Pharmacokinetic
Mostrando 13-24 de 1253 artigos, teses e dissertações.
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13. Mangostanaxanthone VIIII, a new xanthone from Garcinia mangostana pericarps, α-amylase inhibitory activity, and molecular docking studies
ABSTRACT A new xanthone: mangostanaxanthone VIIII [1,3,5,6,7-pentahydroxy-2-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbut-1-enyl) xanthone] (5) and four known xanthones: mangostanaxanthones I (1) and II (2), γ-mangostin (3), and mangostanaxanthone VII (4) were separated and characterized from the acetone fraction of Garcinia mangostana L., Clusiaceae (mango
Rev. bras. farmacogn.. Publicado em: 27/05/2019
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14. What happens after an oral ingestion of haloperidol decanoate? – A case report
RESUMO O decanoato de haloperidol é um antipsicótico de primeira geração utilizado no tratamento de pacientes com esquizofrenia que requeiram tratamento antipsicótico parentérico prolongado. Casos de intoxicação oral com decanoato de haloperidol são raros, e apenas um foi reportado na literatura estrangeira. Neste artigo apresentamos o caso de inges
J. bras. psiquiatr.. Publicado em: 13/05/2019
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15. Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm�
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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16. Development and Validation of UHPLC-MS/MS for Simultaneous Determination of Scutellarin and Salicylic Acid in Rat Plasma: Application to Herb-Drug Pharmacokinetic Interaction Study
Dengzhanxixin injection (DI) product has been clinically proven to be effective for treating cardio-cerebrovascular disease. Furthermore, herb-drug interactions between the DI product and drugs that are commonly co-administered, such as aspirin, must be explored to ensure safe clinical use. A reliable ultra-performance liquid chromatography-tandem mass spect
J. Braz. Chem. Soc.. Publicado em: 2019-04
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17. Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis-infected BALB/c mice
Abstract Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side effects and resistant cases. Their pharmacokinetics remain largely unexplored. This study aimed to investigate the pharmacokinetic profile of meglumine anti
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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18. Effective vancomycin concentrations in children: a cross-sectional study
RESUMO Objetivo Analisar a efetividade microbiológica considerando a correlação farmacocinética/farmacodinâmica de vancomicina em crianças e propor uma estimativa de ajuste na dose. Métodos Trata-se de um estudo observacional, transversal, realizado em hospital pediátrico, no período de 1 ano (2016 a 2017). Foram incluídas crianças de 2 a 12 a
Einstein (São Paulo). Publicado em: 14/02/2019
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19. Sobrevida de idosos e exposição à polifarmácia no município de São Paulo: Estudo SABE
RESUMO: Introdução: O uso de polifarmácia pode ser resultante da presença concomitante de condições crônicas, atendimento por diversos médicos e automedicação. Combinada com a vulnerabilidade de idosos aos efeitos dos medicamentos devido a alterações farmacocinéticas e farmacodinâmicas, a polifarmácia torna essa população mais suscetível
Rev. bras. epidemiol.. Publicado em: 04/02/2019
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20. Determination of Mirabegron in rat plasma by UPLC–MS/MS after oral and intravenous administration
RESUMO Mirabegron é um tipo de agonista do receptor adrenérgico beta 3 que demonstra eficácia no tratamento de bexiga hiperativa. Nesta pesquisa, o método UPLC-MS/MS é desenvolvido e validado para o estudo da farmacocinética mirabegron em ratos. Um método de precipitação de proteínas é aplicado para a preparação de amostras com acetonitrilo. 397
Rev. Assoc. Med. Bras.. Publicado em: 2019-02
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21. Preparation and in vitro & in vivo evaluation of cephalexin matrix tablets
The purpose of the study is to develop cephalexin controlled-release matrix tablets by using lower proportions of release retardant polymer and to establish their in vitro & in vivo correlation. Tablets were compressed by incorporating polymers in a matrix form along with drug which prolong the drug release. Twelve formulations were prepared by mixing ethyl
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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22. Protein PEGylation for the design of biobetters: from reaction to purification processes
The covalent attachment of polyethylene glycol (PEG) to therapeutical proteins is an important route to develop biobetters for biomedical, biotech and pharmaceutical industries. PEG conjugation can shield antigenic epitopes of the protein, reduce degradation by proteolytic enzymes, enhance long-term stability and maintain or even improve pharmacokinetic and
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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23. Pharmacokinetics and safety of repirinast tablets in healthy Chinese subjects
ABSTRACT Repirinast is a new, synthetic, disodium cromoglycate-like antiallergic agent for oral administration in humans. This study evaluated the safety, tolerability and pharmacokinetics of repirinast tablets in healthy Chinese volunteers. This was a phase I, open-label, randomized, single- and multiple-dose study. Subjects were assigned to receive a singl
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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24. Design of Novel N-Myristoyltransferase Inhibitors of Leishmania donovani Using Four-Dimensional Quantitative Structure-Activity Relationship Analysis
N-Myristoylation protein is catalyzed by N-myristoyltransferase (NMT), an essential target in Leishmania donovani, the causative agent of kala-azar. Four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis was applied to a series of 77 Leishmania donovani NMT inhibitors. Then, three new compounds were proposed using QSAR models. In ad
J. Braz. Chem. Soc.. Publicado em: 2018-07