Particulate Adjuvant
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Enhancement of Mucosal Immunization with Virus-Like Particles of Simian Immunodeficiency Virus
Cholera toxin (CT) is the most potent known mucosal adjuvant, but its toxicity precludes its use in humans. Here, in an attempt to develop safe and effective mucosal adjuvants, we compared immune responses to simian immunodeficiency virus (SIV) virus-like particles (VLPs) after intranasal coimmunization with RANTES, CpG oligodeoxynucleotides (ODN), or CT. An
American Society for Microbiology.
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14. Influence of Intravenous Anesthesia on Mucosal and Systemic Antibody Responses to Nasal Vaccines
Inhalation of antigens may stimulate the immune system by way of the upper as well as the lower airways. We have shown that at least 1,000 times more live pneumococci were recovered from pulmonary tissue after being presented as drops of a liquid suspension onto the nares of anesthetized mice compared to the number of bacteria recovered from animals that wer
American Society for Microbiology.
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15. Immunogenicity of Ribonucleic Acid Preparations Obtained from Salmonella typhimurium1
Mice immunized with purified whole-cell ribonucleic acid (RNA), RNA from the bacterial “particulate” fraction, and ribosome-associated RNA obtained from Salmonella typhimurium were found to be resistant to subsequent challenge infection with virulent salmonellae. Chemically, the immunogenic nucleic acid fractions contained from 1 to 3% “contaminant”