Panc 3
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression
Pancreatic cancer is well known to be the most deadly malignancy with the worst survival rate of all cancers. High temperature requirement factor A1 (HtrA1) plays an important role in cancer cell proliferation, migration, apoptosis, and differentiation. This study aimed to explore the function of HtrA1 in pancreatic cancer cell growth and its underlying mech
Braz J Med Biol Res. Publicado em: 23/11/2018
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2. ESCORE PANC 3 NA PREDIÇÃO DA SEVERIDADE DE PANCREATITE AGUDA
Racional: Cerca de 20% dos casos de pancreatite aguda evoluem de forma severa, acompanhados de alta mortalidade. Diversos estudos têm sugerido métodos para identificar pacientes que evoluirão com maior gravidade. Entretanto, a maioria apresenta problemas em sua utilização na prática diária. Objetivo: Avaliar a eficácia do escore PANC 3 na prediç
ABCD, arq. bras. cir. dig.. Publicado em: 2016-03
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3. Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines
Pancreatic cancer is the fourth leading cause of cancer death. Gemcitabine is widely used as a chemotherapeutic agent for the treatment of pancreatic cancer, but the prognosis is still poor. Berberine, an isoquinoline alkaloid extracted from a variety of natural herbs, possesses a variety of pharmacological properties including anticancer effects. In this st
Braz J Med Biol Res. Publicado em: 12/12/2014
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4. A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay
Current therapy for pancreatic cancer is multimodal, involving surgery and chemotherapy. However, development of pancreatic cancer therapies requires a thorough evaluation of drug efficacy in vitro before animal testing and subsequent clinical trials. Compared to two-dimensional culture of cell monolayer, three-dimensional (3-D) models more closely mimic nat
Braz J Med Biol Res. Publicado em: 22/07/2013
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5. Prognóstico dos casos de pancreatite aguda pelo escore de PANC 3
RACIONAL: A pancreatite aguda é doença de grande importância na prática clínica, definida como inflamação do pâncreas podendo levar ao envolvimento de tecidos locais ou acometimento de outros órgãos de forma sistêmica, necessitando nesses casos de cuidados em terapia intensiva. OBJETIVO: Analisar o sistema simplificado de estratificação de PANC
ABCD, arq. bras. cir. dig.. Publicado em: 2013-06
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6. Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates
Development of the endocrine pancreas includes a series of early events wherein precursor cells cluster, that is migrate to form cell aggregates, which subsequently differentiate into islets of Langerhans. We show that PANC-1 cells, a human pancreatic cell line, differentiates into hormone-producing islet-like cell aggregates after exposure to a defined
National Academy of Sciences.
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7. Isolation and characterization of Escherichia coli pantothenate permease (panF) mutants.
Mutants of Escherichia coli K-12 defective in the pantothenate permease (panF) were isolated and characterized. The panF mutation resulted in the complete loss of pantothenate uptake and of the ability to use extracellular vitamin for growth. The growth phenotypes of panF panD, panF panB, and panF panC double mutants showed that the cytoplasmic membrane was
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8. Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.
Previous work showed that cultured human pancreatic cancer cells overexpress the epidermal growth factor (EGF) receptor. In the present study, we sought to determine whether some of these cell lines produce transforming growth factor alpha (TGF-alpha). Utilizing a radiolabeled TGF-alpha cDNA in hybridization experiments, we determined that ASPC-1, T3M4, PANC
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9. Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer.
Recently, the gene for the epidermal growth factor (EGF) receptor has been mapped to chromosome 7p, the short arm of chromosome 7 [Shimizu, N., Kondo, I., Gamou, M. A., Behzadian, A. & Shimizu, Y. (1984) Somatic Cell Mol. Genet. 10, 45-53]. Utilizing EGF binding in saturation studies, karyology, and cDNA hybridization experiments, we have sought to determine
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10. Interleukin-32 Expression in the Pancreas
Interleukin (IL)-32 is a recently described proinflammatory cytokine characterized by the induction of nuclear factor (NF)-κB activation. We studied IL-32 expression in human pancreatic tissue and pancreatic cancer cell lines. Tissue samples were obtained surgically. IL-32 expression was evaluated by standard immunohistochemical procedures. IL-32 mRNA expre
American Society for Biochemistry and Molecular Biology.
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11. MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting
CYP3A4 metabolizes many drugs on the market. Although transcriptional regulation of CYP3A4 is known to be tightly controlled by some nuclear receptors (NR) including vitamin D receptor (VDR/NR1I1), posttranscriptional regulation of CYP3A4 remains elusive. In this study, we show that noncoding microRNAs (miRNAs) may control posttranscriptional and transcripti
The American Society for Pharmacology and Experimental Therapeutics.
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12. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that specifically disrupt this interaction might have desirable chemotherapeutic properties. We used a subtractive forward two-hybrid approach to identify small molecule compounds that block the interactio
National Academy of Sciences.