentais estereotipados. Os TEA são geneticamente heterogêneos o que dificulta a identificação das alterações genéticas que estão contribuindo para estes tr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2011
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18. O uso de células-tronco adultas em modelos experimentais de crises convulsivas. / The use of adult stem cells in experimental models of seizures.
In Brazil, it is estimated that epilepsy affects from 2% of the population, about three million people at different ages and social classes. The use of antiepileptic drugs is the most common form of seizure control, although about 50- 70% of patients with epilepsy are refractory to medication. Because of difficulties in finding effective treatments, it is cr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/05/2010
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19. Mouse embryonic stem cells: the establishment of the system to produce differentiated cell types in vitro
During the last few years, embryonic stem (ES) cells have been a new tool in cell biology which is very promising for the scientific community to develop new cell therapies. ES cells are the only cell type that can differentiate into derivates of the three primary germ layers, not only in vivo but also, and most important, in vitro. This so-called pluripoten
Publicado em: 2010
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20. Desenvolvimento embrionário em búfalos (Bubalus bubalis Linnaeus, 1758) / The development of buffalo (Bubalus bubalis Linnaeus, 1758). embryos
No intuito de descrever a evolução do desenvolvimento do concepto bubalino entre 10 e 60 dias de gestação, esse estudo utilizou a metodologia de mensuração por Crow rump para revelar a idade estimada de 96 embriões e fetos coletados no Matadouro municipal de Macapá, no estado do Amapá entre os anos de 2006 a 2008. Os parâmetros utilizados consistir
Publicado em: 2009
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21. Uso de matriz extracelular (Matrigel®) para estabelecimento de cultivo de células-tronco embrionárias de suínos e caracterização da expressão de moléculas associadas à pluripotência / Use of extracellular matrix (Matrigel®) for establishment of porcine embryonic stem cells and expression characterization of plurpotency related molecules
Establishment of embryonic stem cell (ESC) culture in pigs has not been achieved. Verification of pluripotency markers and differentiation in the three embryonic layers are necessary for validation of a pluripotent cell line. The objective of this study was to establish and characterize porcine ESC culture using Matrigel and compare the expression of pluripo
Publicado em: 2008
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22. The effect of tyrosine-kinase inhibitors on the apoptosis machinery in chronic myeloid leukemia / Efeitos dos inibidores de tirosina-quinase sobre a maquinaria apoptótica na leucemia mielóide crônica
Chronic myeloid leukemia (CML) is a myeloproliferative disease resultant of a clonal expansion of pluripotent hematopoietic stem cells. The CML physiopathology is associated with a translocation between chromosomes 9 and 22 long arms, promoting the formation of a bcr-abl neogene, which codifies the Bcr-Abl protein. The Bcr-Abl oncoprotein presents tyrosine-k
Publicado em: 2007
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23. Canine osteosarcoma: a study on hystopathology, immunohistochemistry and proliferative activity / Osteossarcoma canino : estudo histopatologico, imunoistoquimico e da atividade proliferativa
Osteosarcoma is the most common of all malignant canine bone tumors and has a high aggressiveness potential. From the histological point of view it is a tumor with a heterogeneous cell pattern that is characterized by the production of bone matrix and/or immature bone by osteoblasts. Systematic studies with a clear objective to evaluate histogenetic aspects
Publicado em: 2007
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24. Nitric oxide: a major determinant of mast cell phenotype and function
Mast cells (MC) are important in the numerous physiological processes of homeostasis and disease. Most notably, MC are critical effectors in the development and exacerbation of allergic disorders. Nitric oxide (NO) is a diatomic radical produced by nitric oxide synthase (NOS), and has pluripotent cell signaling and cytotoxic properties. NO can influence many
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03