Pedf
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Hipóxia intermitente crônica aumenta a expressão gênica, mas não proteica, de pigment epithelium-derived factor no córtex temporal de ratos
Objetivo: A síndrome da apneia obstrutiva do sono caracteriza-se principalmente por episódios de hipóxia intermitente (HI) durante o sono e associa-se a diversas complicações. A exposição à HI é o mais usado modelo animal de apneia do sono, e protocolos de curta duração causam diversos prejuízos cognitivos e neuronais. Pigment epithelium-derived
J. bras. pneumol.. Publicado em: 2015-02
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2. Análise dos mecanismos de neuroplasticidade na porção lombar da medula espinal do rato submetida à lesão isquêmica fototrombótica e tratada pela injeção local de PEDF / Analysis of neuroplasticity mechanisms in lumbar levels of the rat spinal cord submitted to photothrombotic ischemia and treated with local injection of PEDF
O fator derivado do epitélio pigmentado (PEDF) é um fator neurotrófico que possui um grande potencial trófico nos neurônios motores da medula espinal, bem como é capaz de modular o microambiente da lesão. Desta forma, analisamos a capacidade do tratamento com PEDF em promover a neuroplasticidade da medula espinal após lesão isquêmica. Ratos Wistar
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
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3. Efeitos das células de schwann cultivadas e tratadas com o pedf no trofismo de neurônios medulares cultivados e na recuperação motora de ratos submetidos ao trauma contuso da medula espinal pelo impactor / Effect of the cells of Schwann cultivated and treated with the PEDF in the trophism to spinal cord neurons cultivated and in the motor recovery of rats submitted to the trauma contused of the spinal cords for the Impactor
The present study aimed the assessment of the trophic and regenerative potential of the Schwann cells (SC) and of the neurotrophic factor PEDF on the spinal cord neurons by means of cultures of those cells in vitro as well as in an experimental model of a contused spinal cord lesion in vivo. SC were cultivated from sciatic nerves fragments of young adult rat
Publicado em: 2008
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4. Angiogênese e doenças da retina
Angiogênese é o processo de formação de vasos sangüíneos a partir de vasos preexistentes, que ocorre em condições fisiológicas e patológicas. É fenômeno complexo no qual participam inúmeras moléculas que estimulam e inibem a formação dos neovasos. O aumento da permeabilidade vascular e a neovascularização sub-retiniana são as causas da per
Arquivos Brasileiros de Oftalmologia. Publicado em: 2007-06
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5. Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor
Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serpin superfamily, is the most potent inhibitor of angiogenesis in the mammalian ocular compartment. It also has neurotrophic activity, both in the retina and in the central nervous system, and is highly up-regulated in young versus senescent fibroblasts. To provide a structural ba
The National Academy of Sciences.
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6. Pigment Epithelium-derived Factor Maintains Retinal Pigment Epithelium Function by Inhibiting Vascular Endothelial Growth Factor-R2 Signaling through γ-Secretase*
Wet age-related macular degeneration (AMD) attacks the integrity of the retinal pigment epithelium (RPE) barrier system. The pathogenic process was hypothesized to be mediated by vascular endothelial growth factor (VEGF) and antagonized by pigment epithelium-derived factor (PEDF). To dissect these functional interactions, monolayer cultures of RPE cells were
American Society for Biochemistry and Molecular Biology.
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7. Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site
Vascular permeability plays a key role in a wide array of life-threatening and sight-threatening diseases. Vascular endothelial growth factor can increase vascular permeability. Using a model system for nonproliferative diabetic retinopathy, we found that pigment epithelium-derived factor (PEDF) effectively abated vascular endothelial growth factor-induced v
National Academy of Sciences.
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8. Nuclear Receptor Co-repressor Is Required to Maintain Proliferation of Normal Intestinal Epithelial Cells in Culture and Down-modulates the Expression of Pigment Epithelium-derived Factor*
Stem cells of the gut epithelium constantly produce precursors that progressively undergo a succession of molecular changes resulting in growth arrest and commitment to a specific differentiation program. Few transcriptional repressors have been identified that maintain the normal intestinal epithelial cell (IEC) proliferation state. Herein, we show that the
American Society for Biochemistry and Molecular Biology.
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9. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.
Cultured pigment epithelial cells of the fetal human retina secrete a protein, pigment epithelium-derived factor (PEDF), that induces a neuronal phenotype in cultured human retinoblastoma cells. Morphological changes include the induction of an extensive neurite meshwork and the establishment of corona-like cellular aggregates surrounding a central lumen. Th
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10. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
Aberrant blood vessel growth in the retina that underlies the pathology of proliferative diabetic retinopathy and retinopathy of prematurity is the result of the ischemia-driven disruption of the normally antiangiogenic environment of the retina. In this study, we show that a potent inhibitor of angiogenesis found naturally in the normal eye, pigment ep
The National Academy of Sciences.
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11. Autologous transplantation of genetically modified iris pigment epithelial cells: A promising concept for the treatment of age-related macular degeneration and other disorders of the eye
Age-related macular degeneration (ARMD) is the leading cause for visual impairment and blindness in the elder population. Laser photocoagulation, photodynamic therapy and excision of neovascular membranes have met with limited success. Submacular transplantation of autologous iris pigment epithelial (IPE) cells has been proposed to replace the damaged retina
The National Academy of Sciences.
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12. PEDF: Raising both hopes and questions in controlling angiogenesis
The National Academy of Sciences.