Platelets Refractoriness
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. The relevance of a bank with genotyped platelets donors
ABSTRACT Objective: Describe the clinical and laboratory characteristics and the transfusion strategy of patients at Hospital Israelita Albert Einstein with platelet refractoriness and identify their etiological characteristics. Standardize the platelet immunofluorescence technique by flow cytometry as a test for platelet compatibility in immune platelet re
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Platelet antibody detection by flow cytometry: an effective method to evaluate and give transfusional support in platelet refractoriness
BACKGROUND: Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies. Refractoriness can be diagnosed by laboratory tests and patients should receive compatible platelet transfusions. A fast, effective and low cost antibody-screening method which det
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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3. Avaliação de diferentes metodologias laboratoriais para detecção de aloanticorpos plaquetários. Determinação da prevalência e importância clínica destes aloanticorpos em pacientes transfundidos / Evaluation of different methodologies for platelet alloantibodies detection. Clinical impact and prevalence of platelet antibodies in transfused patients.
A aloimunização contra antígenos plaquetários é um dos grandes desafios no tratamento de pacientes refratários à transfusão de plaquetas. OBJETIVOS: avaliar o desempenho de metodologias mais utilizadas em laboratórios de referência internacional para a pesquisa de anticorpos plaquetários (PAP); verificar a prevalência destes anticorpos na nossa p
Publicado em: 2008
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4. Thrombin-Induced Platelet Secretion: FURTHER EVIDENCE FOR A SPECIFIC PATHWAY
We have studied the interaction between thrombin and washed, human platelets using prostacyclin, a reversible inhibitor of platelet secretion. The effect of thrombin is limited to those reactions that are not inhibited by an increased concentration of platelet cyclic adenosine 3′,5′-monophosphate, because prostacyclin is a potent inducer of the latter. P
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5. Treatment of aplastic anemia by marrow transplantation from HLA identical siblings. Prognostic factors associated with graft versus host disease and survival.
73 consecutive patients with severe aplastic anemia were treated by marrow transplantation from hematologically normal HLA identical siblings. 68 patients lived long enough to document marrow engraftment. 21 rejected the graft and 19 of these died. 47 sustained engraftment and 18 of these died. In 16 patients, death was associated with graft versus host dise
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6. Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor.
The kinetic changes induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) on hemopoietic cells were assessed in physiological conditions by administering GM-CSF (8 micrograms/kg per d) for 3 d to nine patients with solid tumors and normal bone marrow (BM), before chemotherapy. GM-CSF increased the number of circulating granulocytes and monocyt