Physiological Selectivity
Mostrando 1-12 de 96 artigos, teses e dissertações.
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1. Evaluation of the antiplasmodial and leishmanicidal potential of Myrciaria dubia (Myrtaceae) extract
Abstract INTRODUCTION: Malaria and leishmaniasis are prevalent in tropical regions, which have environmental characteristics that are highly favorable to protozoa and vectors of these diseases; the transmission of these infections in sub-tropical regions, although recognized, represents only a small fraction of cases. Plants are constantly being used in the
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-10
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2. Target-directed catalytic metallodrugs
Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets. One means of decreasing required drug concentrations is incorporation of reactive metal centers that elicit irreversible modification of targets. A common approach has been the design of artificial proteases/nucleas
Braz J Med Biol Res. Publicado em: 02/07/2013
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3. Modulação centro-contorno em campos receptivos do wulst visual
Neurons in the primary visual cortex (V1) typically show response suppression when stimulated by oriented stimuli larger than their classical receptive fields (CRF). Here, we investigate the prevalence, strength and feature selectivity of center-surround modulation in the owl visual wulst, an area that presents close hodological and physiological similaritie
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
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4. SYNTHESIS AND CHARACTERIZATION OF BINUCLEATING LIGANDS DERIVED FROM THE ISONIAZID AND THEIR DINUCLEAR COPPER(II) COMPLEXES / SÍNTESE E CARACTERIZAÇÃO DE LIGANTES BINUCLEANTES DERIVADOS DA ISONIAZIDA E SEUS COMPLEXOS BINUCLEARES DE COBRE (II)
Considering the limitations and undesirable side effects observed in cancer therapy with platinum derivatives, many efforts have been made with the aim of obtaining new drugs more effective and less toxic, able to promote the hydrolytic cleavage or oxidative DNA chain other subcellular structures critical. Until now, some copper complexes have been developed
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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5. Selectivity and behavioral response of the predator Doru luteipes to insecticides / Seletividade e resposta comportamental do predador Doru luteipes a inseticidas
Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae) é considerada a principal praga do milho no Brasil. O seu controle é realizado principalmente por inseticidas. Devido ao alto custo dos inseticidas e ao seu efeito poluidor no meio ambiente, a utilização do controle biológico pode vir a ser mais uma ferramenta de manejo junto ao controle químico. D
Publicado em: 2009
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6. TRANSPORTE E HOMEOSTASE Na+/K+ SOB CONDIÃÃES DE SODICIDADE EM FEIJÃO CAUPI / Na+ and K+ transport and homeostasis under sodicity conditions in cowpea
High soil salinity can be associated with K+ starvation enabling interactive stresses on plant nutrition that impair crop production. The transport mechanisms on the soil-root symplast-xylem boundaries are crucial to the establishment of Na+ toxicity under salt stress, especially under low K+ availability. Then, the aim of this work was the physiological cha
Publicado em: 2008
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7. Oligomerização, estruturas à baixa resolução, ligação ao DNA e ao ligante dos receptores de hormônios tireoidianos / Thyroid hormone receptor oligomerization, low resolution structures, DNA and ligand binding
The thyroid receptors (TRs) are proteins, which are involved in diverse and important physiological functions in the organisms, since they are regulators of development, cell divison and differentiation, metabolism and homeostasis. They are responsible by the regulation of specific gene transcription, through pleiotropic effects of lipophilic hormones in the
Publicado em: 2008
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8. Biodisponibilidade como parÃmetro de qualidade e sua importÃncia no registro de medicamentos / Biodisponibility as a quality pattern and its importance to the registration of medicines.
This work will discuss the bioavailability of drug, how it is changed and its importance as a quality pattern to the registration of medicines in Brazil. In this light, bioavailability will be previously conceptualized and discussed together with other topics relevant to the comprehension of this work. Bioavailability can be affected by both the patient cond
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/07/2004
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9. Modelação do processamento neuronal primário no sistema visual de mamíferos. / Modelling the primary neural processing in mammal s visual system.
Since the discovery of the receptive field properties of cortical neurons in the primary visual cortex, their organization has been studied with many methods ranging from electrophysiology and optical imaging to computational neuroscience. Few models have been capable of showing ocularity and orientation selectivity simultaneously. A large-scale computationa
Publicado em: 2001
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10. Subtraction inhibition combined with a spiking threshold accounts for cortical direction selectivity.
We have modeled simple-cell direction selectivity by a nonlinearity consisting of a subtraction inhibition followed by half-wave rectification and compared the performance of this model to that of different versions of the elaborated Reichardt detector for similar inputs and parameter settings. Not only does the subtraction model fit the experimental data mo
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11. Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity
Potassium channels are widely distributed. To serve their physiological functions, such as neuronal signaling, control of insulin release, and regulation of heart rate and blood flow, it is essential that K+ channels allow K+ but not the smaller and more abundant Na+ ions to go through. The narrowest part of the channel pore, the selectivity filter formed by
National Academy of Sciences.
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12. A neuronal network model of macaque primary visual cortex (V1): Orientation selectivity and dynamics in the input layer 4Cα
In this paper, we offer an explanation for how selectivity for orientation could be produced by a model with circuitry that is based on the anatomy of V1 cortex. It is a network model of layer 4Cα in macaque primary visual cortex (area V1). The model consists of a large number of integrate-and-fire conductance-based point neurons, both excitatory and i
The National Academy of Sciences.