Platelet Aggregation Inhibitors
Mostrando 1-12 de 48 artigos, teses e dissertações.
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1. Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom
Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/05/2013
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2. Purificação e caracterização biológica de uma nova serinoprotease com atividade trombina"like" do veneno total de Brothrops andianus (TLBan) / Purification and biological characterization of a new serine protease with thrombin "like" activity the whole venom of Brothrops andianus (TLBan)
In this word, a new serine protease with thrombin "like" activity the venom of Bothrops andianus (TLBan), snake of the Andes of Peru, was isolated by two steps: molecular exclusion chromatography G-75 and liquid chromatography in reversed-phase HPLC; with a high degree of purity and molecular homegenidade. Through of electrophoresis on SDS-PAGE shows the TLB
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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3. Análise proteômica das salivas dos triatomíneos Rhodnuis brethesi, Rhodnius robustus e Panstrongylus megistus, vetores da doença de Chagas
Triatomine bugs acting as vectors of Chagas‟ disease are haematophagous organisms in all of its evolvement phases. Their feeding success is greatly related to their salivary glands content. The presence of a pool of specific proteins allows this insect to access its food by counteracting host haemostatic mechanisms, such as platelet aggregation, clotti
Publicado em: 2009
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4. Mecanismo da incubação de enterotoxinas estafilococicas e do lipopolissacaride na agregação e na adesão de plaquetas humanas / Incubation effects of staphylococcal enterotoxins and lipopolysaccharide in human platelets aggregation and adhesion
Sepsis is the second major cause of death in intensive care unit. Septic patients show abnormalities in platelet like thrombocytopenia, prolongation in coagulation time, disseminated intravascular coagulation, deep venous thrombosis and bleedings. However, the mechanisms involved in these platelet alterations are not totally clear. The objective of this work
Publicado em: 2008
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5. Biochemical and biophysical studies of metalloproteinases/disintegrins from snake venom / Estudos bioquímicos e biofísicos de metaloproteinases/desintegrinas de venenos de serpentes
Metalloproteinases/disintegrin (MD) isolated from snake venom are potent inhibitors of platelet aggregation and cell adhesion, processes involved in illnesses as cancer and thrombosis. MD belong to the PIII class of the metalloproteinase/disintegrin gene family and they are constituted by three domains: the catalytic domain, metalloprotease; disintegrin-like
Publicado em: 2008
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6. "Fibrilação atrial e tratamento antitrombótico em pacientes atendidos em hospital especializado em cardiologia no Brasil" / Atrial fibrillation and antithrombotic treatment in a Brazilian heart hospital
Objetivo: Avaliar o uso de antitrombóticos em pacientes com fibrilação atrial (FA) em hospital cardiológico no Brasil (InCor).Métodos e resultados: Um estudo observacional transversal analisou os prontuários de todos os pacientes atendidos no InCor em cada um de 5 dias separados no ano de 2002 (Fase 1), sendo prospectivamente reanalisados após 1 ano (
Publicado em: 2005
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7. "Análise volumétrica da hiperplasia intimal intra-stent em pacientes diabéticos tratados com e sem abciximab" / Volumetric analysis of in-stent intimal hyperplasia in diabetic patients treated with or without abciximab
Ninety-six type 2 diabetics were randomly assigned to receive abciximab or no abciximab at the time of elective stent implantation to determine whether this IIb/IIIa glycoprotein inhibitor would reduce in-stent intimal hyperplasia, measured by intravascular ultrasound, at 6-month follow-up. Volumetric analysis showed that abciximab was not associated with a
Publicado em: 2004
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8. Estudo farmacológico da fração hexânica de Lonchocarpus sericeus (Poir) Kunth e seus constituintes químicos, lonchocarpina e derricina / Pharmacologic study of the hexane fraction from Lonchocarpus sericeus (Poir) Kunth and from their chemical constituents, lonchocarpin and derricin
O gênero Lonchocarpus é bastante conhecido e amplamente estudado, porém não há registros na literatura científica dos usos farmacológicos da espécie Lonchocarpus sericeus (Poir.) Kunth, (Leguminosae Papilionaceae). Estudos químicos demonstraram que a fração hexânica das cascas das raízes de L. sericeus (FLS) é rica nas chalconas: lonchocarpina
Publicado em: 2004
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9. Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke
Ischemic mechanisms in patients with brain and heart attacks have been studied for more than 150 years. Antiplatelets agents did show benefit in secondary prevention. Aspirin is the most common antiaggregant in clinical use today. However, the benefit produced by the "best" antiplatelet regimen in stroke prevention is lower than 40%. The adherence of circula
Arquivos de Neuro-Psiquiatria. Publicado em: 2000-03
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10. Estudo da trombose pulmonar causada pela peçonha da cascavel sul-americana (Crotalus durissus) e suas frações
Convulxin is a high molecular weight, non-enzymatic, platelet aggregating protein present in the venom of South American rattlesnake, Crotalus durissus terrificus. In this work, we investigatd the ability of convulxin to cause pulmonary thrombosis in mice after intravenous injection and examined the possible mechanism (s) involved using specific inhibitors.
Publicado em: 1999
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11. Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products.
Vascular endothelial injury associated with arterial narrowing leads to platelet adhesion and aggregation at the site of endothelial injury and to the local accumulation of several mediators that promote platelet aggregation and vasoconstriction, including thromboxane A2, serotonin, adenosine diphosphate, platelet activating factor, oxygen-derived free radic
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12. Effect of Heparin and Heparin Fractions on Platelet Aggregation
Porcine intestinal mucosal heparin induced aggregation of platelets in citrated platelet-rich plasma and enhanced platelet aggregation and serotonin secretion induced by other agents. This action of heparin was blocked by substances that elevate platelet cyclic AMP and by EDTA but not by inhibitors of platelet cyclooxygenase. The effect was not inhibited by