Pancreatic Elastase
Mostrando 1-12 de 68 artigos, teses e dissertações.
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1. Pancreatic endosonographic findings and clinical correlation in Crohn's disease
OBJECTIVES: We aimed to evaluate the incidence of pancreatic alterations in Crohn's disease using endoscopic ultrasound (EUS) and to correlate the number of alterations with current clinical data. METHODS: Patients diagnosed with Crohn's disease (n=51) were examined using EUS, and 11 variables were analyzed. A control group consisted of patients with no hi
Clinics. Publicado em: 30/05/2019
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2. Avaliação da insuficiência pancreática pelo teste elastase-1 fecal em pacientes pediátricos com fibrose cística portadores da mutação DF508
Introdução e objetivo: Elastase-1 fecal (EL-1) é um teste não invasivo que serve para avaliar a função pancreática exócrina. Neste estudo, buscou-se avaliar e quantificar a concentração da EL-1 fecal em pacientes com Fibrose Cística (FC), portadores da mutação ΔF508, e padronizar o teste Elastase monoclonal para a população estudada. Métodos
Publicado em: 2010
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3. Influência do diabetes mellitus na evolução do enfisema pulmonar induzido por elastase em ratos / Influence of diabetes mellitus on the course of pulmonary emphysema induced by elastase in rats
The present study was undertaken to investigate the role of insulin in the development of acute and chronic inflammatory responses in porcine pancreatic elastase (PPE)-induced pulmonary emphysema. Diabetic male Wistar rats (alloxan, 42 mg/kg, i.v., 10 days) and control rats were instilled with physiological saline solution containing PPE (0.25 IU/0.2 mL, rig
Publicado em: 2008
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4. Avaliação do pâncreas através da ecoendoscopia em pacientes portadores de Doença de Crohn / Pancreas evaluation using the endoscopic ultrasound in Crohns disease
INTRODUÇÃO: O comprometimento pancreático em pacientes com Doença de Crohn (DC) é objeto de poucos estudos, porém as poucas séries sobre o assunto indicam um acometimento de uma parcela significativa dos pacientes, variando de 1,2% a 58%. O ultra-som endoscópico (EUS) apresenta a vantagem de apresentar uma sensibilidade muito maior que o ultra-som ab
Publicado em: 2008
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5. Analise dos alelos S e Z da alfa 1 antitripsina em uma amostra de pacientes fibrocisticos
Cystic fibrosis is a genetic disorder that during its course presents mainly pulmonary and pancreatic manifestations. Its genotype-phenotype correlation has motivated many arduous studies. The only correlation so far encountered is with pancreatic insufficiency. It has also been noted that the course of the disease as well as the severity of its pulmonary ma
Publicado em: 2002
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6. Role of alpha-macroglobulin-elastase complexes in the pathogenesis of elastase-induced emphysema in hamsters.
Radiolabeled, enzymatically active or chloromethyl ketone-inactivated porcine pancreatic elastase was endotracheally instilled into hamsters. Gel filtration of the bronchopulmonary lavage fluid revealed two major radioactive fractions: one, eluting at 780,000 daltons, corresponding to an alpha-macroglobulin-pancreatic elastase complex, and another, at 68,000
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7. Primary structure of human neutrophil elastase.
The complete amino acid sequence of human neutrophil elastase has been determined. The protein consists of 218 amino acid residues, contains two asparagine-linked carbohydrate side chains, and is joined together by four disulfide bonds. Comparison of the sequence to other serine proteinases indicates only moderate homology with porcine pancreatic elastase (4
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8. The cell-specific elastase I enhancer comprises two domains.
Two separate domains within the 134-base-pair rat elastase I enhancer and a third domain at the enhancer-promoter boundary are required for selective expression in pancreatic acinar cells. The domains were detected by a series of 10-base-pair substitution mutations across the elastase I gene regulatory region from positions -200 to -61. The effect of each mu
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9. Oxygen derived free radicals in patients with chronic pancreatic and other digestive diseases.
To ascertain modifications in the activation products derived from oxygen free radicals in patients with chronic pancreatic and extra-pancreatic diseases, lipid peroxide activity was measured in the sera of 40 control subjects, 28 patients with pancreatic cancer, 49 with chronic pancreatitis, and 53 with extra-pancreatic diseases. In 142 of the subjects, ela
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10. Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.
The development of pancreatic cancer in transgenic mice expressing the simian virus 40 tumor antigen placed under controlling regions of the elastase I gene is characterized by the sequential appearance of tetraploid and then multiple aneuploid cell populations. Pancreatic tissues from such transgenic mice were studied between 8 and 32 days of age. Virtually
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11. Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents.
The effects of neutrophil elastase on endothelial prostacyclin (PGI2) production, nucleotide release, and responsiveness to vasoactive agents were compared with the effects of cathepsin G (the other major neutral protease of neutrophils), pancreatic elastase, trypsin, chymotrypsin, and thrombin. PGI2 production by pig aortic endothelial cells cultured on mic
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12. Elastolytic activity of alveolar macrophages in chronic bronchitis: comparison of current and former smokers.
We have compared the macrophage elastolytic activity of a group of current and former smokers with irreversible airflow obstruction. Elastolytic activity was determined in an initial bronchoalveolar lavage cell population and in alveolar macrophages cultured for three days, to investigate whether enhanced macrophage elastolytic activity alone is a determinin