Pharmacological Screening
Mostrando 1-12 de 86 artigos, teses e dissertações.
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1. DFT, Molecular Docking, and ADME/Tox Screening Investigations of Market-Available Drugs against SARS-CoV-2
A series of drugs was investigated to determine structural, electronic and pharmacological properties, as well as the molecular affinity for the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The drugs were submitted to density functional theory calculations to optimize structures and predict binding preferences. The optimized
J. Braz. Chem. Soc.. Publicado em: 2021-08
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2. Identification of Potential Human Protein Targets for Soybean Isoflavones
Soy isoflavones have been reported as endocrine disruptors due to their ability to modulate the activity of estrogen receptors (ERs) in mammals; however, its ability to modulate other metabolic pathways is not entirely clear, which makes it necessary to identify new pharmacological targets that interact with these compounds present in soybean. In this work,
J. Braz. Chem. Soc.. Publicado em: 2021-04
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3. MÉTODO DE TRIAGEM DE MICROGININAS EM CIANOBACTÉRIAS POR LC-MS/MS
Cyanobacteria produce a wide variety of bioactive compounds, making them a highly promising group in the search for novel molecules with pharmacological and biotechnological properties. Among these, microginins attract attention for being peptides which inhibit angiotensin-converting enzyme, turning them into potential targets for hypertension and congestive
Quím. Nova. Publicado em: 2020-12
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4. Phytochemical screening and anti-implantation activity of Asparagus africanus root extract in female Sprague–Dawley rats
Abstract Asparagus africanus Lam., Asparagaceae, is used traditionally as medicinal plant for treatment of various gastrointestinal disorders and for birth related applications. This study aimed to evaluate anti-implantation potential, screening for bioactive phytochemicals and to determine its toxicity. Thirty healthy rats were distributed into five groups
Rev. bras. farmacogn.. Publicado em: 09/12/2019
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5. Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats
Resumo Campomanesia phaea (Myrtaceae), popularmente conhecida como cambuci, é uma das várias espécies de plantas que produzem frutos comestíveis amplamente utilizados na nutrição humana. Apesar de seu consumo e potencial econômico, há poucas pesquisas científicas sobre a Campomanesia, especialmente aquelas relacionadas aos seus benefícios terapêut
Braz. J. Biol.. Publicado em: 07/10/2019
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6. Screening for FMR1 expanded alleles in patients with Autism Spectrum Disorders in Manaus, Northern Brazil
Abstract: Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by dynamic mutations of a CGG repetition segment in an X chromosome’s single gene. It is considered the leading hereditary cause of both Autism Spectrum Disorders and Intellectual Disability. Some authors suggest that all individuals diagnosed with some of these latter conditions to
An. Acad. Bras. Ciênc.. Publicado em: 23/09/2019
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7. Local genotypes of dog rose from Interior Aegean region of Turkey as a unique source of pro-health compounds
ABSTRACT Rosehip, Rosa canina L. fruit, is valued for its flavor, taste, color and aroma, in accordance with its recognition as one of richest sources of pro-health compounds. Screening, preservation and propagation of the most valuable local populations of rosehip are performed for food, pharmacological, and cosmetic applications. Eleven native R. canina ge
Bragantia. Publicado em: 29/08/2019
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8. Ethnomedicinal plants used for snakebite treatments in Ethiopia: a comprehensive overview
Abstract Traditional medicine plays an important role in the daily lives of people living in rural parts of Ethiopia. Despite the fact that Ethiopia has a long history of using traditional medicinal plants as an alternative medicine source, there is no checklist compiling these plants used for snakebite treatment. This review collected and compiled available
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 05/08/2019
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9. 4D-QSAR Study of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitors
Prostate cancer is one of the most common form of cancer among men, and its incidence has been increasing progressively. Since the prostate depends on androgenic hormones to regulate its growth and development, interference with androgenic biosynthesis are important to control the disease. Thus, in this work, a 4D-quantitative structure-activity relationship
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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10. Brazilian malaria molecular targets (BraMMT): selected receptors for virtual high-throughput screening experiments
BACKGROUND Owing to increased spending on pharmaceuticals since 2010, discussions about rising costs for the development of new medical technologies have been focused on the pharmaceutical industry. Computational techniques have been developed to reduce costs associated with new drug development. Among these techniques, virtual high-throughput screening (v
Mem. Inst. Oswaldo Cruz. Publicado em: 25/02/2019
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11. 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological scr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/10/2018
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12. Anti-caries activity of selected Sudanese medicinal plants with emphasis on Terminalia laxiflora
Abstract In Sudan, some medicinal plants, such as Acacia seyal, Calotropis procera and Balanites aegyptiaca have been used to prevent or treat oral health problems. The stem and stem bark of Terminalia laxiflora Engl., Combretaceae, are used as antiseptics for mouthwash to prevent gingivitis and thrush in Africa. Methanol and 50% hydroethanolic extracts of 2
Rev. bras. farmacogn.. Publicado em: 2017-10