Pancreatic Islet Transplantation
Mostrando 1-12 de 39 artigos, teses e dissertações.
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1. Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy
Diabetes mellitus represents a serious public health problem owing to its global prevalence in the last decade. The causes of this metabolic disease include dysfunction and/or insufficient number of β cells. Existing diabetes mellitus treatments do not reverse or control the disease. Therefore, β-cell mass restoration might be a promising treatment. Severa
Braz J Med Biol Res. Publicado em: 10/07/2015
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2. Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory
Type 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high morbidity and mortality rates in young adults of productive age. Intensive insulin therapy has been able to reduce the likelihood of the development of chronic diabetes complications. However, this treatment is still associated with an increased incidence of hypoglycem
Arch. Endocrinol. Metab.. Publicado em: 2015-04
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3. A suplementação com glutationa-etil-éster durante o isolamento de ilhotas pancreáticas em roedores melhora a viabilidade celular e os resultados do transplante de ilhotas / Glutathione ethyl ester supplementationduring pancreatic islet isolation improves viability and transplant outcomes in a murine marginal islet mass model
As complicações relacionadas ao diabetes mellitus estão intimamente ligadas à hiperglicemia. Os pacientes que evoluem com grande instabilidade metabólica e progressão das complicações microvasculares apesar do tratamento intensivo com insulina são candidatos ao transplante de pâncreas. Neste contexto, o transplante de ilhotas pancreáticas surge co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/09/2012
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4. Imunoproteção de ilhotas pancreáticas microencapsuladas em biomateriais inovadores e seu potencial terapêutico no diabetes mellitus tipo 1 / Immunoprotection of pancreatic islets microencapsulated in inovative biomaterials and its therapeutic potential in type 1 Diabetes Mellitus
Transplantation of microencapsulated islets represents an attractive therapeutical approach to treat type 1 Diabetes Mellitus, accounting for an improved glycemic control and the abolishment of immunosuppressive therapies. However, maintenance of long-term β-cell viability remains a major problem. During islet isolation, the loss of extracellular matrix
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/05/2012
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5. Obtention of human pancreatic islets for transplantation through an increase in cell mass and an immunoisolation with biocompatible microcapsules / Ilhotas pancreáticas humanas viáveis para o transplante através do aumento da massa de células e do imunoisolamento com microcápsulas biocompatíveis
Islet transplantation has been proposed as a promising therapeutic strategy for the cure of type 1 diabetes mellitus (DM), however, its application to all diabetic patients is still not possible due to the limited source of islets or β cells and to the need of an immunosuppressive treatment of the recipient to avoid graft rejection. The use of immunosup
Publicado em: 2009
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6. Identification of differentialy express genes during the differentiation of stem cells and characterization of mesenchymal progenitor cells / Identificação de genes diferencialmente expressos durante diferenciação de células-tronco e caracterização de células progenitoras mesenquimais
Diabetes mellitus (DM) defines a number of pathologies caused by the lack or deficient action of the insulin hormone. DM1 is caused by an auto-immune attack to insulin secreting β-pancreatic cells, while DM2 is related to ageing and obesity. Pancreas and islet allo-transplantation constitute therapeutic alternatives, but severe organ shortage and the ab
Publicado em: 2008
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7. Avaliação do estresse oxidativo em ilhotas pancreáticas humanas e em cultura de células INS-1E / Evaluation of oxidative stress in human pancreatic islets and INS-1E cells culture
Human pancreatic islet transplantation is considered a promising strategy to cure the cure Diabetes Mellitus type I. However, transplantation efficiency is dramatically affected by sub-optimum islet recovery in the isolation/purification procedure and islet viability after transplantation. Isolated pancreatic islets are obtained through collagenase perfusion
Publicado em: 2007
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8. Secondary prevention of type 1 diabetes mellitus: stopping immune destruction and promoting ß-cell regeneration
Type 1 diabetes mellitus results from a cell-mediated autoimmune attack against pancreatic ß-cells. Traditional treatments involve numerous daily insulin dosages/injections and rigorous glucose control. Many efforts toward the identification of ß-cell precursors have been made not only with the aim of understanding the physiology of islet regeneration, but
Brazilian Journal of Medical and Biological Research. Publicado em: 21/08/2006
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9. Cloning and characterization of glucose-regulated genes in human pancreatic islets / "Clonagem e caracterização de genes regulados por glicose em ilhotas pancreáticas humanas"
Type 1 Diabetes mellitus (T1DM) is caused by autoimmune destruction of the insulin-producing pancreatic islet b-cells. Treatment is generally approached by daily subcutaneous injections of exogenous insulin. Nowadays, pancreatic islet transplantation is considered as an effective alternative treatment to insulin therapy. However, in order to reach insulin-in
Publicado em: 2002
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10. Microencapsulation and tissue engineering as an alternative treatment of diabetes
In the 70's, pancreatic islet transplantation arose as an attractive alternative to restore normoglycemia; however, the scarcity of donors and difficulties with allotransplants, even under immunosuppressive treatment, greatly hampered the use of this alternative. Several materials and devices have been developed to circumvent the problem of islet rejection b
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-06
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11. Pancreatic Islet Transplantation
Islet transplantation offers hope to many patients with diabetes, who envision a life free of glucose checks and insulin injections. What are the barriers to its widespread implementation?
Public Library of Science.
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12. Tolerance and pancreatic islet transplantation.
Islet transplantation holds renewed promise as a cure for type I diabetes mellitus. Results of recent clinical trials have shown remarkable success, and have reignited universal optimism for this procedure. In spite of this success, the need for life-long immunosuppression of the recipient still limits islet transplantation to patients with poorly controlled