Plasma Thiols
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats
ABSTRACT Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Ther
Rev. bras. farmacogn.. Publicado em: 2018-01
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2. DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases
PURPOSE: To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency.METHODS: The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isoflurane and to a lesser degree to sevoflurane
Acta Cir. Bras.. Publicado em: 2014-04
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3. Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes
The aim of this study was to determine whether plasma levels of carbonylated proteins, total antioxidant capacity (TAC) and reduced protein thiols could be suitable biomarkers of risk factors for diabetic foot. Individuals with type 2 diabetes with normal protective sensation (normal foot group) vs. loss of protective sensation and/or signs of peripheral art
Braz. arch. biol. technol.. Publicado em: 19/11/2013
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4. Ischemic preconditioning reduces peripheral oxidative damage associated with brain ischemia in rats
Brain ischemia followed by reperfusion causes neuronal death related to oxidative damage. Furthermore, it has been reported that subjects suffering from ischemic cerebrovascular disorders exhibit changes in circulating platelet aggregation, a characteristic that might be important for their clinical outcome. In the present investigation we studied tert-butyl
Publicado em: 2010
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5. Oxidation of the albumin thiol to sulfenic acid and its implications in the intravascular compartment
Human serum albumin (HSA) is the most abundant protein in the intravascular compartment. It possesses a single thiol, Cys34, which constitutes ~80% of the total thiols in plasma. This thiol is able to scavenge plasma oxidants. A central intermediate in this potential antioxidant activity of human serum albumin is sulfenic acid (HSA-SOH). Work from our labora
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-04
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6. The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria
Malaria remains an important health problem in tropical countries like Brazil. Thrombocytopenia is the most common hematological disturbance seen in malarial infection. Oxidative stress (OS) has been implicated as a possible mediator of thrombocytopenia in patients with malaria. This study aimed to investigate the role of OS in the thrombocytopenia of Plasmo
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-09
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7. STUDY OF OXIDATIVE PROFILE AND ACETYLCHOLINESTERASE ACTIVITY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA. / ESTUDO DO PERFIL OXIDATIVO E ATIVIDADE DA ENZIMA ACETILCOLINESTERASE EM PACIENTES COM LEUCEMIA LINFOBLÁSTICA AGUDA (LLA)
Acute lymphoblastic leukemia (ALL) is the most common cancer found in the pediatric population and is characterized by uncontrolled proliferation and maturation arrest of lymphoid progenitor cells (lymphoblasts) in the bone marrow. In ALL occurs an increase in the production of reactive species and studies show the involvement of oxidative stress in ALL path
Publicado em: 2008
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8. Caracterização das reações do nitroprussiato de sodio com tiois e oxihemoglobina
Nitric oxide (NO) is a messenger molecule synthesized by mammals and plays a large number of biological roles, including the control of arterial pressure, neurotransmission and the inhibition of platelet aggregation. Sodium nitroprusside ([Na2[Fe (CN)5(NO)], SNP) is an NO donor metal complex used clinically for over 70 years in the control of hypertension cr
Publicado em: 2003
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9. Prevenção das disfunções vasculares no inicio da aterogenese : efeito da S-Nitroso-N-Acetilcisteina, SNAC, em camundongos knock out para o receptor da LDL
Pathophysiology of the NO/NO synthase system and endothelium dysfunctional changes in early phases of the atherogenic process are incompletely understood. In hypercholesterolemic LDLr-/- mice, we addressed changes in endothelium-dependent relaxations, NO synthase expression and plaque burden in the absence or presence of the nitrosothiol NO donor S-nitroso-N
Publicado em: 2003
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10. Effect of simvastatin, alpha-tocopherol and L-arginin on the endogenous nitric oxide synthase inhibitors, nitric oxide metabolites and thiols in hypercholesterolemic patients / Efeito da sinvastatina, alfa-tocoferol e L-arginina sobre os inibidores endógenos da óxido nítrico sintase, metabólitos do óxido nítrico e tióis em pacientes hipercolesterolêmicos
The aim of this study was to evaluate the effect of sinvastatin, isolated and associated to α-tocopherol and to L-arginine, on the endogenous inhibitors of nitric oxide synthase, on nitric oxide metabolytes and thiols, in hypercholesterolemic patients. A group of 16 hypercholesterolemic patients were analysed, acconting to the protocol: a washout period
Publicado em: 2002
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11. Oxygen free radicals and congestive heart failure.
Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols we
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12. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.
Plasma albumin reacts with nitric oxide (NO) to form the bioactive adduct, S-nitroso-albumin (S-NO-albumin). The limited intracellular access of S-NO-albumin suggests the need for a vascular transfer mechanism of NO from a large plasma S-NO-albumin pool to effect biologic function. To study the role of low molecular weight (LMW) thiols in NO transfer in vivo