Platinum Compound
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Synthesis and evaluation of platinum complexes with potential antitumor activity
Abstract A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cel
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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2. Irinotecan and oxaliplain : an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer
Colorectal cancer is one of the most frequent malignancies in humans and an important cause of cancer death. Metastatic colorectal cancer remains incurable with available systemic therapeutic options. The most active cytotoxic drug against this malignancy, the antimetabolite 5-fluorouracil, was developed more than forty years ago, and as a single agent produ
Publicado em: 2010
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3. SYNTHESIS AND CHARACTERIZATION OF COMPOUNDS FORMED BETWEEN CISPLATINUM AND GLUTATHIONE OR PENICILLAMINE LIGANDS / SÍNTESE E CARACTERIZAÇÃO DE COMPOSTOS FORMADOS ENTRE A CISPLATINA E OS LIGANTES GLUTATIONA OU PENICILAMINA
Cisplatinum is considered an important chemotherapeutic drug used against some kinds of cancer. However, the use of this drug may cause side effects such as ototoxicity, neurotoxicity and, mainly, nephrotoxicity. This fact has been related to the interaction of cisplatinum with biomolecules containing sulfur, such as proteins and amino acids. To promote the
Publicado em: 2010
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4. Investigação teórica da quimisssorção do ânion metanossulfonato em eletrodos de platina (111) e (100) via método semi-empírico
Several electrochemical processes, such as electrocatalysis of organic substrates, make use of mediators. One of the mediators is the most commonly used anion methanesulfonate, CH3SO3, which has several advantages for such use, and chemical stability considered one of them. However, experimental studies indicate the possibility of this compound suffer the ad
Publicado em: 2010
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5. Desenvolvimento de modelo experimental de neuropatia sensitiva perifÃrica induzida pelo agente antineoplÃsico oxaliplatina em camundongos. / Development of experimental model of peripheral sensitive neuropathy prompted by the oxaliplatin in mice.
Oxaliplatina (OXL) Ã a 3Â geraÃÃo de agentes platinos com amplo espectro de atividade antitumoral. Exibe potente atividade citotÃxica, incluindo cÃncer colorretal, ovariano e pulmonar. Dentre os efeitos tÃxicos estÃo: laringoespasmo, nÃuseas, vÃmitos, fadiga e neuropatia perifÃrica, foco desse trabalho. Essa pesquisa objetivou desenvolver um model
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2009
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6. Aqueous Congo Red degradation induced by plasma with glow discharge electrolysis / Degradação do corante Vermelho Congo em solução aquosa através de plasma obtido por eletrólise de alta tensão
Due to the concern with environmental impact and the need for the use of dyes for the textile industries, during the last years several studies has been undertaken to develop new technologies for energetic treatments that allow the degradation of compounds present in industrial waste. In this present work, the construction of a system for degradation of orga
Publicado em: 2009
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7. Determinação de Sn(II) por polarografia: aplicação no controle de qualidade de reagentes liofilizados para radiodiagnóstico / Polarographic determination of Sn(II): application in the quality control of radiopharmaceutical reagents
Stannous chloride (SnCl2.2H2O) is the major compound used for reduction of generator-derived 99mTc-pertechnetate in cold kits for on site preparation of 99mTc-radiopharmaceuticals. These cold kits usually contain a ligand, stannous chloride, and different additives. Various techniques were described for tin determination, but they cannot distinguish between
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/07/2008
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8. A Interação substrato-modificador e sua importância para a hidrogenação enantiosseletiva de alfa-cetoésteres
The heterogeneous asymmetric catalysis plays an important and crucial role in many chemical processes and has therefore become a growing and interesting field. The enantioselective hydrogenation of α-ketoesters is one of the best known examples of such process. Methyl pyruvate, which can be converted to (R)- and (S)-methyl lactate with an enantioselecti
Publicado em: 2004
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9. Estudo do comportamento eletroquimico de aminas biogenicas na presença de carboxilatos utilizando eletrodo de gota pendente de mercurio
The interest in the redox chemistry of biogenic amines, particularly dopamine (DA), is based on the fact that many of these compounds are directly involved in neurotransmission processes and, consequently, related to neurological disorders, like Parkinson and Alzheimer s diseases. The electrochemical determination of phenolic compounds using solid electrodes
Publicado em: 2003
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10. Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer
Colorectal cancer is one of the most frequent malignancies in humans and an important cause of cancer death. Metastatic colorectal cancer remains incurable with available systemic therapeutic options. The most active cytotoxic drug against this malignancy, the antimetabolite 5-fluorouracil, was developed more than forty years ago, and as a single agent produ
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-09
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11. Obtenção, caracterização e avaliação do desempenho catalitico de [alfa]-fosfatos de zirconio (IV) intercalados com Cu(II) ou Pt(II) na reação de HTS
The a-zirconium (IV) hydrogenphosphate, usually refereed as a-ZrP, is one of the most extensively studied members of the group 4 layered metal phosphates. This compound has received great attention in the last years due to it s intercalation, ionic condutivity, ion exchange and catalytic properties. From the catalytic point of view, the a-ZrP is particularly
Publicado em: 2001
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12. Preparação, caracterização e avaliação de catalisadores heterogeneos a base de Pt na hidrogenação enantiosseletiva do piruvato de metila em presença de cinconidina
Platinum based catalysts were prepared by impregnation on different supports, namely C, Al303, TiO2 and La203. The commercial activated carbon was oxidized by different methods in order to modify its surface. The main surface groups identified were carboxylic acid, when HN03 is the oxidizing agent, and carbonyl, phenol and quinone, when the oxidation is made
Publicado em: 2000