Plp A Gene
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. A two-year follow-up of asfotase alfa replacement in a patient with hypophosphatasia: clinical, biochemical, and radiological evaluation
SUMMARY Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benef
Arch. Endocrinol. Metab.. Publicado em: 2020-10
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2. Treatment of insomnia with repetitive transcranial magnetic stimulation (rTMS) in a patient with posttraumatic stress disorder (PTSD)
SUMMARY Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benef
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2020-10
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3. Caracterização de rearranjos cromossômicos aparentemente equilibrados associados a quadros clínicos / Characterization of apparently balanced chromosomal rearrangements associated with clinical phenotypes
Este estudo teve como objetivo identificar mecanismos pelos quais rearranjos cromossômicos aparentemente equilibrados possam estar associados de maneira causal a determinados quadros clínicos. Para isso estudamos seis translocações cromossômicas aparentemente equilibradas, detectadas em pacientes com malformações congênitas, comprometimento neuropsic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/10/2011
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4. Determinação da porcentagem de espermatozóides portadores de cromossomos X e Y no sêmen sexado mediante PCR em tempo real / Determination of the proportion of X- and Y- bearing spermatozoa in bovine sexed semen by real time PCR
There are different biotechnologies to apply to increase the animal production nowadays, reproduction techniques are including. The artificial insemination (AI), for example, is a technique very used during many years ago and it is used at extensive production. The aim of this technique is to increase the numbers of pregnancies with just one ejaculation what
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/09/2011
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5. Efeito da hipóxia e das deleções dos genes IL15 e PLP-A na vascularização do útero gestante mediada pelas células uNK / Effect of hypoxia and depletion of IL15 and PLP-A genes in the vasculature of pregnant uterus mediated by uNK cells
Um processo de remodelação progressiva da vascularização uterina precede a placentação em humanos e roedores para prover o suprimento sanguíneo adequado na interface materno-fetal, tendo as células NK um papel modulador através da produção de citocinas como o IFN gama , fatores de crescimento como o VEGF e radicais livres como o óxido nítrico (N
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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6. Produção e purificação de anticorpos específicos contra Staphylococcus aureus resistente à meticilina produzidos em eqüinos imunizados com uma vacina de DNA
Staphylococcus aureus resistente à meticilina (SARM) é um dos principais patógenos responsáveis pela infecção nosocomial e recentemente tem sido isolada fora do ambiente hospitalar, trazendo uma grande preocupação a médicos e pesquisadores. Esta resistência à meticilina é devida à presença do gene mecA, o qual codifica a PLP2a, uma proteína li
Publicado em: 2008
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7. Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.
Proteolipid protein (PLP) is the major myelin membrane protein of the central nervous system. We have isolated a copy of an alternatively spliced PLP gene transcript from a mouse brain cDNA library that was screened for PLP-related sequences. The encoded 241-amino acid protein differs from PLP by an internal deletion of 35-amino acid residues (116-150) from
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8. Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.
cDNA clones encoding proteolipid protein (PLP) were isolated from a mouse brain library and sequenced. We describe two transcripts arising from the PLP locus by alternative splicing: the major one encodes the 277-amino acid PLP protein and the minor one corresponds to the DM-20 protein, a PLP-like protein of 20,000 Mr that shares both amino and carboxyl regi
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9. Expression of Murine Coronavirus Recombinant Papain-Like Proteinase: Efficient Cleavage Is Dependent on the Lengths of both the Substrate and the Proteinase Polypeptides
Proteolytic processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral replication. In MHV strain A59 (MHV-A59), the replicase gene encodes two predicted papain-like proteinase (PLP) domains, PLP-1 and PLP-2. Previous work using viral polypeptide substrates synthesized by in vitro transcription and translation from the rep
American Society for Microbiology.
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10. Individual exons encode the integral membrane domains of human myelin proteolipid protein.
The gene encoding human proteolipid protein (PLP) was isolated from a human genomic library by hybridization with labeled DNA of a PLP-specific cDNA clone. The entire PLP gene spans approximately 17 kilobases. Restriction and sequence analysis revealed seven exons and six introns. The entire nucleotide sequences of the exons and of the exon-intron transition
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11. Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein.
Mutations in genes encoding membrane proteins have been associated with cell death of unknown cause from invertebrate development to human degenerative diseases. A point mutation in the gene for myelin proteolipid protein (PLP) underlies oligodendrocyte death and dysmyelination in jimpy mice, an accurate model for Pelizaeus-Merzbacher disease. To distinguish
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12. Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion.
We have examined the expression and secretion of endogenous parathyroid hormone-like peptide (PLP) in primary cultures of normal human keratinocytes. In response to growth factors and fetal bovine serum, PLP mRNA expression and immunoreactive PLP release into conditioned medium was rapidly increased (within hours) whereas these effects were inhibited by 1,25