Pldla
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. In vitro and in vivo cell tracking of PKH26-labeled osteoblasts cultured on PLDLA scaffolds
Abstract The importance of monitoring in vivo interaction that occurs between cells /bio/tissue recipient in the understanding of tissue regeneration processes becomes ever greater. This study aims to monitor and evaluate the influence of scaffold implants of poly (L-co-D, L lactic acid) - PLDLA synthesized in the laboratory, previously cultured with primary
Polímeros. Publicado em: 2017-03
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2. Avaliação do desempenho in vivo de pinos porosos de hidrogel para preenchimento de defeito osteocondral em coelhos
RESUMO OBJETIVO: Trabalho experimental para avaliar o desempenho biológico de arcabouços de hidrogel poli (L-co-D, L ácido lático)-co-trimetileno carbonato/poli (álcool vinílico) (PLDLA-co-TMC/PVA) como implante no preenchimento, e não no reparo, de defeito osteocondral em coelhos Nova Zelândia e verificar a influência do material na proteção te
Rev. bras. ortop.. Publicado em: 2017-02
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3. Caracterização de pinos da blenda poli(L-co-D,L ácido láctico)/poli(caprolactona triol) (PLDLA/PCL-T) e análise das propriedade mecânicas dos pinos durante degradação in vitro
Resumo Os dispositivos de fixação óssea, metálicos convencionais, usados em cirurgia crâniomaxilofacial têm apresentado alguns problemas, tais como, corrosão, inflamação e infecção, além de neoformação de estrutura óssea mecanicamente inferior devido à atrofia gerada pela diferença de módulo elástico entre metal e osso, razões que têm le
Polímeros. Publicado em: 16/06/2016
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4. Biological Evaluation of PLDLA Polymer Synthesized as Construct on Bone Tissue Engineering Application
In bone tissue engineering, cell-scaffold constructs are used to stimulate complete, functional tissue replacement that does not occur naturally in critical-size defects. In this report, we describe the application potential of poly (L-co-D,L lactic acid)-PLDLA 70/30, synthesized in house as constructs loaded with osteoblast-like cells on bone tissue enginee
Mat. Res.. Publicado em: 23/02/2016
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5. Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds
Surface modification techniques based on the grafting of chemical functional groups and immobilization of bioactive molecules have been used to improve biocompatibility and clinical performance of bioabsorbable scaffolds in tissue engineering and medicine regenerative applications. This study aimed at developing and characterizing a biomimetic surface to sti
Mat. Res.. Publicado em: 2014-12
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6. Membrana de PLDLA-TMC como protetor na regeneração do tendão calcâneo: Estudo in vivo em coelhos
Um dos maiores problemas da cirurgia restauradora dos tendões flexores é evitar a formação de aderências, pois limita seu deslizamento. Assim, é muito desejável que a cicatrização ocorra o mais rápido possível, restaurando a capacidade de deslizamento dos tendões, sem limitações dos movimentos. O objetivo deste trabalho foi analisar a resistên
Polímeros. Publicado em: 27/05/2014
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7. Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate
Terpolymers of L-lactide, D,L-lactide and trimethylene carbonate (TMC) were synthesized via the ring-opening polymerization reaction for cyclic monomers using stannous octoate as the initiator at a ratio of ~0.05 mol% (monomers/(SnOct)2). Synthesis was done at 130 ºC for 48 h. The inclusion of TMC, an aliphatic elastomeric polycarbonate, alongside polymer c
Mat. Res.. Publicado em: 27/05/2014
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8. Preparation and characterization of paclitaxel-loaded PLDLA microspheres
Paclitaxel (Taxol®), is a drug used to treat ovarian, breast, lung and bladder cancer. However, the low solubility of this drug in water is a major limitation in its clinical use. One strategy to overcome this limitation would be to encapsulate paclitaxel in polymeric microspheres that are biocompatible and can be used as drug carriers. The aim of this stud
Mat. Res.. Publicado em: 18/03/2014
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9. In vitro degradation of poly (L-co-D,L lactic acid) containing PCL-T
The application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PCL-T) on the degeneration process in the copolymer poly(L-co-
Polímeros. Publicado em: 2014
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10. Lithograph-moulded poly-L-co-D,L lactide porous membranes for osteoblastic culture
Pore size, shape, wall morphology, porosity, and interconnectivity are important characteristics of the scaffolds. Lithography is a manufacturing technique that allows the production of tridimensional scaffolds with a controllable and reproducible inner architecture. The aim of this study was to use lithography to create a poly-L-co-D,L lactide (PLDLA) scaff
Mat. Res.. Publicado em: 24/09/2013
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11. In vitro degradation of Poly-L-co-D, L-lactic acid membranes
Poly-L-co-D.L-lactic (PLDLA) is a bioresorbable polymer whose properties have been studied for degradation sensitivity and its application in medicine. In this study, the potential of PLDLA membranes for temporary implantation was evaluated. PLDLA membranes were prepared with the solvent evaporation technique and characterized by differential scanning calori
Mat. Res.. Publicado em: 13/11/2012
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12. The use of PLDLA/PCL-T scaffold to repair osteochondral defects in vivo
The physiological repair of osteochondral lesions requires the development of a scaffold that is compatible with the structure of the damaged tissue, cartilage and bone. The aim of this study was to evaluate the biological performance of a PLDLA/PCL-T (90/10) scaffold for repairing osteochondral defects in rabbits. Polymeric scaffolds containing saccharose (
Mat. Res.. Publicado em: 13/11/2012