Periaqueductal Gray
Mostrando 13-24 de 64 artigos, teses e dissertações.
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13. Estrous cycle and stress: influence of progesterone on the female brain
The female brain operates in a constantly changing chemical milieu caused by cyclical changes in gonadal hormones during the estrous cycle (menstrual cycle in women). Such hormones are highly lipophilic and pass readily from the plasma to the brain where they can influence neuronal function. It is becoming clear that the rapid reduction in peripheral circula
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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14. Envolvimento de receptores NK-1 e NK-3 no comportamento defensivo induzido pela estimulação elétrica da substância cinzenta periaquedutal dorsal / Involvement of NK-1 and NK-3 receptors on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray.
A substância cinzenta periaquedutal dorsal (SCPd) é considerada uma das principais estruturas do teto mesencefálico envolvida no substrato neural da aversão a estímulos proximais. GABA e 5-HT são apontados como neurotransmissores envolvidos na modulação das respostas defensivas elaboradas na SCPd. Recentemente, mecanismos neurocininérgicos também t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2011
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15. Efeito ansiolítico do ondansetron, antagonista dos receptores 5-HT3, injetado na amídala de camundongos submetidos à exposição e reexposição no labirinto em cruz elevado
Against of stimuli that are dangerous, animals manifest defense reactions that cause fear and anxiety. These stimuli activate the serotonergic system, which sends projections to structures involved in defense mechanisms such as the septum, hypothalamus, hippocampus, amygdala and periaqueductal gray modulates the behavioral changes that can be characterized a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2011
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16. Panic-like behaviors in Carioca High-and Low-conditioned Freezing rats
Panic disorder involves both recurrent unexpected panic attacks and persistent concern about having additional attacks. Electrical stimulation of the dorsal periaqueductal gray (dPAG) is an animal model of both panic attack and panic disorder, whereas contextual fear conditioning represents a model of anticipatory anxiety. Previous research indicated that an
Psychology & Neuroscience. Publicado em: 2011
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17. Estudo translacional sobre a qualidade do cuidado materno em resposta ao estresse neonatal, sua associação com ansiedade na vida adulta e investigação de potenciais mecanismos envolvidos
Introduction: In humans, there is the suggestion that an adverse early life environment is related to the development of anxiety disorders in adulthood. This association could potentially be mediated by stress responses, brain-derived neurotrophic factor (BDNF) and by neuronal nitric oxide synthase (nNOS). This study aimed at proposing an animal model for th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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18. Defense-related emotions in humans
The study of the role of serotonin in anxiety has led to the view that this neurotransmitter enhances anxiety, but inhibits panic. Validation of this hypothesis has been made using two experimental procedures that increase anxiety in human volunteers. One is classical conditioning of the skin electrical conductance response, which is assumed to represent anx
Psychology & Neuroscience. Publicado em: 2011
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19. Gabaergic mechanisms of anterior and ventromedial hypothalamic nuclei in the expression of freezing in response to a light-conditioned stimulus
The amygdala, dorsal periaqueductal gray (dPAG), and medial hypothalamus have long been recognized to comprise a neural system responsible for the generation and elaboration of unconditioned fear in the brain. This neural substrate is well known to be under tonic inhibitory control exerted by γ-aminobutyric acid (GABA) mechanisms. Some evidence also suggest
Psychology & Neuroscience. Publicado em: 2011
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20. Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors
It is well established that morphine inhibits maternal behaviors. Previous studies by our group have shown activation of the rostrolateral periaqueductal gray (rlPAG) upon inhibition-intended subcutaneous injections of morphine. In this context, we demonstrated that a single naloxone infusion into the rlPAG, following this opioid-induced inhibition, reactiva
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-09
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21. Cannabinoids, anxiety, and the periaqueductal gray
The use of Cannabis sativa by humans dates back several thousand years, for both its psychotomimetic and potential medicinal properties. As scientific research methods developed, the cannabinoids present in this herb were characterized, as well as their complex interface with the human central nervous system, provided by the activation of specific receptors.
Psychology & Neuroscience. Publicado em: 2010-06
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22. Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: influence of prior local N-methyl-D-aspartate receptor activation and aversive condition
Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation of NMDA receptors in the brain increases nitric oxide (NO) synthesis, and NO has been proposed to be a mediator of the aversive action
Psychology & Neuroscience. Publicado em: 2010-06
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23. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate
Electrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) a
Psychology & Neuroscience. Publicado em: 2010-06
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24. The hypothalamic-pituitary-adrenal axis in anxiety and panic
This review article focuses on the differential activation of the hypothalamic-pituitary-adrenal (HPA) axis in generalized anxiety and panic. The results of experimental studies that assayed adrenocorticotropic hormone, cortisol and prolactin show that real-life panic attacks as well as those induced by selective panicogenic agents, such as lactate and carbo
Psychology & Neuroscience. Publicado em: 2010-06