Pentoxifylline
Mostrando 25-36 de 98 artigos, teses e dissertações.
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25. Liver lipid peroxidation and antioxidant capacity in cerulein-induced acute pancreatitis
The aim of this study was to evaluate the role of oxidative damage in pancreatitis-induced hepatic injury. Thirty-five rats were divided into five groups (each of 7 rats): control, cerulein (100 µg/kg body weight), cerulein and pentoxifylline (12 mg/kg body weight), cerulein plus L-NAME (10 mg/kg body weight) and cerulein plus L-arginine (160 mg/kg body wei
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-09
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26. Classification and hearing evolution of patients with sudden sensorineural hearing loss
The aim of this study was to analyze clinical aspects, hearing evolution and efficacy of clinical treatment of patients with sudden sensorineural hearing loss (SSNHL). This was a prospective clinical study of 136 consecutive patients with SSNHL divided into three groups after diagnostic evaluation: patients with defined etiology (DE, N = 13, 10%), concurrent
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-08
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27. Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial
PURPOSE: This study aimed to evaluate the efficacy of the systemic drugs thalidomide, dapsone, colchicine, and pentoxifylline in the treatment of severe manifestations of RAS. METHODS: An open, 4-year clinical trial was carried out for 21 consecutive patients with severe RAS. Initially, patients were given a 2-week course of prednisone to bring them to a bas
Clinics. Publicado em: 2009-03
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28. Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens
The immune response in leishmaniasis may result in a polarization of the T lymphocyte subpopulation, altering cell phenotype and resulting in immune protection or disease exacerbation. Leishmania may persist in the body either during asymptomatic infections or after treatment, which represents high risk under immunosuppression. The objective of this study wa
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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29. Effects of buflomedil and pentoxifylline on hamster skin-flap microcirculation: prediction of flap viability using orthogonal polarization spectral imaging
OBJECTIVE: This study investigated the effects of buflomedil and pentoxifylline, both of which are used in reconstructive surgery of hamster skin flap microcirculation, and evaluated the skin flap survival rate by orthogonal polarization spectral imaging. METHOD: Twenty-four adult male Syrian golden hamsters were divided into three groups: a control (C, 0.1
Clinics. Publicado em: 2009
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30. Efeitos da ventilação mecânica e pressão positiva no final da expiração sobre a microcirculação mesentérica em ratos Wistar / Effects of mechanical ventilation and positive end-expiratory pressure on mesenteric microcirculation in Wistar rats
Ventilação mecânica (MV) com pressão positiva no final da expiração (PEEP) melhora a oxigenação sanguínea e oferta de oxigênio aos tecidos no tratamento da insuficiência respiratória aguda. No entanto, a pressão intratorácica elevada pode alterar o fluxo sanguíneo no mesentério que pode contribuir para complicações gastrointestinais durante
Publicado em: 2009
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31. Importance of TNF-alpha in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
Infection of C3H/He mice with the Peruvian strain of Trypanosoma cruzi (Biodeme type I, Z2b), a macrophagotropic strain, determined severe parasitism of macrophages, necrosis of the spleen, and high host mortality. In the present study, pentoxifylline (PTX), an inhibitor of TNF-alpha was investigated on its action upon splenic necrosis, parasitemia and host
Memórias do Instituto Oswaldo Cruz. Publicado em: 31/01/2008
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32. Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury
OBJECTIVE: To evaluate the effects of pentoxifylline on hydrochloric acid-induced lung lesions in rats subjected to mechanical ventilation. METHODS: Twenty male, adult Wistar-EPM-1 rats were anesthetized and randomly grouped (n=5 animals per group) as follows: control-MV (mechanical ventilation, MV group); bilateral instillation of HCl (HCl group); bilateral
Clinics. Publicado em: 2008
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33. Insights into the regulation of TNF-a production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition
OBJECTIVE: The objective of this study was to determine the effect of nonspecific phosphodiesterase inhibition on transcription factor activation and tumor necrosis factor-alpha (TNF-a) production in lipopolysaccharide (LPS)-stimulated human mononuclear cells. INTRODUCTION: The production of TNF-a following LPS stimulation is one of the key steps in bacteria
Clinics. Publicado em: 2008
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34. Effects of pentoxifylline treatment before freezing on motility, viability and acrosome status of poor quality human spermatozoa cryopreserved by the liquid nitrogen vapor method
The objective of the present study was to investigate the effects of the direct addition of pentoxifylline (PF) to the ejaculates of men with poor sperm quality before freezing on post-thaw sperm motility, viability, acrosome integrity, and agonist-induced acrosome reaction. Semen specimens from 16 infertile men with impaired sperm count and motility (oligoa
Brazilian Journal of Medical and Biological Research. Publicado em: 04/06/2007
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35. Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy
Type II reaction in leprosy, or erythema nodosum leprosum (ENL), is often characterized by severe clinical symptoms together with nerve function impairment leading to permanent disabilities. Thalidomide has been shown to be a highly effective drug for the treatment of ENL. It is, however, contraindicated for women of childbearing age due to its teratogenicit
Brazilian Journal of Medical and Biological Research. Publicado em: 13/02/2007
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36. In vitro effects of pentoxifylline on human fibroblasts derived from post-burn hypertrophic scars and from normal skin / Estudo in vitro da ação de pentoxifilina em fibroblastos oriundos de cicatrizes hipertróficas pós-queimadura e de pele não-cicatricial
Pentoxifilina (PTF), um derivado da metilxantina, tem ação terapêutica como agente antifibrótico. In vitro, a PTF causa inibição na produção de colágeno, glicosaminoglicanos e fibronectina, bem como promove acentuada redução na proliferação dos próprios fibroblastos de quelóides. A PTF na concentração de 1.000 g/mL foi seletiva no controle d
Publicado em: 2007