Pk Pd Modeling
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Abordagem farmacocinética e farmacodinâmica no monitoramento terapêutico de antimicrobianos em pacientes queimados da unidade de terapia intensiva / Pharmacokinetic and pharmacodynamic approach for antimicrobial therapeutic monitoring in burn patients from the intensive care unit
Introdução: A sepse é a maior causa de morbidade e mortalidade em pacientes queimados, uma vez que profundas alterações ocorrem na farmacocinética de agentes antimicrobianos prescritos para o controle das infecções. Além disso, pacientes queimados podem apresentar quadro de infecção por germes da comunidade, numa fase precoce de internação na UT
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/03/2011
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2. Modelagem farmacocinética-farmacodinâmica da piperacilina em ratos imunodeprimidos infectados com Escherichia coli
Objetivos: Avaliar a adequabilidade do modelo farmacocinético-farmacodinâmico (PK-PD) (NOLTING et al., 1996b) para modelar o efeito bactericida da piperacilina (PIP) em ratos Wistar infectados experimentalmente com Escherichia coli ATCC 25922. Metodologia: Experimentos de Farmacocinética: Determinou-se as concentrações plasmáticas totais e livres tecid
Publicado em: 2008
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3. Morphine pharmacokinetic-pharmacodynamic modeling administered by patient controlled analgesia (PCA) pump in the postoperative period of myocardial revascularization surgery / Modelagem farmacocinética-farmacodinâmica da morfina administrada através de bomba controlada pelo paciente no pós-operatório de revascularização do miocárdio
Introduction: Morphine administration using patient controlled analgesia (PCA) for treatment of post surgical and traumatic pain has been a current practice in many hospitals. However, large or repeated doses of this opioid are associated to dose dependent adverse events, including, respiratory depression. Considering patients submitted to thoracic surgery,
Publicado em: 2008
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4. Modelagem farmacocinética-farmacodînâmica das fluorquinolonas levofloxacino e gatifloxacino / Pharmacokinetic-Pharmacodynamic modeling of the fluoroquinolones levofloxacin and gatifloxacin
Objetivo: O objetivo geral deste trabalho foi estabelecer modelo farmacocinéticofarmacodinâmico (modelo PK/PD) para descrever o perfil temporal do efeito bactericida do levofloxacino e do gatifloxacino contra Streptococcus pneumoniae. Método: Para alcançar este objetivo as seguintes etapas foram realizadas: i) foram validadas metodologias analíticas de
Publicado em: 2008
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5. Modelagem farmacocinética-farmacodinâmica do antifúngico voriconazol
Objetivos: O objetivo deste trabalho foi o desenvolvimento de um modelo farmacocinético/farmacodinâmico (PK/PD) para descrever o efeito antifúngico voriconazol (VRC) contra espécies de Candida. Método: Para alcançar este objetivo as seguintes etapas foram realizadas: i) foi adaptado e padronizado modelo de candidíase disseminada em ratos Wistar imunoc
Publicado em: 2008
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6. Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients
FTY720 is a new and effective immunosuppressive agent, which produces peripheral blood lymphopenia through a lymphocyte homing effect. We investigated the relationship between the dose of FTY720 or blood concentration (pharmacokinetics, PK) and peripheral lymphopenia (pharmacodynamics, PD) in 23 kidney transplant recipients randomized to receive FTY720 (0.25
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-05
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7. Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Norfloxacin in Rats
A previously developed pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of norfloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of norfloxacin at a rate of 5 mg kg of body weight−1 min−1 over 30 min. Blood samples w
American Society for Microbiology.
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8. Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data
Accurate predictions of human pharmacokinetic and pharmacodynamic (PK/PD) profiles are critical in early drug development, as safe, efficacious, and “developable” dosing regimens of promising compounds have to be identified. While advantages of successful integration of preclinical PK/PD data in the “anticipation” of human doses (AHD) have been recog
Springer US.
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9. Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Imipenem in Healthy Rats
A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was developed to investigate the epileptogenic activity of imipenem in rats. Initially, animals received an intravenous infusion of imipenem at a rate of 2.65 mg min−1 for 30 min. Blood samples were collected for drug assay, and an electroencephalogram (EEG) was recorded during infusion and postin
American Society for Microbiology.
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10. Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion.
We developed and applied pharmacokinetic-pharmacodynamic (PK-PD) models to characterize in vitro bacterial rate of killing as a function of ceftazidime concentrations over time. For PK-PD modeling, data obtained during continuous and intermittent infusion of ceftazidime in Pseudomonas aeruginosa killing experiments with an in vitro pharmacokinetic model were
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11. Pharmacodynamic modeling of the in vivo interaction between cefotaxime and ofloxacin by using serum ultrafiltrate inhibitory titers.
The pharmacokinetics (PK) and pharmacodynamics (PD) of cefotaxime and ofloxacin and of their combination were examined in a three-period randomized crossover study involving 12 healthy adults. The PK of cefotaxime and ofloxacin were modeled. PD was assessed from the predicted concentrations in serum and serum untrafiltrate inhibitory titers for 10 test organ
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12. Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions
Empirical Bayes (“post hoc”) estimates (EBEs) of ηs provide modelers with diagnostics: the EBEs themselves, individual prediction (IPRED), and residual errors (individual weighted residual (IWRES)). When data are uninformative at the individual level, the EBE distribution will shrink towards zero (η-shrinkage, quantified as 1-SD(ηEBE)/ω), IPREDs towa
Springer US.