Pituitary Neoplasms
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. ANÁLISE DA EXPRESSÃO DOS RECEPTORES DA SOMATOSTATINA (SST1-5) E DA DOPAMINA (DR2) EM ADENOMAS HIPOFISÁRIOS / ANALYSIS OF EXPRESSION OF THE RECEPTORS OF THE SOMATOSTATIN (SST1-5) AND DOPAMINE (DR2) IN PITUITARY ADENOMAS
Pituitary tumors represent 15% of intracranial neoplasms and are usually benign. The treatment primary is surgical resection with exception for prolactinomas because dopamine agonists are very effective in the treatment these tumors. If surgery does not lead to healing, it is necessary other therapeutic strategy in a attempt to control hormone levels and tum
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/03/2012
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2. Clinical and genetic aspects of familial isolated pituitary adenomas
Pituitary adenomas represent a group of functionally diverse neoplasms with relatively high prevalence in the general population. Most occur sporadically, but inherited genetic predisposing factors are increasingly recognized. Familial isolated pituitary adenoma is a recently defined clinical entity, and is characterized by hereditary presentation of pituita
Clinics. Publicado em: 2012
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3. Temozolomide in aggressive pituitary adenomas and carcinomas
Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O6-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that are induced by temozolomide, thereby counteracting its effects.
Clinics. Publicado em: 2012
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4. Crotalus durissus terrificus venom as a source of antitumoral agents
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase patients' survival. Snake venoms are natural sources of bioactive substances with therapeutic potential. The
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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5. Identification and characterization of Crotalus durissus terrificus venom antitumoral effect and evaluation of its potential use for tumours detection / Identificação e caracterização do efeito antitumoral da peçonha de Crotalus durissus terrificus e avaliação do seu potencial uso na detecção de tumores
The neoplasms basic knowledge is increasing quickly, however, few advances have been reached in clinical therapy and diagnosis of tumours. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase the patients survival. Snake venoms are natural sources of bioactive substances with therapeutically po
Publicado em: 2007
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6. Study of mRNA expression of the receptors for vasopressin (AVPR1B), corticotropin releasing hormone (CRHR1) and GH secretagogues (GHSR-1a) in patients with ACTH-dependent Cushings syndrome: clinical-molecular correlation / Estudo da expressão do receptor da vasopressina (AVPR1B), do receptor do hormônio liberador de corticotrofina (CRHR1) e do receptor dos secretagogos de GH (GHSR-1a) em pacientes portadores de síndrome de Cushing ACTH-dependente: correlação clínico-molecular
INTRODUCTION: The differential diagnosis of ACTH-dependent Cushings syndrome (CS) is one of the major challenges in endocrinology, especially in view of the similar clinical and laboratorial behavior between some carcinoid tumors and Cushings disease (CD). Hence, dynamic tests of ACTH and cortisol release have been carried out with the aim to identify predic
Publicado em: 2006
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7. Immunocytochemistry of folliculo-stellate cells of normal and neoplastic human pituitary gland.
Five normal human pituitaries and 20 pituitary neoplasms were investigated by immunocytochemical methods. Glial fibrillary acidic protein and S100 have been shown in the anterior lobe of the pituitary. Both these markers were present in the folliculo-stellate cell. Evidence is presented for the presence of a transitional folliculo-stellate cell which is immu
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8. Clinically nonfunctioning pituitary tumors are monoclonal in origin.
Clinically nonfunctioning pituitary adenomas are benign neoplasms comprising approximately 25-30% of pituitary tumors. Little is known about the pathogenesis of pituitary neoplasia. Clonal analysis allows one to make the important distinction between a polyclonal proliferation in response to a stimulatory factor versus a monoclonal expansion of a genetically
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9. Newly diagnosed primary intracranial neoplasms in pregnant women: a population-based assessment.
The presence of a pregnancy at the time of the initial diagnosis of an intracranial neoplasm was studied using material from a population-based tumour registry. Seventeen malignant neoplasms of the brain (ICD 191), three meningiomas, three acoustic neurinomas and a pituitary adenoma associated with pregnancy were reported to the National Cancer Registry of t
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10. Immunohistochemical localization of apolipoprotein E in human glial neoplasms.
Immunocytochemical analyses revealed the presence and distribution of apolipoprotein E (apo E) in normal human brain tissue as well as in 77 human intracranial neoplasms. In normal brain tissues, the perikarya of astrocytes exhibited a strong positive reaction, whereas the Bergmann glia were stained to a moderate degree. However, no immunoreactivity was obse
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11. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.
Expression of the vascular permeability factor/vascular endothelial growth factor (VEGPF) gene was investigated in human central nervous system (CNS) neoplasms and normal brain. Adsorption of capillary permeability activity from human glioblastoma multiforme (GBM) cell conditioned medium and GBM cyst fluids by anti-VEGPF antibodies demonstrated that VEGPF is