Peptides Inhibitors
Mostrando 13-24 de 287 artigos, teses e dissertações.
-
13. Alternative pathways for angiotensin II generation in the cardiovascular system
The classical renin-angiotensin system (RAS) consists of enzymes and peptides that regulate blood pressure and electrolyte and fluid homeostasis. Angiotensin II (Ang II) is one of the most important and extensively studied components of the RAS. The beneficial effects of angiotensin converting enzyme (ACE) inhibitors in the treatment of hypertension and hear
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09
-
14. Determination of disulfide bridges of two spider toxins: hainantoxin-III and hainantoxin-IV
Peptide toxins are usually highly bridged proteins with multipairs of intrachain disulfide bonds. Analysis of disulfide connectivity is an important facet of protein structure determination. In this paper, we successfully assigned the disulfide linkage of two novel peptide toxins, called HNTX-III and HNTX-IV, isolated from the venom of Ornithoctonus hainana
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
-
15. Estudos quantitativos multidimensionais de correlaÃÃo estrutura-atividade de inibidores peptÃdicos da HIV-1 protease / Quantitative studies of correlation structure activity of peptides inhibiters of the HIV-1 protease
A AIDS à uma doenÃa provocada por um vÃrus especÃfico, que afeta o sistema de defesa imunolÃgico. HIV-1 protease à um homodÃmero, que desempenha o papel de âtesoura molecularâ ao clivar diversas poliproteÃnas nÃo funcionais em proteÃnas menores e funcionais, de forma a produzir proteÃnas maduras. Segundo o Ãltimo informativo da The Joint United
Publicado em: 2009
-
16. The rattlesnake Crotalus durissus terrificus (Viperidae: Crotalinae) as an experimental model to study the involvement of peptidases in the survival of spermatozoids / A cascavel Crotalus durissus terrificus (Viperidae: Crotalinae) como modelo experimental para o estudo do envolvimento de peptidases na sobrevida de espermatozóides
In the rattlesnake Crotalus durissus terrificus occurs the long-term sperm storage (LTSS), in the female tract, during the interval between mating (autumn) and ovulation (spring). Peptides and peptidases are among the main components that influence the spermatic activity in mammals. The present study aimed to characterize the presence of peptidases in C. d.
Publicado em: 2007
-
17. A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity
A continuous assay using internally quenched fluorescent peptides with the general sequence Abz-peptidyl-(Dnp)P-OH (Abz = ortho-aminobenzoic acid; Dnp = 2,4-dinitrophenyl) was optimized for the measurement of angiotensin I-converting enzyme (ACE) in human plasma and rat tissues. Abz-FRK(Dnp)P-OH, which was cleaved at the Arg-Lys bond by ACE, was used for the
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-06
-
18. Caracterização do complexo proteolitico proteassoma em Strongyloides venezuelensis
Protease is an important biological process in different parasites, especially in enzymatic complex like 26S proteasome. The objective of the present work was to initiate the study of the 26S proteasome in the nematode Strongyloides venezuelensis using biochemical experiments and identifying some components of this multienzymatic complex. This nematode has b
Publicado em: 2004
-
19. Estudo quimioenzimatico da sintese de um analogo do residuo N-terminal de nikkomicinas
Nikkomycins belong to a group of nucleoside peptides antibiotics produced by streptomycets. These compounds are potent chitin synthetase inhibitors and they exhibit fungicidal, insecticidal, and acaricidal activities. Our approach began with an asymmetric reduction of ethyl benzoylacetate 37. We evaluate the biocatalytic potential of some brazilian microorga
Publicado em: 2003
-
20. Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
The kallikrein-kinin system is complex, with several bioactive peptides that are formed in many different compartments. Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. We established a
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-06
-
21. Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region
The HIV-1 gp41 envelope glycoprotein promotes fusion of the virus and cell membranes through the formation of a trimer-of-hairpins structure, in which the amino- and carboxyl-terminal regions of the gp41 ectodomain are brought together. Synthetic peptides derived from these two regions (called N and C peptides, respectively) inhibit HIV-1 entry. In cont
The National Academy of Sciences.
-
22. Inhibitors of human heart chymase based on a peptide library.
We have synthesized two sets of noncleavable peptide-inhibitor libraries to map the S and S' subsites of human heart chymase. Human heart chymase is a chymotrypsin-like enzyme that converts angiotensin I to angiotensin II. The first library consists of peptides with 3-fluorobenzylpyruvamides in the P1 position. (Amino acid residues of substrates numbered P1,
-
23. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.
The cellular mechanism underlying the generation of beta-amyloid in Alzheimer disease and its relationship to the normal metabolism of the amyloid precursor protein are unknown. In this report, we show that 3- and 4-kDa peptides derived from amyloid precursor protein are normally secreted. Epitope mapping and radiolabel sequence analysis suggest that the 4-k
-
24. A synthetic peptide corresponding to a conserved heptad repeat domain is a potent inhibitor of Sendai virus-cell fusion: an emerging similarity with functional domains of other viruses.
A series of peptides derived from three domains within the fusion protein of Sendai virus was synthesized and examined for their potential to inhibit the fusion of the virus with human red blood cells. These domains include the 'fusion peptide' and two heptad repeats, one adjacent to the fusion peptide (SV-163) and the other to the transmembrane domain (SV-4