Pharmacotherapeutics
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Estudo clínico comparativo de dose única pré-operatória de 50mg de rofecoxib ou diclofenado sódico no controle da dor após tratamento endodôntico
Pain management following endodontic therapy is an essential part of patient treatment. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase enzymes that abolish the effects of prostaglandins and consequently exert potent anti-inflammatory and analgesic activity. The aim of the present pilot study was to test the efficacy of prior drug admini
Publicado em: 2004
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2. Building a retrospective collection in pharmacy: a brief history of the literature with some considerations for U.S. health sciences library professionals
This paper argues that historical works in pharmacy are important tools for the clinician as well as the historian. With this as its operative premise, delineating the tripartite aspects of pharmacy as a business enterprise, a science, and a profession provides a conceptual framework for primary and secondary resource collecting. A brief history and guide to
Medical Library Association.
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3. Doxycycline control of prion protein transgene expression modulates prion disease in mice
Conversion of the cellular prion protein (PrPC) into the pathogenic isoform (PrPSc) is the fundamental event underlying transmission and pathogenesis of prion diseases. To control the expression of PrPC in transgenic (Tg) mice, we used a tetracycline controlled transactivator (tTA) driven by the PrP gene control elements and a tTA-responsive promoter linked
The National Academy of Sciences.
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4. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease
Prion diseases in humans and animals are invariably fatal. Prions are composed of a disease-causing isoform (PrPSc) of the normal host prion protein (PrPC) and replicate by stimulating the conversion of PrPC into nascent PrPSc. We report here that tricyclic derivatives of acridine and phenothiazine exhibit half-maximal inhibition of PrPSc formation at
National Academy of Sciences.
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5. Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders
G protein-coupled receptors (GPCRs) are one of the most important classes of proteins in the genome, not only because of their tremendous molecular diversity but because they are the targets of nearly 50% of current pharmacotherapeutics. The majority of these drugs affect GPCR activity by binding to a similar molecular site as the endogenous cognate ligand f
The American Society for Pharmacology and Experimental Therapeutics.