Penalty Techniques
Mostrando 13-13 de 13 artigos, teses e dissertações.
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13. An enzymatic molten globule: Efficient coupling of folding and catalysis
A highly active, monomeric chorismate mutase, obtained by topological redesign of a dimeric helical bundle enzyme from Methanococcus jannaschii, was investigated by NMR and various other biochemical techniques, including H/D exchange. Although structural disorder is generally considered to be incompatible with efficient catalysis, the monomer, unlike its nat
National Academy of Sciences.