Parp 1
Mostrando 13-24 de 117 artigos, teses e dissertações.
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13. Avaliação da progressão tumoral do câncer de laringe associada à infecção pelo Papilomavírus Humano (HPV) / Evaluation of tumor progression in laryngeal carcinoma associated with human Papilomavirus (HPV) infection.
Para que ocorra a transição do epitélio normal de laringe para carcinoma escamoso é necessário um processo de múltiplas etapas tal como exposição prolongada ao fumo e álcool e uma possível associação à infecção pelo HPV. Vários tipos de marcadores moleculares vêm sendo estudados na carcinogênese da laringe, entre eles proteínas associadas
Publicado em: 2009
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14. Associação entre polimorfismos em enzimas de reparo de DNA e ocorrência de meningite bacteriana.
Apesar dos avanços no desenvolvimento de vacinas e terapias, a meningite bacteriana (MB) continua sendo uma das principais causas de morte e seqüelas neurológicas causadas por uma doença infecciosa. Como parte da resposta inflamatória ao patógeno invasor, fatores como espécies reativas de oxigênio (ROS) são geradas, podendo causar danos no DNA e ati
Publicado em: 2008
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15. The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity
Recent work has demonstrated that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron-transport chain triggers several pathways of injury [(protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product formation (AGE)] involved in the pathogenesis of diabetic complications by inhibiting glyceraldehy
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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16. Associação gravidez e cancer : comprometimento da atividade placentaria : estudo em ratas prenhes portadoras do tumor de Walker 256
A placenta provê todas as necessidades para o crescimento e desenvolvimento fetal. Na presença de neoplasia é difícil predizer qual será a duração, evolução e termo da gravidez. O crescimento tumoral é prejudicial à mãe e á unidade materno fetal. O substrato energético fundamental usado pelo feto é a glicose proveniente da placenta, já que o
Publicado em: 2003
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17. PARP-1 Deficiency Increases the Severity of Disease in a Mouse Model of Multiple Sclerosis*
Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood. Therefore, we studied experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis in mice with a targeted deletion of PARP-1. We i
American Society for Biochemistry and Molecular Biology.
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18. Transcription regulation of TNF-α-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells
Poly(ADP-ribose) polymerase-1 (PARP-1) has been involved in endothelial cell dysfunction associated with various pathophysiological conditions. The intrinsic mechanism of PARP-1-mediated endothelial cell dysfunction could be related to PARP-1 overactivation, NAD+ consumption and ATP depletion. An alternative way could involve transcription regulation. By usi
Oxford University Press.
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19. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
The DNA damage-dependent poly(ADP-ribose) polymerases, PARP-1 and PARP-2, homo- and heterodimerize and are both involved in the base excision repair (BER) pathway. Here, we report that mice carrying a targeted disruption of the PARP-2 gene are sensitive to ionizing radiation. Following alkylating agent treatment, parp-2–/–-derived mouse embryonic fibrobl
Oxford University Press.
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20. Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines
We reported that PARP-1 exhibits differential roles in expression of inflammatory factors. Here, we show that PARP-1 deletion was associated with a significant reduction in inflammatory cell recruitment to mouse airways upon intratracheal administration of LPS. However, PARP-1 deletion exerted little effect in response to TNF exposure. LPS induced massive ne
The Society for Leukocyte Biology.
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21. Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells
PARP-1 [poly(ADP-ribose) polymerase-1) is a nuclear enzyme that is involved in several cellular functions, including DNA repair, DNA transcription, carcinogenesis and apoptosis. The activity directed by the PARP-1 gene promoter is mainly dictated through its recognition by the transcription factors Sp1 and Sp3 (where Sp is specificity protein). In the presen
Portland Press Ltd..
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22. Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
PARP-1-deficient mice display a severe defect in the base excision repair pathway leading to radiosensitivity and genomic instability. They are protected against necrosis induced by massive oxidative stress in various inflammatory processes. Mice lacking p53 are highly predisposed to malignancy resulting from defective cell cycle checkpoints, resistance to D
Oxford University Press.
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23. Chromosomal aberrations in PARP−/− mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic agents, implicating PARP in the maintenance of genomic stability. Flow cytometric analysis now has revealed an unstable tetraploid population in immortalized fibrobla
The National Academy of Sciences.
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24. Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice
Poly(ADP-ribosyl)ation is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is known to be involved in various cellular processes, such as DNA repair, genomic stability, transcription, and cell death. During apoptosis, PARP-1 is cleaved by caspases to generate 89-kDa and 24-kDa fragments, a hallma
American Society for Clinical Investigation.