Peroxiredoxin
Mostrando 1-12 de 55 artigos, teses e dissertações.
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1. Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus
The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiova
Braz J Med Biol Res. Publicado em: 03/03/2015
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2. In silico molecular modeling and docking studies on the leishmanial tryparedoxin peroxidase
Leishmaniasis is one of the most common form of neglected parasitic disease that affects about 350 million people worldwide. Leishmanias have a trypanothione mediated hydroperoxide metabolism to eliminate endogenous or exogenous oxidative agents. Both of 2-Cys peroxiredoxin (Prx) and glutathione peroxidase type tryparedoxin peroxidase (Px) are the terminal e
Braz. arch. biol. technol.. Publicado em: 2014-04
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3. Differencial proteome of clear-cell renal cell carcinoma (ccRCC) tissues
PurposeWe attempted to detect, for the first time in a Brazilian cohort, differences in protein expression between clear-cell renal cell carcinoma (ccRCC) and their normal adjacent tissues, aiming to identify biomarkers and/or therapeutic target candidates for this disease.Material and MethodsTwenty-four ccRCC and adjacent normal tissues were collected after
Int. braz j urol.. Publicado em: 2013-01
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4. Investigação das defesas contra oxidantes provenientes do peroxissomo em Saccharomyces cerevisiae / Investigation of the defense against oxidants derived from the peroxisome in Saccharomyces cerevisiae
Defeitos peroxissomais estão associados a diversas doenças complexas. O peroxissomo é responsável pela beta-oxidação de ácidos graxos, quando é gerado peróxido de hidrogênio. A catalase A, de ocorrência peroxissomal, é frequentemente considerada a única defesa antioxidante dessa organela, porém, em diversos organismos, a ausência dessa enzima
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/09/2012
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5. Estudo da angiogenese em carcinomas salivares com e sem diferenciação mioepitelial / Angiogenesis in salivary carcinomas with and without myoepithelial differentiation
To investigate whether salivary carcinomas with and without myoepithelial differentiation could present differences regarding degree of angiogenesis, we compared tumor vascularization between adenoid cystic (31 cases) and epithelial- myoepithelial carcinomas (14) versus mucoepidermoid (37) carcinoma. The expression of peroxiredoxin I was also studied to veri
Publicado em: 2009
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6. Interações de peroxirredoxinas citossólicas da levedura Saccharomyces cerevisiae com peróxidos. Estudos cinéticos e funcionais / Saccharomyces cerevisiae cytosolic peroxiredoxin interactions with peroxides. Kinetics and functional studies
Peroxiredoxins constitute a family of cysteine-based peroxidases that are able to reduce hydrogen peroxide, organic peroxides and peroxinitrite to water, alcohol and nitrite, respectively, through the use of reducing equivalents provided by thioredoxin, thioredoxin reductase and NADPH. Peroxiredoxins are abundant enzymes (correspond to approximately 0.7% of
Publicado em: 2009
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7. Caracterização funcional e estrutural de peroxidases dependentes de tiól da bactéria fitopatogênica Xylella fastidiosa / Functional and structural characterization of thiol-dependent peroxidases from the phytopathogenic bacterium Xylella fastidiosa
A bactéria fitopatogênica Xylella fastidiosa é o agente etiológico da Clorose Variegada dos Citros (CVC), que causa perdas anuais estimadas em US$ 100 milhões no Brasil. Durante o processo infeccioso, a geração extracelular de espécies ativas de oxigênio é um dos principais mecanismos de defesa da planta contra o patógeno. Em contrapartida, para s
Publicado em: 2009
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8. Poplar Peroxiredoxin Q. A Thioredoxin-Linked Chloroplast Antioxidant Functional in Pathogen Defense1
Peroxiredoxins are ubiquitous thioredoxin- or glutaredoxin-dependent peroxidases, the function of which is to destroy peroxides. Peroxiredoxin Q, one of the four plant subtypes, is a homolog of the bacterial bacterioferritin comigratory proteins. We show here that the poplar (Populus tremula x Populus tremuloides) protein acts as a monomer with an intramolec
The American Society for Plant Biologists.
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9. Overexpression of Peroxiredoxin 6 Does Not Prevent Ethanol-Mediated Oxidative Stress and May Play a Role in Hepatic Lipid Accumulation
Oxidative stress is implicated in the etiology of many diseases, including alcoholic liver disease (ALD). Peroxiredoxin 6 is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults. Consequently, peroxiredoxin 6 was hypothesized to also protect the liver from ox
American Society for Pharmacology and Experimental Therapeutics.
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10. Hydrogen Peroxide-Forming NADH Oxidase Belonging to the Peroxiredoxin Oxidoreductase Family: Existence and Physiological Role in Bacteria
Amphibacillus xylanus and Sporolactobacillus inulinus NADH oxidases belonging to the peroxiredoxin oxidoreductase family show extremely high peroxide reductase activity for hydrogen peroxide and alkyl hydroperoxides in the presence of the small disulfide redox protein, AhpC (peroxiredoxin). In order to investigate the distribution of this enzyme system in ba
American Society for Microbiology.
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11. Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre
BioMed Central.
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12. Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product
Heme-binding protein 23 kDa (HBP23), a rat isoform of human proliferation-associated gene product (PAG), is a member of the peroxiredoxin family of peroxidases, having two conserved cysteine residues. Recent biochemical studies have shown that HBP23/PAG is an oxidative stress-induced and proliferation-coupled multifunctional protein that exhibits specific bi
The National Academy of Sciences.