Peptide Synthesis
Mostrando 13-24 de 1514 artigos, teses e dissertações.
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13. Effects of ovariectomy on the secretory apparatus in the right atrial cardiomyocytes of middle-aged mice
OBJECTIVE : The aim of the present study was to evaluate the effects of ovariectomy on the secretory apparatus of natriuretic peptides in right atrial cardiomyocytes. METHODS: Nine-month-old mice underwent bilateral ovariectomy or sham surgery. The blood exam of the ovariectomized mice showed results consistent with castrated females. Systolic blood press
Clinics. Publicado em: 2014-08
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14. Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide
The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood. In this study, we investigated local changes in cardiac aldosterone and its synthase in rats with ISO-induced CHF, and evaluated the effects of treatment with recombinant human brain natriuretic peptide (rhBNP). Sprague-Dawley rats were
Braz J Med Biol Res. Publicado em: 11/07/2014
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15. Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos
Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very impo
Quím. Nova. Publicado em: 2014-04
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16. Hemocidinas derivadas da hemoglobina: estruturas, propriedades e perspectivas
The increasing incidence of microbial infections, high toxicity, and high level of resistance associated with conventional antibiotics has created a need for new drugs. Antimicrobial peptides (AMPs) constitute a promising alternative and/or an important source of knowledge given their ability to inhibit the growth and/or to kill bacteria, fungi, parasites an
Quím. Nova. Publicado em: 2013
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17. Síntese e caracterização de nanoestruturas peptídicas: estudos espectroscópicos e aplicações / Synthesis and characterization of peptide nanostructures: spectroscopic studies and applications
The study had as aimed the development of nanostructured materials based on processes of molecular self-assembly of peptide compounds in order to obtain systems of great structural versatility seeking possible applications related to bionanotechnology. In this regard, peptide sequences based on linear and cyclic precursors were synthesized by solid-phase met
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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18. Expressão heteróloga de abaecina de Apis mellifera em Pichia pastoris
CHAPTER 2: Antimicrobial peptides (AMPs) are part of the immune defense that insects have developed to protection hymnoptera against pathogens. This work was done the expression of antimicrobial peptide Abaecina of Apis mellifera in fungi Pichia pastoris. A gene containing elements for cloning, purification and termination of translation was designed based o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/07/2011
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19. Síntese e caracterizaçãode nanoestruturas peptídicas funcionalizadas com polianilina / Synthesis ans caracterization of peptide nanostructures funcionalized with polyaniline
Este trabalho utilizou duas metodologias para sintetizar nanoestruturas do peptídeo L-difenilalanina (FF): em fase sólida-vapor e em fase líquida. As nanoestruturas obtidas em fase líquida foram utilizadas para estudar e quantificar (em nanogramas) o tipo de interação entre a polianilina (PANI) e os nanotubos do peptídeo L-difenilalanina (NT-FF) utili
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/05/2011
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20. Estudo da importância da cadeia lateral dos resíduos de aminoácidos da Angiotensina II, na ação biológica contra os esporozoítas da malária / Study of the importance of the side chain of amino acid residues of Angiotensin II, the biological action against malaria sporozoites
A malária é uma doença infecciosa febril aguda, cujo agente etiológico é o protozoário do gênero Plasmodium. Essa doença é transmitida por vetores, mosquitos do gênero Anopheles, destacando-se pela sua importância o A. darlingi. A Organização Mundial da Saúde (OMS) relata que 250-500 milhões de pessoas adquirem malária anualmente com, pelo me
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/02/2011
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21. Uso da FTIR na obtenção de resinas e na síntese de peptídeos em fase sólida
Despite the increase in peptide chain aggregation, which decreases the rate of coupling reactions, the synthesis and use of very highly substituted resins still remains as a controversial point in the SPPS, due to its clear economical advantages (lesser solvent consumption and higher amount of peptide per synthesis). In order to better investigate the synthe
Química Nova. Publicado em: 2011
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22. Incorporação de triciclo[6.2.1.02,7]undeca-4,9-dieno-3,6-diol como uma unidade de restrição conformacional de análogos peptídicos / Tricyclo[6.2.1.02,7] undeca-4,9- diene-3,6- diol incorporated in conformational constrained peptides analogues
O objetivo deste trabalho é a obtenção de um derivado peptídico incorporado da unidade triciclo[6.2.1.02,7]undeca-4,9-dieno-3,6-diol, obtida a partir da reação de Diels-Alder do ciclopentadieno e da pbenzoquinona, seguida de redução. A condensação em solução do tripeptídeo (Gly-L-AlaGly) com o diol produz um derivado capaz de assumir uma conform
Publicado em: 2010
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23. SYNTHESIS AND APPLICATION OF CHALCOGENIDES PEPTIDES DERIVATIVES IN ASYMMETRIC CATALYSIS / SÍNTESE E APLICAÇÃO DE CALCOGENETOS DERIVADOS DE PEPTÍDEOS EM CATÁLISE ASSIMÉTRICA
In the present work, we have developed a flexible, modular synthetic route for the preparation of new chiral chalcogen peptide derivatives containing sulfur, selenium or oxygen and evaluate their application as catalysts in enantioselective reactions. This modular approach allowed the preparation of a series of chiral compounds with a high structural diversi
Publicado em: 2010
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24. SÍNTESE E CARACTERIZAÇÃO DE COMPLEXOS DE COBRE (II) E ZINCO (II) COM DIPEPTÍDEOS DE INTERESSE BIOLÓGICO / SYTHESIS AND CHARACTERIZATION OF COPPER (II) AND ZINC (II) COMPLEXES WITH DIPEPTIDES OF BIOLOGICAL INTEREST
This work describes the synthesis and characterization of copper (II) and zinc (II) complexes, with dipeptides in solid state. The dipeptides involved were: glycyl-glycine, glycyl-valine, methionyl-methionine, methionyl-glycine and cysteinyl-glycine, whose aminoacids take part in some proteins involved in neurodegeneration processes, more specifically in Alz
Publicado em: 2010